Abstract P2-08-30: The role of skeletal muscle volume on prognosis of breast cancer survivors using with cross-sectional image

Author(s):  
EJ Song ◽  
SJ Park ◽  
MH Lee ◽  
Y Kwon ◽  
KL Ko ◽  
...  
Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1301
Author(s):  
Saskia W. M. C. Maass ◽  
Daan Brandenbarg ◽  
Liselotte M. Boerman ◽  
Peter F. M. Verhaak ◽  
Geertruida H. de Bock ◽  
...  

Background: Fatigue is the most common and persistent symptom among women in the first five years after a breast cancer diagnosis. However, long-term prevalence of fatigue, among breast cancer survivors, needs further investigation. Aim: To compare fatigue experienced by long-term breast cancer survivors with that in a reference population and to evaluate the determinants of that fatigue. Design and Setting: A cross-sectional cohort study of 350 breast cancer survivors ≥5 years after diagnosis and a reference population of 350 women matched by age and general practitioner. Method: Fatigue was measured using the Multidimensional Fatigue Inventory (MFI-20), and a sum score of >60 (multidimensional fatigue) was the primary outcome. Logistic regression was applied to compare the prevalence of multidimensional fatigue between the survivor and reference populations, adjusted for body mass index (BMI) and for cardiovascular and psychological variables. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were estimated. Logistic regression was applied to evaluate the determinants of multidimensional fatigue among the survivors. Results: Breast cancer survivors (median 10 years after diagnosis), more often experienced multidimensional fatigue than the reference population (26.6% versus 15.4%; OR, 2.0 [95%CI, 1.4–2.9]), even after adjusting for confounders. The odds of multidimensional fatigue were also higher among survivors with symptoms of depression (32.2% versus 2.7%; OR, 17.0 [95%CI, 7.1–40.5]) or anxiety (41.9% versus 10.1%; OR, 6.4 [95%CI, 3.6–11.4]). Conclusion: One in four breast cancer survivors experience multidimensional fatigue and fatigue occurs more frequently than in women of the same age and general practitioner. This fatigue appears to be associated with symptoms of depression and anxiety.


2020 ◽  
Author(s):  
Jong Won Lee ◽  
Jihyoun Lee ◽  
Min Hyuk Lee ◽  
Se Kyung Lee ◽  
Wan Sung Kim ◽  
...  

Abstract Backgroud: As the survival rates of cancer patients have been increasing due to early diagnosis and technological advances in treatment, their caregiver burden has also emerged as an important issue. In view of this situation, this study aims to investigate the unmet needs and quality of life of caregivers of Korean breast cancer survivors.Methods: A multicenter cross-sectional interview survey was performed among 160 caregivers of Korean breast cancer survivors. Caregivers who gave written informed consent to participate completed the Comprehensive Needs Assessment Tool for Cancer Caregivers and EuroQol-5 Dimensions. Data were analyzed using the t-test, ANOVA and multiple regression analysis.Results: The mean age of the caregivers was 46.4 years, 44.4% (71/160) were spouses of patients, and 52.5% (84/160) were personally taking care of cancer survivors. Unmet needs were highest in the ‘healthcare staff’ domain (mean ± SD: 1.69 ±1.11), and the item with the highest level of unmet needs was ‘needed information about the current status of the patient’s illness and its future courses’ (1.98 ± 1.04). Unmet needs were correlated with age, educational level, marital status, employment, religion and psychosocial status. Poorer quality of life was closely related to higher levels of unmet needs. In multiple regression analysis, age, employment, religion, and levels of stress and despair were closely associated with unmet needs.


2018 ◽  
Vol 36 ◽  
pp. 68-80 ◽  
Author(s):  
Irene de la Rosa-Díaz ◽  
María Torres-Lacomba ◽  
Paz Acosta-Ramírez ◽  
Itxaso García-de Orive ◽  
Robert J. Nee ◽  
...  

2014 ◽  
Author(s):  
Krista Highland ◽  
Alejandra Hurtado de Mendoza ◽  
Ocla Kigen ◽  
Vanessa B. Sheppard

2020 ◽  
Vol 22 (2) ◽  
pp. 436-444 ◽  
Author(s):  
Sureeporn Chumdaeng ◽  
Pratum Soivong ◽  
Hunsa Sethabouppha ◽  
Ratanawadee Chontawan

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Brandon Khuu ◽  
John Pierce ◽  
Tianying Wu

Abstract Objectives To determine the associations of processed and unprocessed red meat with serum C-reactive protein (CRP) and hemoblobin A1c (HbA1c) among breast cancer survivors. We hypothesized that processed and unprocessed red meat can increase CRP and HbA1c.These associations will not be completely mediated by body mass index (BMI). Methods Using a cross-sectional design, we analyzed data collected from 3088 breast cancer survivors who enrolled in the Women's Healthy Eating and Living (WHEL) Study and had provided four detailed 24-hour dietary recalls over a 3-week period along with a blood sample to validate dietary pattern and measure plasma CRP and HbA1c from washed red blood cells. Intakes of processed and unprocessed red meat were extracted from dietary recalls. CRP concentrations were measured using high-sensitivity electrochemiluminescence assay. HbA1C was measured using ion exchange high-performance liquid chromatography. Results We found significant positive associations for both unprocessed and processed red meat with plasma CRP and HbA1c. In multivariable adjusted models, compared to women with the lowest quintile intakes of unprocessed red meat, women with highest quintile had a 19% increase of CRP and had an 11% increase of HbA1c after adjustment for BMI. Further adjustment for total vegetable intake did not materially change these associations. We observed similar patterns for processed red meat. The magnitudes of the associations of processed red meat with CRP and HbA1c were similar to that of unprocessed meat with CRP and HbA1c after adjustment of BMI. P-values for trends were less than 0.002 for all of these associations. Conclusions CRP and HbA1c are strong predictors for breast cancer prognosis and development of comorbidities (e.g., diabetes). Although many studies examined the association of red meat with CRP and HbA1c in general healthy population, few studies were conducted among breast cancer survivors. Our results for the first time demonstrate that the positive associations between unprocessed and processed red meat consumption and inflammation and hyperglycemia are not fully mediated by BMI among breast cancer women. Funding Sources SDSU start-up funds.


The Breast ◽  
2020 ◽  
Vol 54 ◽  
pp. 133-138 ◽  
Author(s):  
S.W.M.C. Maass ◽  
L.M. Boerman ◽  
D. Brandenbarg ◽  
P.F.M. Verhaak ◽  
J.H. Maduro ◽  
...  

2016 ◽  
Vol 34 (3_suppl) ◽  
pp. 188-188
Author(s):  
Victoria Champion ◽  
Andrea A Cohee ◽  
Patrick Monahan ◽  
Timothy E. Stump ◽  
Kathy Miller ◽  
...  

188 Background: Although breast cancer is more commonly diagnosed in post-menopausal women, there are a significant number of survivors diagnosed at age 45 or younger. Compared to older survivors, younger survivors have significantly more problems with depression sexual functioning, marital satisfaction, and overall well-being, but there is little research on the partners of these younger survivors. The purpose of this study is to determine if the partners of young survivors experience more problems with depression, sexual functioning, marital satisfaction, and overall well-being than partners of age-matched controls. Methods: Survivors and partners (n=227) were enrolled in a large cross-sectional study, executed through the ECOG-ACRIN Cancer Research Group. Eligibility for survivors included being 45 or under at diagnosis, 3 to 8 years from treatment without a breast cancer recurrence, and with similar chemotherapy treatment regimens. Survivors identified age-matched acquaintance controls without breast cancer. These age matched controls and their partners (n=170) were also included. All groups completed a survey assessing demographic characteristics, depression, sexual functioning (enjoyment and difficulty), marital satisfaction, and overall well-being. The partners of both young survivors and acquaintance controls were compared on all study variables adjusting for demographic variables. Results: Partners of young survivors reported significantly more depression (effect size [ES] = -0.23, p=.0199), worse sexual functioning as indicated by lower enjoyment (ES= 0.32, p=.0019) and more sexual difficulty (ES= -0.24, p=.0164), lower marital satisfaction (ES=0.24, p=.0189), and lower overall well-being (ES= 0.40, p=.0001). Conclusions: Partners of breast cancer survivors suffer from problems similar to breast cancer survivors. Further research is needed to fully understand the impact of a breast cancer diagnosis on both the partner as well as the survivor, especially when problems exist that are related to the dyadic relationship.


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