scholarly journals Comparison of Grading and ER, PR Hormone Receptor Status of Carcinoma Breast in FNAC with Histopathology - A Cross Sectional Study from Thrissur, Kerala

2021 ◽  
Vol 8 (21) ◽  
pp. 1696-1700
Author(s):  
Suma Madathiveetil ◽  
Jisha Kalathil Thodiyil ◽  
Freena Rose
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Cross Sectional Study ◽  
Hormone Receptor Status ◽  
Sectional Study ◽  
Cross Sectional ◽  
Carcinoma Breast ◽  
Receptor Status ◽  
Common Cancer ◽  
Number Of Patients

BACKGROUND Breast cancer is now the most common cancer in cities in India and 2 nd most common cancer in the rural areas. Fine needle aspiration cytology (FNAC) is a less invasive pre-operative diagnostic method and is preferred over core / excision biopsy to decide the benign or malignant nature of the breast lump. Prognostic factor assessment by FNAC would allow the identification of patients who would benefit from neo adjuvant treatment (patients with grade 3 tumours) and in whom conservation surgery is inadvisable.1 The purpose of this study is to compare the grades of breast cancer in FNAC with histopathology as gold standard and compare the oestrogen (ER) and progesterone (PR) hormonal expression pattern on immunocytochemistry (ICC) with immunohistochemistry (IHC). From this study we intend to assess the usefulness of cytological grading and ER, PR hormone receptor status pre-operatively so that hormonal therapy can be included with neoadjuvant chemotherapy. METHODS This is a cross sectional study with a sample size of 50, conducted in the Department of Pathology. RESULTS Out of 50 cases, maximum number of patients were in the age group of 51 - 60 years. 68 % had attained menopause; 69 % of patients had tumour size between 2 - 5 cm and 90 % of tumours were in the upper outer quadrant of breast. Considering hormonal expression, in case of ER there was a moderate agreement between ICC and IHC (κ = .428, P = 0.005) and no agreement was seen in case of PR (κ = .073, P = 0.625). Regarding the cytological grading, this study showed highest degree of concordance with grade II tumours with a sensitivity of 75.9 %. For Grade I it was 2.5 % and for grade III, it was 33.3 %. CONCLUSIONS Evaluation of hormonal status and nuclear grading is fairly reliable on cytology when performed on qualitatively superior FNAC material from the primary breast lesions. KEYWORDS Carcinoma Breast, FNAC, ER / PR, Immunocytochemistry, Immunohistochemistry, Cytological Nuclear Grading

scholarly journals Epidemiological and pathological characteristics of post-surgical cases of invasive breast cancer among ethnicities of Iran in 2018: A single center cross-sectional study

2020 ◽  
Vol 26 (1) ◽  
pp. 6-9
Author(s):  
Soheila Sayad ◽  
Seyyed Ahmadi ◽  
Reza Nekouian ◽  
Mahshid Panahi ◽  
Khatereh Anbari
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Invasive Breast Cancer ◽  
Triple Negative ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Single Center ◽  
Cross Sectional ◽  
Familial History ◽  
Number Of Patients

Background: Present study aimed to investigate immunohistochemical parameters in post-surgical cases of invasive breast cancer. Methods: In this single center cross-sectional study we investigated ethnicity, familial history, type of cancer, stage of cancer, lymph node positivity, bilateral involvement, metastasis and immunohistochemical parameters (estrogen and progesterone receptor, human epidermal growth factor receptor 2, as well as frequency of triple positive and triple negative patients merely based on immunohistochemical parameters). Results: Frequency of positive familial history was 27.42% (16.31-38.52%). Lymph node involvement was detected in 55.93% (43.26-68.60%) of the cases. Frequency of positive HER2 was 38.60% (25.96-51.23%). There were 17.54% (7.67-27.42%) of triple positive and 7.02% (0.39-13.65%) of triple negative cases. The most common stage at the time of diagnosis was stage 3 with 43.33% (30.79-55.87%) frequency. In Lur/Lak population higher frequency of positive HER2 cases was detected whereas in Mazani population frequency of positive HER2 cases was low (p=0.0291). Conclusions: These results could contribute to understanding of breast cancer patterns among different ethnicities. In order to draw clear conclusion future investigations have to be done in several health centers, for longer time periods and with larger number of patients.

scholarly journals Breast cancer molecular subtypes and receptor status among women at Potchefstroom Hospital: a cross-sectional study

2021 ◽  
Vol 38 ◽  
Author(s):  
Baudouin Kongolo Kakudji ◽  
Prince Kasongo Mwila ◽  
Johanita Riétte Burger ◽  
Jesslee Melinda du Plessis ◽  
Kanishka Naidu
Keyword(s):  
Breast Cancer ◽  
Molecular Subtypes ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Receptor Status

Receptor Characteristics of the Second Tumor in Synchronous versus Metachronous Breast Cancer

2008 ◽  
Vol 74 (8) ◽  
pp. 702-706 ◽  
Author(s):  
Hanadi Bu-Ali ◽  
Melhem Solh ◽  
Arthi Kapur ◽  
Vijay Mittal
Keyword(s):  
Breast Cancer ◽  
Hormone Receptor ◽  
Hormone Receptor Status ◽  
Second Primary ◽  
Histologic Subtype ◽  
Receptor Status ◽  
Number Of Patients ◽  
Metachronous Breast Cancer ◽  
Synchronous Breast Cancer ◽  
Second Tumor

Presently, there is no consensus on whether synchronous breast cancer has the same disease origin as the primary tumor, or if it is a completely independent second primary. This study explores this concept in both synchronous and metachronous breast cancer looking specifically at their receptor characteristics and level of differentiation. A retrospective chart analysis of 114 patients with synchronous or metachronous breast cancer treated at a single institution between January 1991 and March 2004 was done. Sixty-three per cent of the patients were diagnosed with metachronous breast cancer. Synchronous breast cancer was histologically more aggressive ( P < 0.05) with a significantly higher number of patients having poorly differentiated tumors, a greater number of metastases involving a larger number of organs ( P < 0.05), and lower average survival compared with the metachronous group ( P < 0.005). Both the first and second tumor in both groups were similar in hormone receptor status, histologic subtype, and grade. Synchronous breast cancer is more aggressive and has a poorer outcome than metachronous breast cancer. Concordance in hormone receptor status, grade, and histologic subtype between different tumors within the same patient suggests, but does not completely support, a monoclonal origin. Analysis applied here is crude and more specific methods of analysis such as DNA microarray would be required to infer such a conclusion.

scholarly journals Awareness about breast cancer among women aged 15 years and above in urban slums: a cross sectional study

2018 ◽  
Vol 5 (3) ◽  
pp. 929 ◽  
Author(s):  
Sushma Katkuri ◽  
Misha Gorantla
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Nipple Discharge ◽  
Urban Slum ◽  
Cross Sectional Study ◽  
Warning Sign ◽  
Sectional Study ◽  
Cross Sectional ◽  
Common Cancer ◽  
Study Participants

Background: Breast cancer is the second most common cancer overall and is the most common cancer in women worldwide, both in the developed and developing countries. There are about 1.38 million new cases and 458,000 deaths from breast cancer each year. The aims and objectives of the study were to determine the awareness about breast cancer among urban slum women.Methods: A community based cross–sectional study was conducted at urban slum Shahpur Nagar, Hyderabad. The study participants were above 15 years of age and the study was conducted for a period of one month. A total of 200 study participants were enrolled.Results: Only 35% of the study population was aware about the early danger signs and 66% were unaware. Those who were aware in that 46.3% were breast lump is the early warning sign of breast cancer, followed by 28% said breast abscess, 16% pain in breast, 9% painless lump and 1.4% said for nipple discharge. Regarding skin changes nobody was aware about it. Awareness about risk factors for breast cancer was very poor that is only 21% were knowing about the risk factors about breast cancer. Near about 54% said they are aware about breast cancer by clinical examination done by doctor, 35% said by self breast examination and 12% said by mammography.Conclusions: Intensified health education campaigns should be conducted in the community and they be made aware about breast cancer. 

scholarly journals Hormone Receptor Status in Breast Cancer and its Relation to Age and Other Prognostic Factors

2011 ◽  
Vol 5 ◽  
pp. BCBCR.S7199 ◽  
Author(s):  
Ali Pourzand ◽  
M. Bassir A. Fakhree ◽  
Shahryar Hashemzadeh ◽  
Monireh Halimi ◽  
Amir Daryani
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Progesterone Receptor ◽  
Hormone Receptor ◽  
Hormone Receptor Status ◽  
Progesterone Receptor Status ◽  
Cross Sectional ◽  
P53 Expression ◽  
Receptor Status ◽  
Her 2

Background Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers. Patients and methods We organized an analytic cross-sectional study of 105 women diagnosed with breast cancer who have been operated on between 2008 to 2010. We evaluated age, size, hormone receptor status, HER-2 and P53 expression as possible indicator of lymph node involvement. Results There is a direct correlation between positive progesterone receptor status and being younger than 40 ( P < 0.05). Also, compared with older women, young women had tumors that were more likely to be large in size and have higher stages ( P < 0.05). Furthermore patients with negative progesterone receptor status were more likely to have HER-2 overexpression ( P < 0.05). The differences in propensity to lymph node metastasis between hormone receptor statuses were not statically significant. Conclusions Although negative progesterone receptor tumors were more likely to have HER-2 overexpression, it is possible that higher stage and larger size breast cancer in younger women is related to positive progesterone receptor status.

scholarly journals First Prospective Cross-Sectional Study on the Impact of Immigration Background and Education in Early Detection of Breast Cancer

Breast Care ◽  
2020 ◽  
pp. 1-7
Author(s):  
Elna Kuehnle ◽  
Wulf Siggelkow ◽  
Kristina Luebbe ◽  
Iris Schrader ◽  
Karl-Heinz Noeding ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
First Generation ◽  
Participation Rate ◽  
Educational Status ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
First Generation Immigrants ◽  
Cancer Early Detection

<b><i>Background:</i></b> Although immigrant health is an important issue in national health policy, there is a serious shortage of data in many countries. Most studies lack information on educational status, which is a major limitation. This prospective cross-sectional study analyzed a real-world breast cancer population on the influence of immigration background and educational status on participation in breast cancer early detection programs in the federal state of Lower Saxony, Germany. <b><i>Methods:</i></b> Data collection was conducted from 2012 to 2016 in six certified breast cancer centers using a standardized questionnaire for patients’ interview and tumor-specific data from the patients’ medical records. <b><i>Results:</i></b> 2,145/3,047 primary breast cancer cases were analyzed. 17.5% of our patients had a history of immigration, including <i>n</i> = 202 first-generation immigrants and <i>n</i> = 168 second-generation immigrants. Most of them were citizens of EU27 member states. No significant difference was seen in age, tumor stage, histology, grading, Ki-67, Her2/neu-status, and hormone receptor status compared to the native cohort. 100% participation rate in the breast cancer early detection programs were seen in patients with no school graduation. With regards to the national mammography screening program, participation decreased significantly with educational status (<i>p</i> = 0.0003). <b><i>Conclusions:</i></b> No tumor biological differences were seen between immigrants and German natives. In first-generation immigrants, early detection programs were well accepted despite sociocultural and language differences. Participation rate decreased significantly with higher education levels irrespective of country of origin. Immigration background does not have a negative effect on the participation in breast cancer screening. This mainly relates to immigrants from EU27 member states.

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