Pharmacotherapy for Nausea and Vomiting in Early Pregnancy

2003 ◽  
pp. 192-203
Author(s):  
N. Kemal Kuscu
Keyword(s):  
Early Pregnancy ◽  
Nausea And Vomiting

Nausea and vomiting of early pregnancy and pregnancy outcome. An epidemiological study

1989 ◽  
Vol 96 (11) ◽  
pp. 1304-1311 ◽  
Author(s):  
M. MARGARET WEIGEL ◽  
RONALD M. WEIGEL
Keyword(s):  
Pregnancy Outcome ◽  
Epidemiological Study ◽  
Early Pregnancy ◽  
Nausea And Vomiting

scholarly journals The effect of a pharmacist consultation on pregnant women’s quality of life with a special focus on nausea and vomiting: an intervention study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Maria Bich-Thuy Truong ◽  
Elin Ngo ◽  
Hilde Ariansen ◽  
Ross T. Tsuyuki ◽  
Hedvig Nordeng
Keyword(s):  
Quality Of Life ◽  
Early Pregnancy ◽  
Standard Care ◽  
Intervention Study ◽  
Intervention Group ◽  
Nausea And Vomiting ◽  
Quality Of Life Scale ◽  
The Impact ◽  
In Pregnancy

Abstract Background Maternal wellbeing and quality of life (QOL) are increasingly being recognized as important for healthy pregnancies. The aim of this study was to investigate the impact of a pharmacist consultation on pregnant women’s QOL focusing on nausea and vomiting in pregnancy (NVP), and patient satisfaction. Methods For this intervention study in 14 community pharmacies, women in early pregnancy were recruited and assigned to a pharmacist consultation (intervention) or standard care (control). The consultation aimed to address each woman’s concerns regarding medications and pregnancy-related ailments. Data were collected through online questionnaires at baseline (Q1) and during the second trimester (Q2). The intervention group completed an additional satisfaction questionnaire after the consultation was completed. The primary outcome was the impact of the intervention on the Quality of Life Scale (QOLS) scores between the first and second trimesters. The impact of the intervention was assessed by linear regression, and secondary analyses were performed to assess effect modification by NVP. Results Of the 340 women enrolled in the study, we analyzed data for 245. Half (170/340) of the original participants were allocated to the intervention group, of whom 131 received the pharmacist consultation. Most women (75%, 78/96) reported that the consultation was useful to a large/very large extent. The consultation had no overall impact on QOLS scores between the first and the second trimesters compared with standard care (adjusted β: 0.7, 95% CI: -2.1, 3.4). The impact of the intervention on QOLS was greater amongst women with moderate/severe NVP (adjusted β: 3.6, 95% CI: -0.6, 7.7) compared to those with no/mild NVP (adjusted β: -1.4, 95% CI: -5.1, 2.2) (interaction term study group*NVP severity, p = 0.048). Conclusions The pregnant women highly appreciated the pharmacist consultation, but the intervention did not affect their QOL scores compared with standard care. Future studies should further explore the effect of a pharmacist consultation specifically for NVP and on other outcomes such as use of health care services and medication use in pregnancy. Trial registration Retrospectively registered in ClinicalTrials.gov (identifier: NCT04182750, registration date: December 2, 2019).

Pregnancy Sickness

Physiology ◽  
1990 ◽  
Vol 5 (1) ◽  
pp. 5-10 ◽  
Author(s):  
P Andrews ◽  
S Whitehead
Keyword(s):  
Early Pregnancy ◽  
First Trimester ◽  
Nausea And Vomiting ◽  
Current Understanding ◽  
Physiological Changes ◽  
Inappropriate Response ◽  
First Trimester Of Pregnancy

The majority of women suffer from nausea and vomiting in the first trimester of pregnancy, but the mechanisms and reasons for this are unknown. Based on our current understanding of the emetic response and physiological changes of early pregnancy, hypotheses are put forward to explain this apparently inappropriate response to conception.

Evidence‐Based Approaches to Managing Nausea and Vomiting in Early Pregnancy

2009 ◽  
Vol 54 (6) ◽  
pp. 430-444 ◽  
Author(s):  
Tekoa L. King ◽  
Patricia Aikins Murphy
Keyword(s):  
Early Pregnancy ◽  
Nausea And Vomiting ◽  
Evidence Based

Interventions for nausea and vomiting in early pregnancy

2010 ◽  
Author(s):  
David Jewell ◽  
Gavin Young
Keyword(s):  
Early Pregnancy ◽  
Nausea And Vomiting

scholarly journals A study to identify clinical and laboratory parameters in cases of excessive vomiting in early pregnancy

2021 ◽  
Vol 10 (12) ◽  
pp. 4424
Author(s):  
Dyuti Dubey ◽  
Usha Agrawal ◽  
Rekha Sapkal
Keyword(s):  
Early Pregnancy ◽  
Hyperemesis Gravidarum ◽  
Serum Alkaline Phosphatase ◽  
Clinical Problem ◽  
First Trimester ◽  
Nausea And Vomiting ◽  
Severe Nausea ◽  
Laboratory Parameters ◽  
Study Population ◽  
Clinical Conditions

Background: Around half of all pregnant women experience vomiting, and more than 80% of women experience nausea in the first 12 weeks. Women with severe nausea and vomiting during pregnancy may have hyperemesis gravidarum (HG), an entity distinct from nausea and vomiting of pregnancy (NVP), which if left untreated may lead to significant maternal and foetal morbidity. In our study, we studied, clinical and laboratory parameters in patients presenting with excessive vomiting. The study may help in evaluating what is the major clinical problem encountered during treatment and how many days of care are needed in such cases.Methods: The study design was a prospective observational study. Patients attending the ANC clinic and emergency indoor cases at Peoples college of medical sciences, Bhopal were considered as study population. 100 patients who satisfied inclusion and exclusion criteria were included in the study. Patient’s sociodemographic variables, detailed obstetric history, clinical and laboratory parameters were recorded. Results obtained were analysed and tabulated.Results: Persistence of vomiting in the first trimester leading to dehydration and hospitalization was documented in 12% of patients. The 5% of then had metabolic acidosis and 1% required correction of starvation ketoacidosis, but there was not significant weight loss observed in any of the case. Liver function test were normal in almost in all cases except 9% had raised serum alkaline phosphatase levels.Conclusions: All cases with vomiting in early pregnancy should receive attention and exclusion of all emergency clinical conditions. Patient should be screened for urine tract infection and diabetes in all cases. 

scholarly journals OBSTETRIC AND PSYCHOLOGICAL CARE FOR PREGNANT WOMAN WITH HYPEREMESIS GRAVIDARUM WITH MODERATE ANXIETY

2021 ◽  
Vol 2 (2) ◽  
pp. 11-13
Author(s):  
Hesti Yuniastutiningsih ◽  
Dini Nafi'ati
Keyword(s):  
Pregnant Women ◽  
Early Pregnancy ◽  
Randomized Clinical Trials ◽  
Hyperemesis Gravidarum ◽  
Meta Analysis ◽  
Nausea And Vomiting ◽  
Hormonal Changes ◽  
Research Subjects ◽  
Midwifery Care ◽  
Human Research Subjects

Physical and psychological changes experienced by pregnant women, especially hormonal changes, cause symptoms of nausea and vomiting in early pregnancy. Excessive nausea and vomiting in early pregnancy and persist throughout pregnancy will cause physical and psychological complications. The existence of psychological problems in pregnant women can predispose to nausea and vomiting which then worsens. Emotional problems are also associated with the incidence of nausea and vomiting becoming more severe. Methods: the authors conducted extensive searches by scientific journals through trusted and frequently used databases, namely PubMed, Springer, and Science Direct. The keywords used were "hyperemesis" AND "psychological" with journal publication filters, the last 4 years, randomized clinical trials, systematic reviews, meta-analysis, human research subjects. Conclusion: care that focuses on mothers by applying the principles of holistic care, where patients not only receive midwifery care physically and biologically but include psychological, social, spiritual and cultural by involving their husbands in midwifery care is proven to accelerate the physical and psychological recovery of hyperemesis sufferers.

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