Abstract 4937: KIF3A promotes prostate cancer cell proliferation, migration, and invasion via activation of Dvl2 and the Wnt signaling pathway.

2013 ◽  
Author(s):  
Zun Liu ◽  
Ryan E. Rebowe ◽  
Zemin Wang ◽  
Zehua Wang ◽  
John S. DePaolo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Wnt Signaling Pathway ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation

scholarly journals Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Yun Luo ◽  
Jie-Ying Wu ◽  
Min-Hua Lu ◽  
Zhi Shi ◽  
Ning Na ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Signaling Pathways ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Mapk Signaling ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation ◽  
Du145 Cells ◽  
Mapk Signaling Pathways

TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells. Our results showed that carvacrol blocked TRPM7-like currents in PC-3 and DU145 cells and reduced their proliferation, migration, and invasion. Moreover, carvacrol treatment significantly decreased MMP-2, p-Akt, and p-ERK1/2 protein expression and inhibited F-actin reorganization. Furthermore, consistently, TRPM7 knockdown reduced prostate cancer cell proliferation, migration, and invasion as well. Our study suggests that carvacrol may have therapeutic potential for the treatment of prostate cancer through its inhibition of TRPM7 channels and suppression of PI3K/Akt and MAPK signaling pathways.

scholarly journals miR-19a-3p targets PMEPA1 and induces prostate cancer cell proliferation, migration and invasion

2016 ◽  
Vol 13 (5) ◽  
pp. 4030-4038 ◽  
Author(s):  
SUJUAN FENG ◽  
XUHUI ZHU ◽  
BOHAN FAN ◽  
DAWEI XIE ◽  
TAO LI ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Migration And Invasion ◽  
Cancer Cell Proliferation
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