scholarly journals Antitumor Effects of Systemically Delivered Adenovirus Harboring Trans-Splicing Ribozyme in Intrahepatic Colon Cancer Mouse Model

2008 ◽  
Vol 14 (1) ◽  
pp. 281-290 ◽  
Author(s):  
J.-S. Jeong ◽  
S.-W. Lee ◽  
S.-H. Hong ◽  
Y.-J. Lee ◽  
H.-I. Jung ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mouse Model ◽  
Antitumor Effects ◽  
Trans Splicing

scholarly journals Evaluation of the antitumor effects of PP242 in a colon cancer xenograft mouse model using comprehensive metabolomics and lipidomics

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Md Mamunur Rashid ◽  
Hyunbeom Lee ◽  
Byung Hwa Jung
Keyword(s):  
Colon Cancer ◽  
Mouse Model ◽  
High Performance ◽  
Tca Cycle ◽  
Treated Group ◽  
Metabolic Changes ◽  
Antitumor Effects ◽  
Xenograft Mouse Model ◽  
Metabolic Mechanism ◽  
Comprehensive Metabolomics

Abstract PP242, an inhibitor of mechanistic target of rapamycin (mTOR), displays potent anticancer effects against various cancer types. However, the underlying metabolic mechanism associated with the PP242 effects is not clearly understood. In this study, comprehensive metabolomics and lipidomics investigations were performed using ultra-high-performance chromatography-Orbitrap-mass spectrometry (UHPLC-Orbitrap-MS) in plasma and tumor tissue to reveal the metabolic mechanism of PP242 in an LS174T cell-induced colon cancer xenograft mouse model. After 3 weeks of PP242 treatment, a reduction in tumor size and weight was observed without any critical toxicities. According to results, metabolic changes due to the effects of PP242 were not significant in plasma. In contrast, metabolic changes in tumor tissues were very significant in the PP242-treated group compared to the xenograft control (XC) group, and revealed that energy and lipid metabolism were mainly altered by PP242 treatment like other cancer inhibitors. Additionally, in this study, it was discovered that not only TCA cycle but also fatty acid β-oxidation (β-FAO) for energy metabolism was inhibited and clear reduction in glycerophospholipid was observed. This study reveals new insights into the underlying anticancer mechanism of the dual mTOR inhibitor PP242, and could help further to facilitate the understanding of PP242 effects in the clinical application.

scholarly journals Antitumor Effects and Immunomodulating Activities ofPhellinus linteusExtract in a CT-26 Cell-Injected Colon Cancer Mouse Model

Mycobiology ◽  
2009 ◽  
Vol 37 (2) ◽  
pp. 128 ◽  
Author(s):  
Byung-Keun Yang ◽  
Seung-Lark Hwang ◽  
Ik-Jin Yun ◽  
Eun-Ju Do ◽  
Won-Ha Lee ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mouse Model ◽  
Antitumor Effects

Sa1108 SERUM AMYLOID A PROMOTES INFLAMMATION-ASSOCIATED DAMAGE, MACROPHAGE INFILTRATION AND TUMORIGENESIS IN A MOUSE MODEL OF COLITIS-ASSOCIATED COLON CANCER

2020 ◽  
Vol 158 (6) ◽  
pp. S-278
Author(s):  
Tanja Davis ◽  
Daleen Conradie ◽  
Preetha Shridas ◽  
Marcielle C. de Beer ◽  
Frederick c. de Beer ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mouse Model ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Macrophage Infiltration ◽  
Amyloid A

scholarly journals Linking inflammation to tumorigenesis in a mouse model of high-fat-diet-enhanced colon cancer

Cytokine ◽  
2013 ◽  
Vol 64 (1) ◽  
pp. 454-462 ◽  
Author(s):  
Stani D. Day ◽  
Reilly T. Enos ◽  
Jamie L. McClellan ◽  
J.L. Steiner ◽  
Kandy T. Velázquez ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mouse Model ◽  
High Fat Diet ◽  
High Fat

scholarly journals Combination of oncolytic adenovirus and luteolin exerts synergistic antitumor effects in colorectal cancer cells and a mouse model

2017 ◽  
Vol 16 (6) ◽  
pp. 9375-9382 ◽  
Author(s):  
Boduan Xiao ◽  
Yun Qin ◽  
Chang Ying ◽  
Buyun Ma ◽  
Binrong Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Cancer Cells ◽  
Oncolytic Adenovirus ◽  
Antitumor Effects ◽  
Colorectal Cancer Cells

scholarly journals Musa balbisiana and Musa paradisiaca Starches Increase SCFA and Caspase-3 as well as Decrease β-glucuronidase and MDA of Mouse Model for Colon Cancer

2021 ◽  
Vol 13 (1) ◽  
pp. 91-6
Author(s):  
Diana Nur Afifah ◽  
Fauzia Purnamasari ◽  
Luthfiatul Khusna ◽  
Noviasti Rahma Utami ◽  
Aida Fitri Nazillah ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mouse Model ◽  
Resistant Starch ◽  
Caspase 3 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Musa Balbisiana ◽  
Chromatography Analysis ◽  
Musa Paradisiaca ◽  
Gas Chromatography Analysis ◽  
Low Glycemic Index

BACKGROUND: Administration of resistant starch (RS) influences the diversity and the composition of microbiota as well as inhibits the growth of cancer cell. Banana as a potential source of RS has been reported. Although Musa paradisiaca has been reported to induce apoptosis in colon cancer cells, Musa balbisiana, which has low glycemic index and suitable for particular patients, has not been investigated yet.METHODS: Starches of M. balbisiana and M. paradisiaca were prepared and mixed with other components to make 3 types of mouse pellets. Mouse model for colon cancer was prepared and fed with different types of mouse pellets. Blood was collected and processed for measuring β-glucuronidase and malondialdehyde (MDA) with Enzyme-linked Immunosorbent Assay (ELISA) method. Resected ceca were incised to collect the inner part for short-chain fatty acid (SCFA) measurement with gas chromatography analysis. Resected colas were fixed and processed for immunohistochemistry to detect Caspase-3.RESULTS: Colon-cancer-mice fed with the M. balbisiana and M. paradisiaca starches-contained pellets had significant higher concentrations of total SCFA (p=0.003), acetic acid (p=0.000), propionic acid (p=0.000) and butyric acid (p=0.000); lower concentration of β-glucuronidase (p<0.001); higher Caspase-3 score (p=0.040); and lower MDA concentration (p<0.001) than colon-cancer-mice fed with standard pellet (control).CONCLUSION: M. balbisiana and M. paradisiaca starches could be suggested as potential anti-colon cancer RS. Further research should be carried out to disclose the starches mechanisms in colon cancer cell.KEYWORDS: Musa balbisiana, Musa paradisiaca, colon cancer, resistant starch, Caspase-3, SCFA, β-glucuronidase, malondialdehyde

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