Abstract P3-12-12: Serum estrogen-levels in women 48-56yrs with hormone receptor-positive breast cancer. Cross-Sectional study using an ultra-sensitive LC-MS/MS-method

2018 ◽  
Author(s):  
M Van Houdt ◽  
P Neven ◽  
L Anneleen ◽  
J Ivo ◽  
V Dirk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hormone Receptor Positive ◽  
Positive Breast Cancer

scholarly journals Comparison of Grading and ER, PR Hormone Receptor Status of Carcinoma Breast in FNAC with Histopathology - A Cross Sectional Study from Thrissur, Kerala

2021 ◽  
Vol 8 (21) ◽  
pp. 1696-1700
Author(s):  
Suma Madathiveetil ◽  
Jisha Kalathil Thodiyil ◽  
Freena Rose
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Cross Sectional Study ◽  
Hormone Receptor Status ◽  
Sectional Study ◽  
Cross Sectional ◽  
Carcinoma Breast ◽  
Receptor Status ◽  
Common Cancer ◽  
Number Of Patients

BACKGROUND Breast cancer is now the most common cancer in cities in India and 2 nd most common cancer in the rural areas. Fine needle aspiration cytology (FNAC) is a less invasive pre-operative diagnostic method and is preferred over core / excision biopsy to decide the benign or malignant nature of the breast lump. Prognostic factor assessment by FNAC would allow the identification of patients who would benefit from neo adjuvant treatment (patients with grade 3 tumours) and in whom conservation surgery is inadvisable.1 The purpose of this study is to compare the grades of breast cancer in FNAC with histopathology as gold standard and compare the oestrogen (ER) and progesterone (PR) hormonal expression pattern on immunocytochemistry (ICC) with immunohistochemistry (IHC). From this study we intend to assess the usefulness of cytological grading and ER, PR hormone receptor status pre-operatively so that hormonal therapy can be included with neoadjuvant chemotherapy. METHODS This is a cross sectional study with a sample size of 50, conducted in the Department of Pathology. RESULTS Out of 50 cases, maximum number of patients were in the age group of 51 - 60 years. 68 % had attained menopause; 69 % of patients had tumour size between 2 - 5 cm and 90 % of tumours were in the upper outer quadrant of breast. Considering hormonal expression, in case of ER there was a moderate agreement between ICC and IHC (κ = .428, P = 0.005) and no agreement was seen in case of PR (κ = .073, P = 0.625). Regarding the cytological grading, this study showed highest degree of concordance with grade II tumours with a sensitivity of 75.9 %. For Grade I it was 2.5 % and for grade III, it was 33.3 %. CONCLUSIONS Evaluation of hormonal status and nuclear grading is fairly reliable on cytology when performed on qualitatively superior FNAC material from the primary breast lesions. KEYWORDS Carcinoma Breast, FNAC, ER / PR, Immunocytochemistry, Immunohistochemistry, Cytological Nuclear Grading

scholarly journals Response evaluation after primary systemic therapy of Her2 positive breast cancer – an observational cross-sectional study

2015 ◽  
Vol 56 (2) ◽  
pp. 128-138 ◽  
Author(s):  
Tímea Tőkés ◽  
Gyöngyvér Szentmártoni ◽  
László Torgyík ◽  
Kornélia Kajáry ◽  
Zsolt Lengyel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systemic Therapy ◽  
Cross Sectional Study ◽  
Response Evaluation ◽  
Sectional Study ◽  
Her2 Positive ◽  
Primary Systemic Therapy ◽  
Cross Sectional ◽  
Her2 Positive Breast Cancer ◽  
Positive Breast Cancer

scholarly journals First Prospective Cross-Sectional Study on the Impact of Immigration Background and Education in Early Detection of Breast Cancer

Breast Care ◽  
2020 ◽  
pp. 1-7
Author(s):  
Elna Kuehnle ◽  
Wulf Siggelkow ◽  
Kristina Luebbe ◽  
Iris Schrader ◽  
Karl-Heinz Noeding ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
First Generation ◽  
Participation Rate ◽  
Educational Status ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
First Generation Immigrants ◽  
Cancer Early Detection

<b><i>Background:</i></b> Although immigrant health is an important issue in national health policy, there is a serious shortage of data in many countries. Most studies lack information on educational status, which is a major limitation. This prospective cross-sectional study analyzed a real-world breast cancer population on the influence of immigration background and educational status on participation in breast cancer early detection programs in the federal state of Lower Saxony, Germany. <b><i>Methods:</i></b> Data collection was conducted from 2012 to 2016 in six certified breast cancer centers using a standardized questionnaire for patients’ interview and tumor-specific data from the patients’ medical records. <b><i>Results:</i></b> 2,145/3,047 primary breast cancer cases were analyzed. 17.5% of our patients had a history of immigration, including <i>n</i> = 202 first-generation immigrants and <i>n</i> = 168 second-generation immigrants. Most of them were citizens of EU27 member states. No significant difference was seen in age, tumor stage, histology, grading, Ki-67, Her2/neu-status, and hormone receptor status compared to the native cohort. 100% participation rate in the breast cancer early detection programs were seen in patients with no school graduation. With regards to the national mammography screening program, participation decreased significantly with educational status (<i>p</i> = 0.0003). <b><i>Conclusions:</i></b> No tumor biological differences were seen between immigrants and German natives. In first-generation immigrants, early detection programs were well accepted despite sociocultural and language differences. Participation rate decreased significantly with higher education levels irrespective of country of origin. Immigration background does not have a negative effect on the participation in breast cancer screening. This mainly relates to immigrants from EU27 member states.

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