Abstract ED01-01: Use of natural products as the scaffolds for the design of molecularly targeted agents for cancer treatment and prevention

Author(s):  
Shaomeng Wang
Author(s):  
Allan Michael Jordan

AbstractThe sequencing of tumour or blood samples is increasingly used to stratify patients into clinical trials of molecularly targeted agents, and this approach has frequently demonstrated clinical benefit for those who are deemed eligible. But what of those who have no clear and evident molecular driver? What of those deemed to have “nil actionable” mutations? How might we deliver better therapeutic opportunities for those left behind in the clamour toward stratified therapeutics? And what significant learnings lie hidden in the data we amass but do not interrogate and understand? This Perspective article suggests a holistic approach to the future treatment of such patients, and sets a framework through which significant additional patient benefit might be achieved. In order to deliver upon this framework, it encourages and invites the clinical community to engage more enthusiastically and share learnings with colleagues in the early drug discovery community, in order to deliver a step change in patient care.


2014 ◽  
Vol 10 (9) ◽  
pp. 1863-1893
Author(s):  
Harshad K. Shete ◽  
Swati S. Vyas ◽  
Vandana B. Patravale ◽  
John I. Disouza

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51039 ◽  
Author(s):  
Christophe Le Tourneau ◽  
Hui K. Gan ◽  
Albiruni R. A. Razak ◽  
Xavier Paoletti

2017 ◽  
Vol 18 (7) ◽  
pp. 1522 ◽  
Author(s):  
Alessia Bignucolo ◽  
Elena De Mattia ◽  
Erika Cecchin ◽  
Rossana Roncato ◽  
Giuseppe Toffoli

2015 ◽  
Vol 32 (8) ◽  
pp. 1170-1182 ◽  
Author(s):  
A. AlQathama ◽  
J. M. Prieto

Natural products continue to provide lead cytotoxic compounds for cancer treatment but less attention has been given to antimigratory compounds. We here systematically and critically survey more than 30 natural products with direct in vitro and in vivo pharmacological effects on migration and/or metastasis of melanoma cells and chart the mechanisms of action for this underexploited property.


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