Abstract 32: Lynch syndrome-associated breast cancers: Clinicopathological characteristics of a case series from the Colon CFR

2010 ◽  
Author(s):  
Christophe Rosty ◽  
Michael Walsh ◽  
Margaret Cummings ◽  
Daniel Buchanan ◽  
Sven Arnold ◽  
...  
Keyword(s):  
Lynch Syndrome ◽  
Case Series ◽  
Clinicopathological Characteristics ◽  
Breast Cancers

scholarly journals Lynch Syndrome–Associated Breast Cancers: Clinicopathologic Characteristics of a Case Series from the Colon Cancer Family Registry

2010 ◽  
Vol 16 (7) ◽  
pp. 2214-2224 ◽  
Author(s):  
Michael D. Walsh ◽  
Daniel D. Buchanan ◽  
Margaret C. Cummings ◽  
Sally-Ann Pearson ◽  
Sven T. Arnold ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lynch Syndrome ◽  
Case Series ◽  
Breast Cancers ◽  
Clinicopathologic Characteristics ◽  
Cancer Family ◽  
Colon Cancer Family Registry

scholarly journals Gastric Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: A Western Center Case Series

2021 ◽  
Vol 9 (3) ◽  
pp. 47
Author(s):  
Marcus Fernando Kodama Pertille Ramos ◽  
Marina Alessandra Pereira ◽  
Arthur Youssif Mota Arabi ◽  
Melissa Mello Mazepa ◽  
Andre Roncon Dias ◽  
...  
Keyword(s):  
Gastric Adenocarcinoma ◽  
Tumor Size ◽  
Lymphovascular Invasion ◽  
Comparison Group ◽  
Case Series ◽  
Clinicopathological Characteristics ◽  
Neuroendocrine Neoplasms ◽  
Rare Tumor ◽  
Term Survival

Background: Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) represent a rare tumor composed of adenocarcinoma and neuroendocrine carcinoma components. This study reports a case series of gastric MiNEN and discusses issues related to its diagnosis, management, and outcomes. Methods: We retrospectively analyzed data from patients with gastric MiNEN who underwent surgical resection at our service from 2009 to 2020. Patients with gastric adenocarcinoma served as a comparison group. Clinical, pathologic, and surgical characteristics were compared. Results: During the selected period, 5 gastric MiNEN patients and 597 patients with gastric adenocarcinoma were included. Among the clinical variables, age, sex, BMI, and laboratory exams were similar between the two groups. Only ASA classification was different (p = 0.015). Pathological variables such as tumor size, lymphovascular invasion, number of retrieved lymph nodes, and pTNM staging were also similar between both groups. Lastly, early surgical outcomes and long-term survival did not differ between gastric MiNEN and adenocarcinoma patients. Conclusion: A MiNEN is a rare tumor that represents less than 1% of GC patients undergoing curative treatment, and demonstrated clinicopathological characteristics and outcomes similar to gastric adenocarcinoma.

Morphological and genomic characteristics of breast cancers occurring in individuals with Lynch Syndrome

2021 ◽  
pp. clincanres.2027.2021
Author(s):  
Christopher J. Schwartz ◽  
Edaise M. da Silva ◽  
Antonio Marra ◽  
Andrea M. Gazzo ◽  
Pier Selenica ◽  
...  
Keyword(s):  
Lynch Syndrome ◽  
Breast Cancers

scholarly journals Endoscopic submucosal dissection in management of colorectal tumors near or involving a diverticulum: a retrospective case series

2019 ◽  
Vol 07 (05) ◽  
pp. E664-E671 ◽  
Author(s):  
Victoria Jimenez-Garcia ◽  
Masayoshi Yamada ◽  
Hiroaki Ikematsu ◽  
Hiroyuki Takamaru ◽  
Seiichiro Abe ◽  
...  
Keyword(s):  
Endoscopic Submucosal Dissection ◽  
Case Series ◽  
Clinicopathological Characteristics ◽  
R0 Resection ◽  
Incomplete Resection ◽  
Colorectal Tumors ◽  
Resection Rate ◽  
Retrospective Case ◽  
En Bloc ◽  
Submucosal Dissection

Abstract Background and study aims Surgery is the standard treatment for colon tumors associated with diverticulum. Use of endoscopic submucosal dissection (ESD) to treat such tumors is controversial. The aim of this study was to assess the safety and feasibility of ESD in treating superficial colorectal tumors situated near or involving diverticulum. Patients and methods Consecutive patients from two referral centers who had colorectal tumors near or involving diverticulum treated by ESD were retrospectively studied. Clinicopathological characteristics and clinical outcomes were analyzed. Results Of the 12 patients studied, six had tumors near diverticulum and six had tumors involving diverticulum. The overall en-bloc R0 resection rate, median tumor size and procedure time were 67 %, 26.5 mm (range, 15 – 80 mm) and 110 minutes (range, 50 – 220 minutes), respectively. For tumors near diverticulum group, the en-bloc R0 resection rate was 100 % and no adverse events (AEs) or residual/recurrent tumors were observed. In contrast, for intradiverticular tumors group, the en-bloc R0 resection rate was low at 33 %, and one AE (perforation) was observed. The diverticula were ≥ 6 mm in diameter in the patients with incomplete resection. However, all but one diverticulum was unrecognized before ESD. Two residual tumors were detected at the 12-month surveillance and one required surgery. Conclusions This case series indicates that ESD is safe and feasible for treating colorectal tumors near a diverticulum and might be feasible for tumors involving a diverticulum smaller than 6 mm. Selection for smaller diverticulum size may contribute to higher en-bloc R0 resection rates.

scholarly journals Ultrasound and Clinicopathological Characteristics of Triple Receptor-Negative Breast Cancers

2011 ◽  
Vol 14 (2) ◽  
pp. 119 ◽  
Author(s):  
Yoon Jung Choi ◽  
Min Hyun Seong ◽  
Seon Hyeong Choi ◽  
Shin Ho Kook ◽  
Hyon Joo Kwag ◽  
...  
Keyword(s):  
Clinicopathological Characteristics ◽  
Breast Cancers

Clinicopathological Characteristics of Breast Cancers with Axillary Skip Metastases

2012 ◽  
Vol 25 (1) ◽  
pp. 33-36 ◽  
Author(s):  
Jingyan Sun ◽  
Jian Yin ◽  
Liansheng Ning ◽  
Juntian Liu ◽  
Hong Liu ◽  
...  
Keyword(s):  
Clinicopathological Characteristics ◽  
Breast Cancers ◽  
Skip Metastases

scholarly journals Changes in the Demographic and Clinicopathological Characteristics of Thyroid Cancer: A Population-Based Investigation in Algeria, 1993-2013

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Houda Boukheris ◽  
Arslan Bettayeb ◽  
Lesley Ann Anderson ◽  
Zineb Achour ◽  
Fatma Zohra Benbachir ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Case Series ◽  
Population Based ◽  
Clinicopathological Characteristics ◽  
Nutrition Status ◽  
Iodine Nutrition ◽  
Molecular Features ◽  
International Trends ◽  
Histologic Types ◽  
Over Time

Over the last three decades, the incidence of thyroid cancer has increased worldwide. The reasons for this increase remain controversial. In Algeria, however, to date, information on thyroid cancer has been limited to a hospital-based case series. We analyzed data from a population-based cohort study in Oran District, Algeria, to describe demographic and clinicopathological characteristics of patients diagnosed with thyroid cancer between 1993 and 2013. Medical records and pathology reports of thyroid cancer patients who had surgery were reviewed. Changes in demographic and clinicopathological features over the 21-year period are described. During the study period, thyroid cancer was diagnosed in 1248 women (86.5%, mean age 43.7±15.2 years) and 195 men (23.4%, mean age 48.1±15.9 years). Most cases (83.1% for women and 69.8% for men) sought a diagnosis following a self-neck check. The most common histologic types were papillary (58.3%), follicular (29.7%), anaplastic (4.1%), and medullary (0.8%) carcinomas. The incidence of papillary carcinomas significantly increased (p<0.001) while the incidence of other histologic types significantly decreased over time. Tumor size overall significantly decreased (p<0.001) while the frequency of small (≤20 mm) and larger (>20 mm) carcinomas significantly increased (p<0.05). The frequency of thyroid cancers with capsular effractions and angioinvasions also decreased over time. Thyroid cancer incidence in Algeria has increased substantially in line with international trends with changes in clinical practice being a possible contributing factor. However, the increasing papillary-to-follicular cancer ratio may be due to changes in iodine nutrition status in Algeria. Further research, including exploration of biological and molecular features of thyroid cancer, will enable a better understanding of risk factors and etiopathogenetic mechanisms.

Clinical findings and outcomes from MRI staging of breast cancers in women.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1124-1124
Author(s):  
Akshara Raghavendra ◽  
Charite Nicolette Ricker ◽  
Lingyun Ji ◽  
Terry Church ◽  
Sujie Tang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Underserved Populations ◽  
Preoperative Staging ◽  
Case Series ◽  
Comprehensive Cancer Center ◽  
Cancer Center ◽  
Minority Population ◽  
Breast Cancers ◽  
Mri Staging

1124 Background: For patients diagnosed with breast cancer, case series have shown that staging MRI can detect occult breast cancers in 1-10% of cases. Prevalence and risk factors in underserved populations remain unclear. Methods: We performed a retrospective analysis of all patients, newly diagnosed, with breast cancer who had a preoperative staging MRI seen at Norris Comprehensive Cancer Center and LAC +USC, that cares for an underserved and minority population, from 2006 to 2011. Demographic, clinicopathologic and imaging data were obtained through a review of electronic records. Non index lesions were defined as those not known to be malignant, not presenting with clinical, mammographic or ultrasound findings, in a different quadrant and given an MRI BIRADS score of 4 or 5. Results: A total of 718 patients were analyzed and 148 patients (21%) had a total of 187 non index lesions; 63% were ipsilateral, 26% contralateral and 11% bilateral. As initial evaluation of non-index ipsilateral lesions, 71 (38%) had biopsy, 24 (13%) had excision and 34 (18%) had mastectomy. For contralateral non-index lesions, 41 (22%) had contralateral biopsy, 6 (3%) had excision and 11(6%) had mastectomy. Among all non index lesions, 111 (59%) were benign, 14 (7%) DCIS and 62 (33%) invasive cancer. Occult ipsilateral cancer was detected in 50 (6.9%) of patients and contralateral in 10 (1.4%) and bilateral in 6 (0.8%). Conclusions: The occult cancer detection rate with staging MRI was in this 9.2% of this diverse population. No clear risk factors were identified, with detailed factors, including BRCA status to be updated and reanalyzed. [Table: see text]

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