Abstract PR-08: Diabetes affects metabolism, redox signaling, DNA repair capacity and mutational burden in breast cancer

2022 ◽  
Author(s):  
Gatikrushna Panigrahi ◽  
Tiffany Dorsey ◽  
Wei Tang ◽  
Julian Candia ◽  
Amy Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Redox Signaling ◽  
Repair Capacity ◽  
Dna Repair Capacity ◽  
Mutational Burden

130 DNA repair capacity and irinotecan resistance in breast cancer cell lines

2015 ◽  
Vol 51 ◽  
pp. S9
Author(s):  
Z. Sztupinszki ◽  
B. Kalmár ◽  
B. Györffy
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Repair Capacity ◽  
Dna Repair Capacity

Abstract 1206:HER2/neu positivereceptor status is associated with a low DNA repair capacity in women with breast cancer

2011 ◽  
Author(s):  
Jaime L. Matta ◽  
Luisa Morales ◽  
Heidi Acosta ◽  
Wanda Vargas ◽  
Michelle Colon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Repair Capacity ◽  
Dna Repair Capacity

Removal of benzo(a)pyrene diol epoxide (BPDE)-DNA adducts as a measure of DNA repair capacity in lymphoblastoid cell lines from sisters discordant for breast cancer

2002 ◽  
Vol 40 (2) ◽  
pp. 93-100 ◽  
Author(s):  
Grazyna Motykiewicz ◽  
Beatrice Faraglia ◽  
Lian Wen Wang ◽  
Mary Beth Terry ◽  
Ruby T. Senie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Cell Lines ◽  
Dna Adducts ◽  
Lymphoblastoid Cell Lines ◽  
Repair Capacity ◽  
Dna Repair Capacity ◽  
Diol Epoxide

DNA repair capacity and acute radiotherapy adverse effects in Italian breast cancer patients

2010 ◽  
Vol 684 (1-2) ◽  
pp. 43-48 ◽  
Author(s):  
Silvia Sterpone ◽  
Tommaso Cornetta ◽  
Luca Padua ◽  
Valeria Mastellone ◽  
Daniela Giammarino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Adverse Effects ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Repair Capacity ◽  
Dna Repair Capacity

Abstract 3286: Correlation between vitamin D levels and DNA repair capacity in breast cancer patients stratified by molecular subtypes

2017 ◽  
Author(s):  
Carmen Ortiz ◽  
Jarline Encarnación ◽  
Ralphdy Vergne ◽  
Wanda Vargas ◽  
Jaime Matta
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Dna Repair ◽  
Cancer Patients ◽  
Molecular Subtypes ◽  
Breast Cancer Patients ◽  
Repair Capacity ◽  
Dna Repair Capacity ◽  
Vitamin D Levels

Polymorphisms in Nucleotide Excision Repair Genes and DNA Repair Capacity Phenotype in Sisters Discordant for Breast Cancer

2006 ◽  
Vol 15 (9) ◽  
pp. 1614-1619 ◽  
Author(s):  
Jing Shen ◽  
Manisha Desai ◽  
Meenakshi Agrawal ◽  
David O. Kennedy ◽  
Ruby T. Senie ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Repair Capacity ◽  
Dna Repair Capacity ◽  
Nucleotide Excision ◽  
Repair Genes

scholarly journals Circulating Vitamin D Levels and DNA Repair Capacity in Four Molecular Subtypes of Women with Breast Cancer

2020 ◽  
Vol 21 (18) ◽  
pp. 6880
Author(s):  
Carmen Ortiz-Sánchez ◽  
Jarline Encarnación-Medina ◽  
Ralphdy Vergne ◽  
Luis Padilla ◽  
Jaime Matta
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Dna Repair ◽  
Molecular Subtypes ◽  
Control Group ◽  
Repair Capacity ◽  
Positive Correlation ◽  
Dna Repair Capacity ◽  
Vitamin D Levels ◽  
Estrogen Synthesis

Vitamin D regulates estrogen synthesis among other mechanisms involved in breast cancer (BC) development; however, no evidence has been found regarding its relationship with DNA repair capacity (DRC). Therefore, the objective of this study was to elucidate whether DRC levels are linked with plasma 25(OH)D levels. BC cases and controls were selected from our BC cohort. DRC levels were assessed in lymphocytes through the host-cell reactivation assay. 25(OH)D levels were measured using the UniCel DxI 600 Access Immunoassay System. BC cases (n = 91) showed higher 25(OH)D levels than the controls (n = 92) (p = 0.001). When stratifying BC cases and controls into low and high DRC categories, BC cases with low DRC (n = 74) had the highest 25(OH)D levels (p = 0.0001). A positive correlation between 25(OH)D and DRC levels was found for the controls (r = 0.215, p = 0.043) while a negative correlation was found for BC cases (r = −0.236, p = 0.026). Significant differences in 25(OH)D levels were observed when stratifying by molecular subtypes (p = 0.0025). Our study provides evidence of a link between 25(OH)D and DRC in BC along with a description of to how 25(OH)D levels vary across subtypes. The positive correlation observed in the control group suggests that 25(OH)D contributes differently to DRC levels once the malignancy is developed.

scholarly journals Molecular contribution of BRCA1 and BRCA2 to genome instability in breast cancer patients: review of radiosensitivity assays

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Fatemeh Sadeghi ◽  
Marzieh Asgari ◽  
Mojdeh Matloubi ◽  
Maral Ranjbar ◽  
Nahid Karkhaneh Yousefi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Cycle ◽  
Dna Repair ◽  
Cancer Patients ◽  
Micronucleus Assay ◽  
Breast Cancer Patients ◽  
Brca1 And Brca2 ◽  
Repair Capacity ◽  
Dna Repair Capacity ◽  
History Of

Abstract Background DNA repair pathways, cell cycle arrest checkpoints, and cell death induction are present in cells to process DNA damage and prevent genomic instability caused by various extrinsic and intrinsic ionizing factors. Mutations in the genes involved in these pathways enhances the ionizing radiation sensitivity, reduces the individual’s capacity to repair DNA damages, and subsequently increases susceptibility to tumorigenesis. Body BRCA1 and BRCA2 are two highly penetrant genes involved in the inherited breast cancer and contribute to different DNA damage pathways and cell cycle and apoptosis cascades. Mutations in these genes have been associated with hypersensitivity and genetic instability as well as manifesting severe radiotherapy complications in breast cancer patients. The genomic instability and DNA repair capacity of breast cancer patients with BRCA1/2 mutations have been analyzed in different studies using a variety of assays, including micronucleus assay, comet assay, chromosomal assay, colony-forming assay, γ -H2AX and 53BP1 biomarkers, and fluorescence in situ hybridization. The majority of studies confirmed the enhanced spontaneous & radiation-induced radiosensitivity of breast cancer patients compared to healthy controls. Using G2 micronucleus assay and G2 chromosomal assay, most studies have reported the lymphocyte of healthy carriers with BRCA1 mutation are hypersensitive to invitro ionizing radiation compared to non-carriers without a history of breast cancer. However, it seems this approach is not likely to be useful to distinguish the BRCA carriers from non-carrier with familial history of breast cancer. Conclusion In overall, breast cancer patients are more radiosensitive compared to healthy control; however, inconsistent results exist about the ability of current radiosensitive techniques in screening BRCA1/2 carriers or those susceptible to radiotherapy complications. Therefore, developing further radiosensitivity assay is still warranted to evaluate the DNA repair capacity of individuals with BRCA1/2 mutations and serve as a predictive factor for increased risk of cancer mainly in the relatives of breast cancer patients. Moreover, it can provide more evidence about who is susceptible to manifest severe complication after radiotherapy.

scholarly journals Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity

2014 ◽  
Vol 32 (2) ◽  
pp. 505-512 ◽  
Author(s):  
RAFAEL GUERRERO-PRESTON ◽  
TAL HADAR ◽  
KIMBERLY LASKIE OSTROW ◽  
ETHAN SOUDRY ◽  
MIGUEL ECHENIQUE ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Family Member ◽  
Promoter Methylation ◽  
Repair Capacity ◽  
Dna Repair Capacity ◽  
Kinesin Family
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