Abstract B119: Relationship of NaPi2b expression and efficacy of XMT-1536, a NaPi2b targeting antibody-drug conjugate (ADC), in an unselected panel of human primary ovarian mouse xenograft models

Mapping Intimacies ◽

10.1158/1535-7163.targ-17-b119 ◽

2018 ◽

Author(s):

Rebecca Mosher ◽

Laura Poling ◽

LiuLiang Qin ◽

Natalya Bodyak ◽

Donald Bergstrom

Keyword(s):

Antibody Drug Conjugate ◽

Mouse Xenograft ◽

Drug Conjugate ◽

Xenograft Models ◽

Relationship Of ◽

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Abstract 2726: Efficacy and candidate biomarker evaluation for the anti-mesothelin antibody drug conjugate (ADC) BAY 94-9343, mesothelin-ADC in mesothelin-positive preclinical xenograft models

10.1158/1538-7445.am2012-2726 ◽

2012 ◽

Author(s):

Christoph A. Schatz ◽

Sven Golfier ◽

Claudia Scheider ◽

Charlotte Kopitz ◽

Kerstin Berhörster ◽

...

Keyword(s):

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Xenograft Models ◽

Biomarker Evaluation ◽

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Abstract 3916: Relationship of guanylyl cyclase C (GCC) expression and efficacy of TAK-164, a GCC-targeted antibody-drug conjugate in a panel of 68 subcutaneous HuPrime colorectal cancer PDX models

10.1158/1538-7445.am2018-3916 ◽

2018 ◽

Author(s):

Erik M. Koenig ◽

Cong Li ◽

Huyuan Yang ◽

Andy Zhu ◽

Pooja Shah ◽

...

Keyword(s):

Colorectal Cancer ◽

Guanylyl Cyclase ◽

Guanylyl Cyclase C ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Relationship Of ◽

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Abstract 4820: Pediatric preclinical testing consortium evaluation of the CD123 antibody drug conjugate, IMGN632, against xenograft models of pediatric acute lymphoblastic leukemia

10.1158/1538-7445.sabcs18-4820 ◽

2019 ◽

Author(s):

Kathryn Evans ◽

Narimanne El-Zein ◽

Connor Jones ◽

Stephen W. Erickson ◽

Yuelong Guo ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Lymphoblastic Leukemia ◽

Antibody Drug Conjugate ◽

Preclinical Testing ◽

Pediatric Acute Lymphoblastic Leukemia ◽

Drug Conjugate ◽

Xenograft Models ◽

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Relationship of pharmacokinetics (PK), toxicity, and initial evidence of clinical activity with IMGN853, a folate receptor alpha (FRa) targeting antibody drug conjugate in patients (Pts) with epithelial ovarian cancer (EOC) and other FRa-positive solid tumors.

Journal of Clinical Oncology ◽

10.1200/jco.2014.32.15_suppl.5571 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. 5571-5571 ◽

Author(s):

Kathleen N. Moore ◽

Joseph Ponte ◽

Patricia LoRusso ◽

Michael J. Birrer ◽

Todd Michael Bauer ◽

...

Keyword(s):

Ovarian Cancer ◽

Epithelial Ovarian Cancer ◽

Solid Tumors ◽

Folate Receptor ◽

Clinical Activity ◽

Antibody Drug Conjugate ◽

Receptor Alpha ◽

Drug Conjugate ◽

Relationship Of ◽

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Abstract PR12: MLN0264, an investigational, first-in-class antibody-drug conjugate (ADC) targeting guanylyl cyclase C (GCC), demonstrates antitumor activity alone and in combination with gemcitabine in human pancreatic cancer xenograft models expressing GCC.

10.1158/1535-7163.targ-13-pr12 ◽

2013 ◽

Author(s):

Julie Zhang ◽

Melissa Gallery ◽

Tim Wyant ◽

Brad Stringer ◽

Mark Manfredi ◽

...

Keyword(s):

Pancreatic Cancer ◽

Antitumor Activity ◽

Guanylyl Cyclase ◽

Human Pancreatic Cancer ◽

Guanylyl Cyclase C ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Xenograft Models ◽

Class Antibody ◽

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Evaluation of TAK-264, an Antibody-Drug Conjugate in Pancreatic Cancer Cell Lines and Patient-Derived Xenograft Models

Clinical Cancer Drugs ◽

10.2174/2212697x05666180516120907 ◽

2018 ◽

Vol 5 (1) ◽

pp. 42-49 ◽

Author(s):

Anna R. Schreiber ◽

Anna Nguyen ◽

Stacey M. Bagby ◽

John J. Arcaroli ◽

Betelehem W. Yacob ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cancer Cell ◽

Pancreatic Cancer Cell ◽

Cancer Cell Lines ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Patient Derived Xenograft ◽

Xenograft Models ◽

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Abstract NT-113: SC-003, AN ANTIBODY-DRUG CONJUGATE TARGETING DIPEPTIDASE 3, EXHIBITS POTENT ANTI-TUMOR ACTIVITY IN PATIENT-DERIVED XENOGRAFT MODELS OF HIGH GRADE SEROUS OVARIAN CANCER

10.1158/1557-3265.ovcasymp18-nt-113 ◽

2019 ◽

Author(s):

Wolf R. Wiedemeyer ◽

Sheila Bheddah ◽

Christine Saechao ◽

Dorothy French ◽

Erik Huntzicker ◽

...

Keyword(s):

Ovarian Cancer ◽

Serous Ovarian Cancer ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Patient Derived Xenograft ◽

Xenograft Models ◽

Anti Tumor Activity ◽

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Abstract 4649: Using pharmacokinetic/efficacy modeling to identify the optimal schedule for MLN0264, an anti- guanylyl cyclase C (GCC) antibody-drug conjugate, in a range of xenograft models

10.1158/1538-7445.am2014-4649 ◽

2014 ◽

Author(s):

Shu-Wen Teng ◽

Christopher Zopf ◽

Johnny Yang ◽

Brad Stringer ◽

Julie Zhang ◽

...

Keyword(s):

Guanylyl Cyclase ◽

Optimal Schedule ◽

Guanylyl Cyclase C ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Xenograft Models ◽

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Targeting the 5T4 oncofetal glycoprotein with an antibody drug conjugate (A1mcMMAF) improves survival in patient-derived xenograft models of acute lymphoblastic leukemia

Haematologica ◽

10.3324/haematol.2016.158485 ◽

2017 ◽

Vol 102 (6) ◽

pp. 1075-1084 ◽

Author(s):

Owen J. McGinn ◽

Shekhar Krishnan ◽

Jean-Pierre Bourquin ◽

Puja Sapra ◽

Clare Dempsey ◽

...

Keyword(s):

Acute Lymphoblastic Leukemia ◽

Lymphoblastic Leukemia ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Patient Derived Xenograft ◽

Xenograft Models ◽

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Abstract 1234: An antibody-drug conjugate targeting tissue factor with broad anti-tumor efficacy in xenograft models with heterogeneous tissue factor expression.

10.1158/1538-7445.am2013-1234 ◽

2013 ◽

Author(s):

Esther C.W. Breij ◽

David Satijn ◽

Sandra Verploegen ◽

Bart E. de Goeij ◽

Danita H. Schuurhuis ◽

...

Keyword(s):

Tissue Factor ◽

Tissue Factor Expression ◽

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Factor Expression ◽

Xenograft Models ◽

Heterogeneous Tissue ◽

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