Impaired Flow-Mediated Vasodilation in vivo and Reduced Shear-Induced Platelet Reactivity in vitro in Response to Nitric Oxide in Prothrombotic, Stroke-Prone Spontaneously Hypertensive Rats

Aortic strips removed from spontaneously hypertensive (SH) rats and preincubated with arachidonic acid (1.0 × 10−5 g/ml) for 15 min produced two times more prostaglandin (PG) like material than aortae unexposed to the precursor of PG biosynthesis. The stimulating effect of arachidonic acid was largely inhibited by indomethacin (1.0 × 10−5 g/ml). Also, the release of PG-like material by aortic strips derived from SH rats treated with an intravenous injection of indomethacin (10 mg/kg) was inhibited by 74% compared with the control tissues. These results raised the possibility that the in vivo conversion of arachidonic acid by large arteries of SH rats may contribute to the hypotensive effect of this PG precursor in SH rats.

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In vitro and in vivo release of brain dopamine in spontaneously hypertensive rats and normotensive wistar-kyoto rats: effect of quinpirole

European Journal of Pharmacology ◽

10.1016/0014-2999(90)92666-7 ◽

1990 ◽

Vol 183 (3) ◽

pp. 847 ◽

Cited By ~ 1

Author(s):

A.C.E. Linthorst ◽

H. De Lang ◽

W. De Jong ◽

D.H.G. Versteeg

Keyword(s):

Spontaneously Hypertensive Rats ◽

Hypertensive Rats ◽

Brain Dopamine ◽

Spontaneously Hypertensive ◽

Wistar Kyoto Rats ◽

In Vivo Release ◽

Wistar Kyoto

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Time-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats

International Journal of Hypertension ◽

10.1155/2014/859793 ◽

2014 ◽

Vol 2014 ◽

pp. 1-12 ◽

Cited By ~ 7

Author(s):

Odile Dumont ◽

Gilles Kauffenstein ◽

Anne-Laure Guihot ◽

Nathalie C. Guérineau ◽

Pierre Abraham ◽

...

Keyword(s):

Spontaneously Hypertensive Rats ◽

High Flow ◽

Low Flow ◽

Resistance Arteries ◽

Hypertensive Rats ◽

Spontaneously Hypertensive ◽

Wky Rats ◽

Cross Section Area

Hypertension is a major risk factor for cardiovascular disorders. As flow-mediated outward remodeling has a key role in postischemic revascularization, we investigated this remodeling in mesenteric resistance arteries of normotensive (WKY) and spontaneously hypertensive rats (SHRs) aged 3 to 9 months. Sequential ligation of mesenteric resistance arteries allowed modifying blood flowin vivo, thus exposing arteries to low, normal, or high flow. After 1, 3, 8, or 24 weeks, arteries were isolated forin vitrostudy. High flow (HF) induced outward hypertrophic remodeling in WKY rats after 1 week and persisted until 24 weeks without change in wall to lumen ratio. In SHRs, diameter increase was delayed, occurring only after 3 weeks. Nevertheless, it was reduced at 8 weeks and no longer significant after 24 weeks. In parallel, media cross-section area increased more with time in SHRs than in WKY rats and this was associated with increased contractility and oxidative stress with decreased NO-dependent relaxation. Low flow induced progressive inward remodeling until 24 weeks in both strains with excessive hypertrophy in SHRs. Thus, a chronic increase in flow induced transitory diameter expansion and long-lasting hypertrophy in SHRs. This could contribute to the higher susceptibility of hypertensive subjects to ischemic diseases.

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In Vitro and In Vivo Vascular Actions of Basic Fibroblast Growth Factor (bFGF) in Normotensive and Spontaneously Hypertensive Rats

Journal of Cardiovascular Pharmacology ◽

10.1097/00005344-199709000-00002 ◽

1997 ◽

Vol 30 (3) ◽

pp. 278-284 ◽

Cited By ~ 9

Author(s):

Deborah H. Damon ◽

Darrell L. Lange ◽

Brack G. Hattler

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Basic Fibroblast Growth Factor ◽

Spontaneously Hypertensive Rats ◽

Fibroblast Growth ◽

Hypertensive Rats ◽

Spontaneously Hypertensive

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Physical exercise decreases neuronal activity in the posterior hypothalamic area of spontaneously hypertensive rats

Journal of Applied Physiology ◽

10.1152/japplphysiol.00184.2004 ◽

2005 ◽

Vol 98 (2) ◽

pp. 572-578 ◽

Cited By ~ 22

Author(s):

Joseph A. Beatty ◽

Jeffery M. Kramer ◽

Edward D. Plowey ◽

Tony G. Waldrop

Keyword(s):

Physical Exercise ◽

Neuronal Activity ◽

Spontaneously Hypertensive Rats ◽

Hypertensive Rats ◽

Hypothalamic Area ◽

Spontaneously Hypertensive ◽

Firing Rates ◽

The Impact

Recently, physical exercise has been shown to significantly alter neurochemistry and neuronal function and to increase neurogenesis in discrete brain regions. Although we have documented that physical exercise leads to molecular changes in the posterior hypothalamic area (PHA), the impact on neuronal activity is unknown. The purpose of the present study was to determine whether neuronal activity in the PHA is altered by physical exercise. Spontaneously hypertensive rats (SHR) were allowed free access to running wheels for a period of 10 wk (exercised group) or no wheel access at all (nonexercised group). Single-unit extracellular recordings were made in anesthetized in vivo whole animal preparations or in vitro brain slice preparations. The spontaneous firing rates of PHA neurons in exercised SHR in vivo were significantly lower (8.5 ± 1.6 Hz, n = 31 neurons) compared with that of nonexercised SHR in vivo (13.7 ± 1.8 Hz, n = 38 neurons; P < 0.05). In addition, PHA neurons that possessed a cardiac-related rhythm in exercised SHR fired significantly lower (6.0 ± 1.8 Hz, n = 11 neurons) compared with nonexercised SHR (12.1 ± 2.4 Hz, n = 18 neurons; P < 0.05). Similarly, the spontaneous in vitro firing rates of PHA neurons from exercised SHR were significantly lower (3.5 ± 0.3 Hz, n = 67 neurons) compared with those of nonexercised SHR (5.6 ± 0.5 Hz, n = 58 neurons; P < 0.001). Both the in vivo and in vitro findings support the hypothesis that physical exercise can lower spontaneous activity of neurons in a cardiovascular regulatory region of the brain. Thus physical exercise may alter central neural control of cardiovascular function by inducing lasting changes in neuronal activity.

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Administration with Quinoa Protein Reduces the Blood Pressure in Spontaneously Hypertensive Rats and Modifies the Fecal Microbiota

Nutrients ◽

10.3390/nu13072446 ◽

2021 ◽

Vol 13 (7) ◽

pp. 2446

Author(s):

Huimin Guo ◽

Yuqiong Hao ◽

Xin Fan ◽

Aurore Richel ◽

Nadia Everaert ◽

...

Keyword(s):

Blood Pressure ◽

Spontaneously Hypertensive Rats ◽

Alpha Diversity ◽

Treated Group ◽

Fecal Microbiota ◽

Potential Candidate ◽

Hypertensive Rats ◽

Spontaneously Hypertensive

Despite the well-established role of quinoa protein as the source of antihypertensive peptides through in vitro enzymolysis, there is little evidence supporting the in vivo antihypertensive effect of intact quinoa protein. In this study, in vivo study on spontaneously hypertensive rats (SHRs) was conducted by administering quinoa protein for five weeks. Gastrointestinal content identification indicated that many promising precursors of bioactive peptides were released from quinoa protein under gastrointestinal processing. Quinoa protein administration on SHRs resulted in a significant decrease in blood pressure, a significant increase in alpha diversity, and microbial structure alternation towards that in non-hypertension rats. Furthermore, blood pressure was highly negatively correlated with the elevated abundance of genera in quinoa protein-treated SHRs, such as Turicibacter and Allobaculum. Interestingly, the fecal microbiota in quinoa protein-treated SHRs shared more features in the composition of genera with non-hypertension rats than that of the captopril-treated group. These results indicate that quinoa protein may serve as a potential candidate to lower blood pressure and ameliorate hypertension-related gut dysbiosis.

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