Linked Suppression in Peripheral T Cell Tolerance to the House Dust Mite Derived Allergen Der p 1

1999 ◽  
Vol 118 (2-4) ◽  
pp. 122-124 ◽  
Author(s):  
Gerard F. Hoyne ◽  
Margaret J. Dallman ◽  
Jonathan R. Lamb
Blood ◽  
2001 ◽  
Vol 98 (4) ◽  
pp. 1135-1141 ◽  
Author(s):  
Hamida Hammad ◽  
Anne-Sophie Charbonnier ◽  
Catherine Duez ◽  
Alain Jacquet ◽  
Geoffrey A. Stewart ◽  
...  

The polarization of the immune response toward a Th2 or a Th1 profile can be mediated by dendritic cells (DCs) following antigen presentation and interaction with T cells. Costimulatory molecules such as CD80 and CD86 expressed by DCs, the polarizing cytokine environment during DC–T-cell interaction, and also the nature of the antigen are critical in the orientation of the immune response. In this study, the effect of the cysteine protease Der p 1, one of the major allergens of the house dust mite Dermatophagoides pteronyssinus, on these different parameters was evaluated comparatively on monocyte-derived DCs obtained from healthy donors, from pollen-sensitive patients, or from patients sensitive toDermatophagoides pteronyssinus. Results showed that Der p 1 induced an increase in CD86 expression only on DCs from house dust mite–sensitive patients. This was also associated with a higher capacity to induce T-cell proliferation, a rapid increase in the production of proinflammatory cytokines, tumor necrosis factor–α and interleukin (IL)-1β, and the type 2 cytokine IL-10. No changes in the release of IL-12 p70 were induced by Der p 1. Finally, purified T cells from house dust mite–sensitive patients stimulated by autologous Der p 1–pulsed DCs preferentially produced IL-4 rather than interferon-γ. These effects were abolished in the presence of the inactive precursor of Der p 1 (ProDer p 1). Taken together, these data suggest that DCs from house dust mite–sensitive patients, in contrast to DCs from healthy donors and from pollen-sensitive patients, exposed to Der p 1 play a pivotal role in the enhancement of the Th2 response associated with the allergic reaction developed in response to house dust mite exposure.


Allergy ◽  
2019 ◽  
Vol 74 (5) ◽  
pp. 976-985 ◽  
Author(s):  
Tadech Boonpiyathad ◽  
Milena Sokolowska ◽  
Hideaki Morita ◽  
Beate Rückert ◽  
Jeannette I. Kast ◽  
...  

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