Abstract 182: Tumor suppressor microRNA-493 decreases cell motility and migration ability in human bladder cancer cells by down-regulating RhoC and FZD4

2012 ◽  
Author(s):  
Koji Ueno ◽  
Hiroshi Hirata ◽  
Shahana Majid ◽  
Soichiro Yamamura ◽  
Varahram Shahryari ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Cell Motility ◽  
Cancer Cells ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Migration Ability ◽  
Bladder Cancer Cells ◽  
And Migration ◽  
Human Bladder Cancer Cells

scholarly journals Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN

2013 ◽  
Vol 14 (11) ◽  
pp. 21215-21226 ◽  
Author(s):  
Feng Xie ◽  
Ming Su ◽  
Wei Qiu ◽  
Min Zhang ◽  
Zhongqiang Guo ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells

scholarly journals miR-99a acts as tumor suppressor via targeting to MTOR in human bladder cancer cells

2015 ◽  
Vol 26 (2) ◽  
pp. S44-S45
Author(s):  
Kuang-Yu Chou ◽  
Ji-Fan Lin ◽  
Te-Fu Tsai ◽  
Hung-En Chen ◽  
Yi-Chia Lin ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells

Guggulsterone Induces Apoptosis and Inhibits Lysosomal-Dependent Migration in Human Bladder Cancer Cells

2020 ◽  
Author(s):  
Ying Chen ◽  
Hisao-Hsien Wang ◽  
Hsin-Han Chang ◽  
Yun-Hsuan Huang ◽  
Jeffrey R. Wang ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Survival Rate ◽  
Cancer Cells ◽  
Low Grade ◽  
High Grade ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Migration Ability ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells

The survival rate and therapeutic options of bladder cancer patients have improved little in recent decades. Guggulsterone (GS), a phytoestrogen, has been investigated as an anticancer drug in various malignancies. The present study aimed to evaluate the anticancer effect of E-isomer and Z-isomer GS in the human bladder cancer cell lines TSGH8301 (low-grade) and T24 (high-grade) and its underlying mechanisms. E-isomer GS reduced the survival rate in both low- and high-grade human bladder cancer cells. Colony formation was inhibited after GS treatment. Moreover, cell cycle arrest accompanied by reduced cyclin A, increased p21 and caspase-dependent apoptosis was observed upon GS treatment. Moreover, GS treatment downregulated p-mTOR, mTOR, p-Akt and LC3expression in bladder cancer cells. In addition, GS reduced migration ability with a decrease in integrin-focal adhesion kinase (FAK) and myosin light chain (MLC). The GS-mediated migration suppression was prevented by the lysosomal inhibitor NH4Cl in human bladder cancer cells. Current findings suggest that GS treatment may serve as a potential anticancer therapy for both low- and high-grade urothelial carcinoma.

scholarly journals MP36-10 MIR-99A ACTS AS TUMOR SUPPRESSOR VIA TARGETING TO MTOR IN HUMAN BLADDER CANCER CELLS

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Te-Fu Tsai ◽  
Ji-Fan Lin ◽  
Yi-Chia Lin ◽  
Kuang-Yu Chou ◽  
Hung-En Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells
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