scholarly journals Radiofrequency Ablation Combined with KS-IL2 Immunocytokine (EMD 273066) Results in an Enhanced Antitumor Effect against Murine Colon Adenocarcinoma

2009 ◽  
Vol 15 (15) ◽  
pp. 4875-4884 ◽  
Author(s):  
Erik E. Johnson ◽  
Brett H. Yamane ◽  
Ilia N. Buhtoiarov ◽  
Hillary D. Lum ◽  
Alexander L. Rakhmilevich ◽  
...  
2013 ◽  
Vol 217 (3) ◽  
pp. S127
Author(s):  
Karen K. Lo ◽  
Carlton C. Barnett ◽  
Sean P. Colgan ◽  
Richard D. Schulick ◽  
Denis D. Bensard ◽  
...  

Gene Therapy ◽  
2014 ◽  
Vol 22 (1) ◽  
pp. 29-39 ◽  
Author(s):  
P F Forde ◽  
L J Hall ◽  
M de Kruijf ◽  
M G Bourke ◽  
T Doddy ◽  
...  

2007 ◽  
Vol 139 (2) ◽  
pp. 164-169 ◽  
Author(s):  
Angela M. Jack ◽  
Nebil Aydin ◽  
Grace Montenegro ◽  
Khorshed Alam ◽  
Marc Wallack

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 215-215
Author(s):  
Flavien Devun ◽  
Julian Biau ◽  
Jian-sheng Sun ◽  
Alban Denys ◽  
Marie Dutreix

215 Background: Most of the patients with advanced colorectal cancer will develop liver metastasis, even after primary tumor resection. Although surgical resection remains the gold standard treatment of hepatic metastases, only few patients are eligible to curative resection. Radiofrequency ablation (RFA) is the most common curative alternative. Dbait are new molecules that inhibit DNA double-strand breaks repair. In vitro, Dbait has shown to increase cell death after hyperthermia. Here, we have assessed the combination of Dbait and RFA in the treatment of human colorectal cancer model xenografted in nude mice. Methods: 98 mice were flank-grafted with HT29 (human colon adenocarcinoma). When tumor reached 500 mm3, mice were sham treated (n=19), treated by Dbait via local injections (n=20), treated by RFA using an incomplete ablation scheme (n=20) or treated by combination of Dbait and RFA (n=39 separated in two Dbait regimens). After RFA, 39 mice were sacrificed for blinded pathological study, and 59 others were followed for survival analysis. Results: Mice treated by RFA-Dbait had significantly longer survival as compared to RFA alone (median survival: 56 vs 39 days, p<0.05) while RFA improved survival as compared to controls (median survival: 39 vs 28 days, p<0.05). Pathological studies of tumor slice have demonstrated significant decrease of tumor area and cancer cell viability in the RFA-Dbait group. Conclusions: While the implication of DNA repair activity in heat sensitivity remains unclear, our results show that the addition of Dbait to RFA enhances the antitumor response in this model and provide an experimental basis for the use of Dbait as an additional therapy to RFA. [Table: see text]


2015 ◽  
Vol 126 ◽  
pp. 163-171 ◽  
Author(s):  
Teresa Núñez de Villavicencio-Díaz ◽  
Yassel Ramos Gómez ◽  
Brizaida Oliva Argüelles ◽  
Julio R. Fernández Masso ◽  
Arielis Rodríguez-Ulloa ◽  
...  

1996 ◽  
Vol 87 (1) ◽  
pp. 78-85 ◽  
Author(s):  
Keita Sakata ◽  
Ken-ichi Kozaki ◽  
Ken-ichi Iida ◽  
Rie Tanaka ◽  
Sadako Yamagata ◽  
...  

2014 ◽  
Vol 187 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Kenton Howard ◽  
Karen K. Lo ◽  
Lihua Ao ◽  
Fabia Gamboni ◽  
Barish H. Edil ◽  
...  

1990 ◽  
Vol 46 (1) ◽  
pp. 118-124
Author(s):  
Yoshikazu Sugimoto ◽  
Tomoko Oh-hara ◽  
Yuji Heike ◽  
Masahiko Watanabe ◽  
Yoko Nakatsuru ◽  
...  

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