Abstract 3148: Identification and establishment of an 18-gene redox signature for recurrence prediction in colorectal cancer

2019 ◽  
Author(s):  
Priyanka Sharma ◽  
Jasjit K. Banwait ◽  
Luis Bujanda ◽  
Ajay Goel
Keyword(s):  
Colorectal Cancer ◽  
Recurrence Prediction

scholarly journals Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis

Open Biology ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 180212 ◽  
Author(s):  
Bing Chen ◽  
Zijing Xia ◽  
Ya-Nan Deng ◽  
Yanfang Yang ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Target Genes ◽  
Research Use ◽  
Biological Processes ◽  
Functional Roles ◽  
Analytical Technique ◽  
Diagnosis And Prognosis ◽  
Recurrence Prediction ◽  
Extracellular Mirnas ◽  
Non Coding Rnas

MicroRNAs (miRNAs) are one abundant class of small, endogenous non-coding RNAs, which regulate various biological processes by inhibiting expression of target genes. miRNAs have important functional roles in carcinogenesis and development of colorectal cancer (CRC), and emerging evidence has indicated the feasibility of miRNAs as robust cancer biomarkers. This review summarizes the progress in miRNA-related research, including study of its oncogene or tumour-suppressor roles and the advantages of miRNA biomarkers for CRC diagnosis, treatment and recurrence prediction. Along with analytical technique improvements in miRNA research, use of the emerging extracellular miRNAs is feasible for CRC diagnosis and prognosis.

scholarly journals Genome-wide Discovery and Identification of a Novel miRNA Signature for Recurrence Prediction in Stage II and III Colorectal Cancer

2018 ◽  
Vol 24 (16) ◽  
pp. 3867-3877 ◽  
Author(s):  
Raju Kandimalla ◽  
Feng Gao ◽  
Takatoshi Matsuyama ◽  
Toshiaki Ishikawa ◽  
Hiroyuki Uetake ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stage Ii ◽  
Mirna Signature ◽  
Novel Mirna ◽  
Genome Wide ◽  
Recurrence Prediction

scholarly journals Derivation and Clinical Validation of a Redox-Driven Prognostic Signature for Colorectal Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Qin Dang ◽  
Zaoqu Liu ◽  
Shengyun Hu ◽  
Zhuang Chen ◽  
Lingfang Meng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathways ◽  
Risk Score ◽  
Immune Cell ◽  
Risk Model ◽  
Prognostic Signature ◽  
Related Factors ◽  
Recurrence Prediction ◽  
Intimate Association

Colorectal cancer (CRC), a seriously threat that endangers public health, has a striking tendency to relapse and metastasize. Redox-related signaling pathways have recently been extensively studied in cancers. However, the study and potential role of redox in CRC remain unelucidated. We developed and validated a risk model for prognosis and recurrence prediction in CRC patients via identifying gene signatures driven by redox-related signaling pathways. The redox-driven prognostic signature (RDPS) was demonstrated to be an independent risk factor for patient survival (including OS and RFS) in four public cohorts and one clinical in-house cohort. Additionally, there was an intimate association between the risk score and tumor immune infiltration, with higher risk score accompanied with less immune cell infiltration. In this study, we used redox-related factors as an entry point, which may provide a broader perspective for prognosis prediction in CRC and have the potential to provide more promising evidence for immunotherapy.

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