Perceived Difficult Temperament, Hostile Maternal Child-Rearing Attitudes and Insulin Resistance Syndrome Precursors among Children: A 3-Year Follow-Up Study

Attention needs to be drawn to an important study of adopted children published recently by Bohman. In this 10- to 11-year follow-up study of children placed for adoption before 2 years of age by the Stockholm Adoption Agency in the mid 1950s, the health, school performance, school behavior, and school adjustment of 168 adopted children were compared to those of an appropriate set of control children. The importance of genetic, prenatal, and perinatal factors for the child's development were investigated as well as the adoptive parent's backgrounds, education, attitudes on child rearing, and socioeconomic status.

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Hyperinsulinemia and Homeostasis Model Assessment of Insulin Resistance as Predictors of Hypertension: A 5-Year Follow-Up Study of Korean Sample

American Journal of Hypertension ◽

10.1038/ajh.2011.89 ◽

2011 ◽

Vol 24 (9) ◽

pp. 1041-1045 ◽

Cited By ~ 21

Author(s):

K. C. Sung ◽

S. Lim ◽

R. S. Rosenson

Keyword(s):

Insulin Resistance ◽

Model Assessment ◽

Homeostasis Model Assessment ◽

Follow Up Study

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Plasma total adiponectin and changes in renal function in a cohort from the community: the prospective Data from an Epidemiological Study on the Insulin Resistance Syndrome study

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa228 ◽

2020 ◽

Author(s):

Frédéric Fumeron ◽

Ray El Boustany ◽

Jean-Philippe Bastard ◽

Soraya Fellahi ◽

Beverley Balkau ◽

...

Keyword(s):

Insulin Resistance ◽

Renal Function ◽

Diabetic Nephropathy ◽

Kidney Disease ◽

General Population ◽

Kidney Function ◽

Insulin Resistance Syndrome ◽

Plasma Adiponectin ◽

Kidney Function Decline

Abstract Background High adiponectin levels are associated with diabetic nephropathy. Nevertheless, it is not known whether plasma adiponectin is associated with renal function decline in the general population. We evaluated whether adiponectin concentrations were associated with changes in renal function in a community cohort, the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Methods Plasma adiponectin concentrations were measured in a random sample of 3284 people from the DESIR study, a 9-year prospective cohort from the general population. Data were analysed for three endpoints during follow-up: incidence of Stage 3 chronic kidney disease (CKD); the Kidney Disease: Improving Global Outcomes (KDIGO) criterion ‘certain drop in eGFR’ and rapid kidney function decline [estimated glomerular filtration rate (eGFR) slope steeper than −3 mL/min/1.73 m2/year]. Results After exclusion of participants with an eGFR <60 mL/min/1.73 m2 at baseline and those with type 2 diabetes or impaired fasting glycaemia at any time during follow-up (remaining n = 2174), there was a 113% higher risk for a rapid decline in kidney function in participants with adiponectin above the third tertile (T3) versus below the first tertile (T1) (Ptrend = 0.004) and a 53% higher risk for kidney function decline as defined by the KDIGO criterion (Ptrend = 0.04). In a cross-sectional analysis, adiponectin was positively associated with urinary albumin:creatinine ratio at baseline (P = 0.009). Conclusions In a healthy cohort from the general population, higher levels of plasma adiponectin were associated with decreased renal function at baseline and at follow-up. This result is similar to what is observed in people with diabetic nephropathy, in contrast with animal models of nephropathy.

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