scholarly journals Positive Correlation between Estradiol and Vascular Endothelial Growth Factor but not Fibroblast Growth Factor-2 in Normal Human Breast Tissue In vivo

2005 ◽  
Vol 11 (22) ◽  
pp. 8036-8041 ◽  
Author(s):  
Charlotta Dabrosin
Keyword(s):  
Growth Factor ◽  
Breast Tissue ◽  
Fibroblast Growth Factor 2 ◽  
Vascular Endothelial ◽  
Human Breast ◽  
Human Breast Tissue ◽  
Normal Human Breast ◽  
Normal Human ◽  
Endothelial Growth Factor

scholarly journals Variability of Vascular Endothelial Growth Factor in Normal Human Breast Tissue in Vivo during the Menstrual Cycle

2003 ◽  
Vol 88 (6) ◽  
pp. 2695-2698 ◽  
Author(s):  
Charlotta Dabrosin
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Breast Tissue ◽  
Vascular Endothelial ◽  
Human Breast ◽  
Human Breast Tissue ◽  
Normal Human Breast ◽  
Normal Human ◽  
Endothelial Growth Factor

Exposure to sex steroids increases the risk of breast cancer, but the mechanisms are poorly understood. Angiogenesis is crucial in tumor development and progression. Very little is known about the regulation of angiogenesis in the normal breast. Vascular endothelial growth factor (VEGF) has a key stimulatory role in angiogenesis. Interferon-inducible protein 10 (IP-10) is a potent inhibitor of angiogenesis in vivo. These factors function in autocrine/paracrine pathways; therefore, direct measurements in the target tissue are needed. I measured VEGF and IP-10 in normal human breast tissue in situ in healthy women, using microdialysis, in the follicular and luteal phase of the menstrual cycle. In breast tissue, VEGF levels increased in the luteal phase, compared with the follicular phase (17.8 ± 4 pg/ml to 34 ± 9 pg/ml, P < 0.05). Plasma VEGF did not show a cyclic variation (10.6 ± 2.8 pg/ml vs. 14.6 ± 3.5 pg/liter, P = 0.3). IP-10 levels did not vary during the menstrual cycle either in breast tissue (65 ± 17 pg/ml vs. 75 ± 21 pg/ml, P = 0.6) or in plasma (64 ± 7 pg/ml vs. 81 ± 10 pg/ml, P = 0.06). The data suggests that, in the luteal phase, VEGF and IP-10, in the normal human breast, exhibit a proangiogenic profile. This may be one mechanism by which sex steroids contribute to breast cancer development.

scholarly journals Tamoxifen and Flaxseed Alter Angiogenesis Regulators in Normal Human Breast Tissue In Vivo

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e25720 ◽  
Author(s):  
Ulrika W. Nilsson Åberg ◽  
Niina Saarinen ◽  
Annelie Abrahamsson ◽  
Tarja Nurmi ◽  
Sofia Engblom ◽  
...  
Keyword(s):  
Breast Tissue ◽  
Human Breast ◽  
Human Breast Tissue ◽  
Normal Human Breast ◽  
Normal Human

scholarly journals Estradiol, Tamoxifen, and Flaxseed Alter IL-1β and IL-1Ra Levels in Normal Human Breast Tissue in Vivo

2012 ◽  
Vol 97 (11) ◽  
pp. E2044-E2054 ◽  
Author(s):  
Annelie Abrahamsson ◽  
Vivian Morad ◽  
Niina M. Saarinen ◽  
Charlotta Dabrosin
Keyword(s):  
Breast Tissue ◽  
Human Breast ◽  
Human Breast Tissue ◽  
Normal Human Breast ◽  
Normal Human
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