Maternal Serum Levels of Human Chorionic Somatotropin Correlates with Transferrin and Erythropoietin in Pregnancy

Melatonin is a neuroendocrine hormone which regulates circadian rhythm and is also an antioxidant. The role of melatonin in pregnancy is emerging. The enzymes needed for endogenous synthesis of melatonin have been identified in the placenta, although the contribution to circulating maternal melatonin in normal pregnancy is unclear. This work aimed to determine serum levels of melatonin and its major metabolite 6-hydroxymelatonin sulfate (6-OHMS) in normal pregnant women during each trimester of pregnancy, and immediately after delivery. Blood samples were obtained from a cohort of healthy pregnant women during each trimester of pregnancy (n = 26), from women scheduled for elective Cesarean section (CS) before and after delivery (n = 15), along with placental samples, and from healthy non-pregnant women as controls (n = 30). Melatonin and its major metabolite, 6-OHMS, were measured using enzyme immunoassay. Levels of serum melatonin were significantly higher during pregnancy than in non-pregnant women (P = 0.025) and increased throughout pregnancy (P < 0.0001). In women undergoing CS, serum melatonin decreased markedly 24 h after delivery (P = 0.0013). Similar results were seen for serum levels of 6-OHMS, and placental tissue 6-OHMS levels correlated with week of gestation at delivery (p = 0.018). In summary, maternal melatonin production is higher in pregnant than in non-pregnant women, increases significantly during pregnancy with highest levels in the third trimester, and decreases abruptly after delivery. These results suggest that the placenta is a major source of melatonin and supports a physiological role for melatonin in pregnancy.

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PERBEDAAN RERATA KADAR AKTIVIN A SERUM MATERNAL ANTARA PREEKLAMSIA BERAT DENGAN BUKAN PREEKLAMSIA BERAT

JOURNAL OBGIN EMAS ◽

10.25077/aoj.1.1.30-37.2017 ◽

2019 ◽

Vol 1 (1) ◽

pp. 30-37

Author(s):

Dovy Djanas ◽

Bayu Pramudyo Ariwibowo ◽

Hafni Bachtiar

Keyword(s):

Serum Levels ◽

Activin A ◽

Maternal Serum ◽

Severe Preeclampsia ◽

Inclusion Criteria ◽

Exclusion Criteria ◽

Cross Sectional ◽

Tnf Α ◽

The Mean ◽

In Pregnancy

At the start of preelampsia there is a failure of cytotrophoblst invasion into the maternal spiral arteries that will lead to decreased uteroplacetal perfusion which will be followed by the failure of the unit fetoplacenter to get enough oxygen from the room intervillous that ultimately lead to a state of hypoxia in placenta. This will cause the expenditure of TNF-α dan IL-1β from placenta and a factors called hypoxia-inducible transcription factors that will spur the trophoblast to produce activin A lot more. This research was conducted by cross sectional method in maternal room of obstetrics and gynecology department of Central General Hospital of Dr. M. Djamil Padang from August 2015 until February 2016 with 20 patients of severe preeclampsia and 20 patients not severe preeclampsia, who met inclusion criteria and there is no exclusion criteria. Then performed statistical analysis using Mann-Whitney test to determine difference in mean maternal activin A serum levels of severe preeclampsia and not severe preeclampsia. The mean maternal serum levels of activin A in severe preeclampsia is 32,55 ± 1,84 ng/ml and in pregnancy with no severe preeclampsia is 8,59 ± 0,59 ng/ ml. Difference in mean maternal serum level of activin A in the two groups was statistically significant (p=0,001). Ma-ternal serum activin A levels is significantly higher in severe preeclampsia than pregnancy with no severe preeclampsia.Keywords: Activin A, severe preeclampsia, not severe preeclampsia

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Placental DNA methylation at term reflects maternal serum levels of INHA and FN1, but not PAPPA, early in pregnancy

BMC Medical Genetics ◽

10.1186/s12881-015-0257-z ◽

2015 ◽

Vol 16 (1) ◽

Cited By ~ 13

Author(s):

Samantha L. Wilson ◽

John D. Blair ◽

Kirsten Hogg ◽

Sylvie Langlois ◽

Peter von Dadelszen ◽

...

Keyword(s):

Dna Methylation ◽

Serum Levels ◽

Maternal Serum ◽

In Pregnancy

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Maternal serum levels of macrophage colony stimulating factor are related to adverse pregnancy outcome

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)86461-1 ◽

1998 ◽

Vol 5 (1) ◽

pp. 132A-132A

Author(s):

J KEITHJR ◽

R PIJNENBORG ◽

C LUVTEN ◽

B SPITZ ◽

R SCHAUB ◽

...

Keyword(s):

Pregnancy Outcome ◽

Adverse Pregnancy Outcome ◽

Serum Levels ◽

Maternal Serum ◽

Colony Stimulating Factor ◽

Macrophage Colony Stimulating Factor ◽

Adverse Pregnancy ◽

Macrophage Colony ◽

Stimulating Factor

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Interleukin-6 and Malondialdehyde in Women with Preterm Birth

Current Immunology Reviews ◽

10.2174/1573395515666191026140006 ◽

2019 ◽

Vol 15 (2) ◽

pp. 207-212

Author(s):

Vinita Verma ◽

Hina Oza ◽

Riddhi Thaker ◽

Sunil Kumar

Keyword(s):

Oxidative Stress ◽

Preterm Birth ◽

Interleukin 6 ◽

Critical Role ◽

Serum Levels ◽

Maternal Serum ◽

Full Term ◽

Mortality And Morbidity ◽

Term Birth ◽

Weak Negative Correlation

Background: Preterm Birth (PTB) is one of the main causes of neonatal death and infant mortality and morbidity. The pro-inflammatory cytokine interleukin-6 (IL-6) is a major proinflammatory mediator of the host response to infection and malondialdehyde (MDA) is a marker of oxidative stress. Objective : To evaluate potential associations between IL-6 and MDA levels in women with preterm birth. Method: A total of 150 women (66 with full-term and 84 with PTB) were enrolled in this case-control study. Predesigned performas were filled through questionnaire interviews to collect data on personal, demographic, occupational, lifestyle and reproductive history. Blood samples were collected within 36 hours of delivery. Serum concentrations of IL-6 and MDA were determined in mothers with full-term and preterm birth. Results: The mean age was marginally higher; whereas BMI was slightly lower in cases (PTB) as compared to controls (full-term) subjects. Serum IL-6 and MDA levels were significantly higher in subjects with PTB than full-term birth. The data were further analyzed with respect to underweight, normal and overweight/obese BMI. In all the BMI categories, the levels of IL-6 and MDA were higher in PTB cases. Among the PTB categories, the levels of IL-6 and MDA were highest in moderate to late preterm birth. A significant positive correlation was found between IL-6 and MDA levels. There was a weak negative correlation between either IL-6 or MDA and the number of gestational weeks. Conclusion : Elevated maternal serum levels of Interleukin-6 and Malondialdehyde in preterm as compared to full-term birth might suggest that inflammation and oxidative stress play a critical role in PTB.

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Resistin in pregnancy: analysis of determinants in pairs of umbilical cord blood and maternal serum

Cytokine X ◽

10.1016/j.cytox.2021.100052 ◽

2021 ◽

pp. 100052

Author(s):

Anne FLOECK ◽

Nina FERRARI ◽

Christine JOISTEN ◽

Maria T. PUTH ◽

Brigitte STRIZEK ◽

...

Keyword(s):

Cord Blood ◽

Umbilical Cord ◽

Umbilical Cord Blood ◽

Maternal Serum ◽

In Pregnancy

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Maternal Serum Placental Growth Factor, Soluble Fms-Like Tyrosine Kinase-1, and Soluble Endoglin in Twin Gestations and the Risk of Preeclampsia—A Systematic Review

Journal of Clinical Medicine ◽

10.3390/jcm9010183 ◽

2020 ◽

Vol 9 (1) ◽

pp. 183 ◽

Cited By ~ 1

Author(s):

Katarzyna Kosinska-Kaczynska ◽

Magdalena Zgliczynska ◽

Szymon Kozlowski ◽

Lukasz Wicherek

Keyword(s):

Growth Factor ◽

Tyrosine Kinase ◽

Serum Levels ◽

Maternal Serum ◽

Placental Growth Factor ◽

Cochrane Library ◽

Original Research ◽

Multiple Gestation ◽

Soluble Endoglin ◽

Twin Pregnancies

Multiple gestation is one of the key risk factors for the occurrence of preeclampsia (PE). Soluble fms-like tyrosine kinase-1, placental growth factor, and soluble endoglin are molecules involved in the process of angiogenesis with a proven role in the pathogenesis of PE. The aim of the review was to summarize available data on maternal serum levels of the above-mentioned factors and their usefulness in predicting PE in twin pregnancies. Only original research articles written in English were considered eligible. Reviews, chapters, case studies, conference papers, experts’ opinions, editorials, and letters were excluded from the analysis. No publication date limitations were imposed. The systematic literature search using PubMed/MEDLINE, Scopus, Embase, and Cochrane Library databases identified 338 articles, 10 of which were included in the final qualitative analyses. The included studies showed significant differences in maternal serum levels of the discussed factors between women with twin pregnancies with PE and those who did not develop PE, and their promising performance in predicting PE, alone or in combination with other factors. The identification of the most effective algorithms, their prompt introduction to the clinical practice, and further assessment of the real-life performance should become a priority.

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