Abstract 1945: Modulation of intracellular redox milieu regulates Mcl-1 levels and sensitizes venetoclax resistant cancer cells

2021 ◽  
Author(s):  
Jolin Xiao Lai ◽  
Shazib Pervaiz
Keyword(s):  
Cancer Cells ◽  
Intracellular Redox

Intracellular Redox Active Metal Ions Mediate the Differential Susceptibility of Lung and Brain Cancer Cells to Pharmacological Ascorbate

2014 ◽  
Vol 76 ◽  
pp. S131
Author(s):  
Joshua D Schoenfeld ◽  
Zita A. Sibenaller ◽  
Kranti A. Mapuskar ◽  
Joseph J. Cullen ◽  
Garry R. Buettner ◽  
...  
Keyword(s):  
Metal Ions ◽  
Cancer Cells ◽  
Brain Cancer ◽  
Differential Susceptibility ◽  
Redox Active ◽  
Active Metal ◽  
Redox Active Metal ◽  
Intracellular Redox

Intracellular redox state as determinant for melatonin antiproliferative vs cytotoxic effects in cancer cells

2011 ◽  
Vol 45 (11-12) ◽  
pp. 1333-1341 ◽  
Author(s):  
Ana M. Sánchez-Sánchez ◽  
Vanesa Martín ◽  
Guillermo García-Santos ◽  
Jezabel Rodríguez-Blanco ◽  
Sara Casado-Zapico ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Redox State ◽  
Cytotoxic Effects ◽  
Intracellular Redox

scholarly journals Nanofocused synchrotron X-ray absorption studies of the intracellular redox state of an organometallic complex in cancer cells

2019 ◽  
Vol 55 (49) ◽  
pp. 7065-7068 ◽  
Author(s):  
Carlos Sanchez-Cano ◽  
Diego Gianolio ◽  
Isolda Romero-Canelon ◽  
Remi Tucoulou ◽  
Peter J. Sadler
Keyword(s):  
Cancer Cells ◽  
Redox State ◽  
Intracellular Distribution ◽  
Organometallic Complex ◽  
X Ray ◽  
Absorption Studies ◽  
X Ray Absorption ◽  
Intracellular Redox

Synchrotron nanoprobe X-ray absorption studies of an osmium metallodrug in cancer cells show hetereogeneous intracellular distribution of OsII and OsIII species.

scholarly journals The intracellular redox environment modulates the cytotoxic efficacy of single and combination chemotherapy in breast cancer cells using photochemical internalisation

RSC Advances ◽  
2019 ◽  
Vol 9 (44) ◽  
pp. 25861-25874 ◽  
Author(s):  
Derick K. Adigbli ◽  
Hayley Pye ◽  
Jason Seebaluck ◽  
Marilena Loizidou ◽  
Alexander J. MacRobert
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Combination Chemotherapy ◽  
Breast Cancer Cells ◽  
Cytotoxic Agent ◽  
Redox Environment ◽  
Photochemical Internalization ◽  
Intracellular Redox

The redox environment modulates photochemical internalization of an entrapped cytotoxic agent. Administration of light depicted by jagged arrow.

Ultrastructural modification of cellular interactions in cancer tumor

1978 ◽  
Vol 36 (2) ◽  
pp. 318-319
Author(s):  
N. P. Dmitrieva
Keyword(s):  
Cancer Cells ◽  
Human Thyroid ◽  
Adjacent Cell ◽  
Main Role ◽  
Cellular Interactions ◽  
Electron Microscopic ◽  
Cancer Tumor ◽  
Normal Human ◽  
Characteristic Features

One of the most characteristic features of cancer cells is their ability to metastasia. It is suggested that the modifications of the structure and properties of cancer cells surfaces play the main role in this process. The present work was aimed at finding out what ultrastructural features apear in tumor in vivo which removal of individual cancer cells from the cell population can provide. For this purpose the cellular interactions in the normal human thyroid and cancer tumor of this gland electron microscopic were studied. The tissues were fixed in osmium tetroxide and were embedded in Araldite-Epon.In normal human thyroid the most common type of intercellular contacts was represented by simple junction formed by the parallelalignment of adjacent cell membranees leaving in between an intermembranes space 15-20 nm filled with electronlucid material (Fig. 1a). Sometimes in the basal part of cells dilatations of the intercellular space 40-50 nm wide were found (Fig. 1a). Here the cell surfaces may form single short microvilli.

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