scholarly journals A study to identify clinical and laboratory parameters in cases of excessive vomiting in early pregnancy

2021 ◽  
Vol 10 (12) ◽  
pp. 4424
Author(s):  
Dyuti Dubey ◽  
Usha Agrawal ◽  
Rekha Sapkal
Keyword(s):  
Early Pregnancy ◽  
Hyperemesis Gravidarum ◽  
Serum Alkaline Phosphatase ◽  
Clinical Problem ◽  
First Trimester ◽  
Nausea And Vomiting ◽  
Severe Nausea ◽  
Laboratory Parameters ◽  
Study Population ◽  
Clinical Conditions

Background: Around half of all pregnant women experience vomiting, and more than 80% of women experience nausea in the first 12 weeks. Women with severe nausea and vomiting during pregnancy may have hyperemesis gravidarum (HG), an entity distinct from nausea and vomiting of pregnancy (NVP), which if left untreated may lead to significant maternal and foetal morbidity. In our study, we studied, clinical and laboratory parameters in patients presenting with excessive vomiting. The study may help in evaluating what is the major clinical problem encountered during treatment and how many days of care are needed in such cases.Methods: The study design was a prospective observational study. Patients attending the ANC clinic and emergency indoor cases at Peoples college of medical sciences, Bhopal were considered as study population. 100 patients who satisfied inclusion and exclusion criteria were included in the study. Patient’s sociodemographic variables, detailed obstetric history, clinical and laboratory parameters were recorded. Results obtained were analysed and tabulated.Results: Persistence of vomiting in the first trimester leading to dehydration and hospitalization was documented in 12% of patients. The 5% of then had metabolic acidosis and 1% required correction of starvation ketoacidosis, but there was not significant weight loss observed in any of the case. Liver function test were normal in almost in all cases except 9% had raised serum alkaline phosphatase levels.Conclusions: All cases with vomiting in early pregnancy should receive attention and exclusion of all emergency clinical conditions. Patient should be screened for urine tract infection and diabetes in all cases. 

scholarly journals PENGARUH AKUPRESUR PADA TITIK NEI GUAN, ZU SANLI DAN GONGSUN TERHADAP PENGURANGAN MUAL MUNTAH PADA IBU HAMIL TRIMESTER I DI PMB AFAH FAHMI A.Md. Keb SURABAYA

2018 ◽  
Vol 13 (3) ◽  
Author(s):  
Eka Meiri K, Noviana Kibas
Keyword(s):  
Pregnant Women ◽  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Nausea And Vomiting ◽  
Wilcoxon Test ◽  
P Value ◽  
Test Results ◽  
Severe Nausea ◽  
Purposive Sampling ◽  
Independent Variables

Keluhan yang dirasakan ibu hamil trimester I adalah mual muntah (emesis gravidarum). Mual dan muntah pada ibu hamil merupakan hal yang sering terjadi, terutama pada trimester I. Pada beberapa ibu hamil, mual dan muntah yang terjadi pada trimester I dapat berlanjut sampai masa kelahiran. Mual dan muntah yang berlangsung hebat, disebut dengan hiperemesis gravidarum, yang dapat membahayakan ibu dan fetus, karena sulitnya nutrisi untuk masuk. Tujuan penelitian ini adalah untuk mengetahui adakah pengaruh pemberian akupresur terhadap pengurangan mual muntah pada ibu hamil trimester I di BPM Afah Fahmi, Amd. Keb Surabaya.Teknik sampling dalam penelitian ini adalah Purposive sampling. Dengan menggunakan Rancangan penelitian One group pretest – Postest design. Populasi dalam penelitian ini adalah semua ibu hamil trimester I yang mengalami mual muntah sedangkan sampel penelitian sebanyak 15 responden. Instrumen yang digunakan adalah lembar observasi. Teknik yang digunakan untuk mengetahui pengaruh dari variabel dependen dan independen adalah uji Statistik Wilcoxon test.Hasil penelitian yang dilakukan di BPM Afah Fahmi, Amd.Keb Surabaya adalah ibu hamil trimester I yang mengalami mual muntah setelah diberikan akupresur terjadi penurunan mual muntah.  Dari hasil uji statistik Wilcoxon test di peroleh p-value 0,000 < α (0,05).Kesimpulan dalam penelitian ini adalah ada pengaruh pemberian akupresur terhadap pengurangan mual muntah pada ibu hamil trimester I di BPM Afah Fahmi, Amd Keb Surabaya. Oleh karena itu sebaiknya ibu hamil yang mengalami mual muntah dianjurkan untuk melakukan akupresur pada tenaga kesehatan yang profesional karena lebih mudah dan efektif. Kata kunci : akupresur, mual, muntah, ibu hamil ABSTRACTThe complaints felt by the first trimester pregnant women are nausea vomiting (emesis gravidarum). Nausea and vomiting in pregnant women is a common occurrence, especially in the trimester I. In some pregnant women, nausea and vomiting that occur in the trimester I may continue until delivery. Severe nausea and vomiting, called hyperemesis gravidarum, can be harmful to the mother and fetus, because of the difficult nutrients to enter. The purpose of this study was to determine whether there is an effect of acupressure on reducing nausea of vomiting in trimester pregnant women at BPM Afah Fahmi, Amd. Keb Surabaya.Sampling technique in this research is Purposive sampling. Using One group pretest - Postest design. The population in this study were all the trimester I pregnant women who experienced nausea vomiting while the study sample of 15 respondents. The instrument used is an observation sheet. The technique used to determine the effect of dependent and independent variables is the Wilcoxon Statistics test.The results of research conducted in BPM Afah Fahmi, Amd.Keb Surabaya is the trimester I pregnant women who experienced nausea vomiting after given acupressure decreased nausea vomiting. From Wilcoxon test results obtained p-value 0.000 <α (0.05).The conclusion in this research is there is effect of giving acupressure to the reduction of nausea vomiting in pregnant woman of trimester I at BPM Afah Fahmi, Amd Keb Surabaya. Therefore, pregnant women who experience nausea, vomiting is recommended to perform acupressure on health professionals because it is easier and more effective. Keywords: acupressure, nausea, vomiting, pregnant women

scholarly journals EFEKTIFITAS PEMBERIAN PERMEN JAHE TERHADAP MUAL MUNTAH PADA IBU HAMIL DI KLINIK KHAIRUNIDA SUNGGAL TAHUN 2018

2019 ◽  
Vol 1 (1) ◽  
pp. 36-44
Author(s):  
Ani Nurdiana ◽  
Betty Mangkuji ◽  
Rismahara Lubis
Keyword(s):  
Pregnant Women ◽  
Hyperemesis Gravidarum ◽  
Sampling Technique ◽  
First Trimester ◽  
Statistical Test ◽  
Nausea And Vomiting ◽  
P Value ◽  
Nutritional Disorder ◽  
Average Decrease ◽  
Pharmacy Department

Pregnancy causes a lot of change in the mother’s body, so there are various kinds of physiological discomfort in the mother such as nause and vomiting, usually mild and controlable. This condition sometimes stops in the first trimester, but its effect may lead to nutritional disorder, dehydration, weakness, weight loss, and electrolyte imbalances. If not treated, it will worsen into Hyperemesis Gravidarum This study aimed to determine the effectiveness og ginger candy in reducing the frecuency of nause and vomiting in first trimester pregnant women in the Khairunida clinik with experimental Quasy design and tested by One Group Pretest Postest. About 15 samples were obtained through purposive sampling technique and the data were taken using the T-dependent test. Through the study, it was found that the frequency of nausea and vomiting before being given intervation was 10,93 and after being given intervation was 3,33 with an average decrease by 7,60. Through the statistical test, it was obtained the p value <(0.05) so that this study concluded that administration of ginger candy was effective in reduring nausea and vomiting in first trimester pregnant women. Further researchers are expected toreduce the use of non-pharmacological drugs to overcome nausea and vomiting in first trimester pregnant women and collaborate with the pharmacy department to facilitate the process of making good qualityy ginger candy.

Pregnancy Sickness

Physiology ◽  
1990 ◽  
Vol 5 (1) ◽  
pp. 5-10 ◽  
Author(s):  
P Andrews ◽  
S Whitehead
Keyword(s):  
Early Pregnancy ◽  
First Trimester ◽  
Nausea And Vomiting ◽  
Current Understanding ◽  
Physiological Changes ◽  
Inappropriate Response ◽  
First Trimester Of Pregnancy

The majority of women suffer from nausea and vomiting in the first trimester of pregnancy, but the mechanisms and reasons for this are unknown. Based on our current understanding of the emetic response and physiological changes of early pregnancy, hypotheses are put forward to explain this apparently inappropriate response to conception.

scholarly journals Significantly Elevated Serum Lipase in Pregnancy with Nausea and Vomiting: Acute Pancreatitis or Hyperemesis Gravidarum?

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Amanda Johnson ◽  
Bethany Cluskey ◽  
Nina Hooshvar ◽  
Daphne Tice ◽  
Courtney Devin ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Biochemical Marker ◽  
Hyperemesis Gravidarum ◽  
Elevated Serum ◽  
Clinical Findings ◽  
Nausea And Vomiting ◽  
Imaging Studies ◽  
Severe Nausea ◽  
Serum Lipase ◽  
Severe Manifestation

Hyperemesis gravidarum is a severe manifestation of nausea and vomiting of pregnancy and it is associated with weight loss and metabolic abnormalities. It is known that abnormal laboratory values, including mildly elevated serum lipase level, could be associated with hyperemesis gravidarum. However, in this case report details of two women with hyperemesis gravidarum but with significantly elevated serum lipase levels were discussed. These patients presented with severe nausea and vomiting but without abdominal pain. They were found to have severely elevated lipase levels over 1,000 units/liter. In the absence of other findings of pancreatitis, they were treated with conservative measures for hyperemesis gravidarum, with eventual resolution to normal lipase levels. Although significantly elevated lipase level in pregnant patients with nausea and vomiting is a concern for acute pancreatitis, these two cases of significantly elevated serum lipase without other clinical findings of pancreatitis led to this report that serum lipase could be quite elevated in hyperemesis gravidarum and that it might not be an accurate biochemical marker for acute pancreatitis. Imaging studies are thus necessary to establish the diagnosis of acute pancreatitis.

scholarly journals Gestational Thyrotoxicosis in a Patient With Hyperemesis Gravidarum

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A929-A929
Author(s):  
Hind Alameddine ◽  
Gurunanthan Palani ◽  
Kidmealem Zekarias
Keyword(s):  
Hyperemesis Gravidarum ◽  
Clinical Signs ◽  
Supportive Therapy ◽  
First Trimester ◽  
Nausea And Vomiting ◽  
Antithyroid Drugs ◽  
Significant Elevation ◽  
Free T4 ◽  
Overt Hyperthyroidism ◽  
In Pregnancy

Abstract Untreated or inadequately treated overt hyperthyroidism in pregnancy can have devastating consequences for both mother and fetus. At the same time antithyroid drugs (ATDs) are known for their teratogenic effect and should be avoid when possible; once the diagnosis of hyperthyroidism is made in a pregnant woman, attention should be focused on determining the etiology of the disorder and whether it warrants treatment. Here, we report a case of hyperemesis gravidarum patient presenting with significant elevation of thyroid hormones and a review on diagnosis and management of gestational transient thyrotoxicosis. A 33-year-old female, G4P3 at 8 weeks pregnant admitted for nausea and vomiting. Thyroid labs showed TSH &lt; 0.01 (Reference: 0.4-4.0mU/L) and free T4 is 3.53 (Reference: 0.76-1.46ng/dl). Patient was discharged on antiemetics with a diagnosis of hyperemesis gravidarum. She was re-admitted at 9 weeks pregnant with ongoing nausea and vomiting. She had palpitations, fatigue and reported 15 pound weight loss in 2 weeks. Past medical history included thyroid hormone abnormality noted during pregnancies of 2011 and 2017. Physical exam was significant for tachycardia and diffusely enlarged thyroid gland. Repeat labs showed TSH &lt;0.01, free T4 5.81, total T3 of 317 (Reference: 60-181ng/dl). Thyroid ultrasound showed multiple nodules. Considering significant elevation in free T4 and total T3; empiric therapy with propylthiouracil was recommended. Patient declined anti-thyroid therapy. TSI and TRH antibodies came back later as negative. Patient was treated with enteral feeding for hyperemesis gravidarum. Thyroid labs 3 weeks later improved; FT4 down to 1.63 and TT3 down to 250. Patient delivered healthy baby at 40 weeks of gestation. Although the differential diagnosis of thyrotoxicosis in pregnancy includes any cause that can be seen in a nonpregnant patient, the most likely causes for hyperthyroidism in pregnancy are gestational thyrotoxicosis (GTT) with or without hyperemesis gravidarum or Graves’ disease. GTT is described as an hCG-mediated hyperthyroidism that occurs in the first trimester of pregnancy; it is generally asymptomatic with mild biochemical hyperthyroidism. Distinguishing true overt hyperthyroidism from GTT in a setting of hyperemesis gravidarum is challenging. The absence of clinical signs of hyperthyroidism and negative thyroid antibodies supports the diagnosis of GTT. T3 tends to be disproportionately elevated more than T4 in patients with overt hyperthyroidism. HCG level has not been found to be useful in distinguishing between GTT and GD. Overt hyperthyroidism is treated using anti-thyroid drugs (ATD) whereas supportive therapy without ATD is the accepted standard of treatment of patients with hyperemesis gravidarum and GTT. More studies addressing the best management of these group of patients is needed.

scholarly journals OBSTETRIC AND PSYCHOLOGICAL CARE FOR PREGNANT WOMAN WITH HYPEREMESIS GRAVIDARUM WITH MODERATE ANXIETY

2021 ◽  
Vol 2 (2) ◽  
pp. 11-13
Author(s):  
Hesti Yuniastutiningsih ◽  
Dini Nafi'ati
Keyword(s):  
Pregnant Women ◽  
Early Pregnancy ◽  
Randomized Clinical Trials ◽  
Hyperemesis Gravidarum ◽  
Meta Analysis ◽  
Nausea And Vomiting ◽  
Hormonal Changes ◽  
Research Subjects ◽  
Midwifery Care ◽  
Human Research Subjects

Physical and psychological changes experienced by pregnant women, especially hormonal changes, cause symptoms of nausea and vomiting in early pregnancy. Excessive nausea and vomiting in early pregnancy and persist throughout pregnancy will cause physical and psychological complications. The existence of psychological problems in pregnant women can predispose to nausea and vomiting which then worsens. Emotional problems are also associated with the incidence of nausea and vomiting becoming more severe. Methods: the authors conducted extensive searches by scientific journals through trusted and frequently used databases, namely PubMed, Springer, and Science Direct. The keywords used were "hyperemesis" AND "psychological" with journal publication filters, the last 4 years, randomized clinical trials, systematic reviews, meta-analysis, human research subjects. Conclusion: care that focuses on mothers by applying the principles of holistic care, where patients not only receive midwifery care physically and biologically but include psychological, social, spiritual and cultural by involving their husbands in midwifery care is proven to accelerate the physical and psychological recovery of hyperemesis sufferers.

Association between severe nausea and vomiting in early pregnancy and the risk of neural tube defects in Northern China

2017 ◽  
Vol 110 (5) ◽  
pp. 406-412 ◽  
Author(s):  
Yali Zhang ◽  
Zhiwen Li ◽  
Le Zhang ◽  
Jufen Liu ◽  
Lei Jin ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Early Pregnancy ◽  
Northern China ◽  
Nausea And Vomiting ◽  
Severe Nausea

scholarly journals Efektivitas Pemberian Seduhan Jahe terhadap Frekuensi Emesis Gravidarum Trimester I

2020 ◽  
Vol 7 (1) ◽  
pp. 1
Author(s):  
Dewi Aprilia Ningsih ◽  
Metha Fahriani ◽  
Melly Azhari ◽  
Mika Oktarina
Keyword(s):  
Pregnant Women ◽  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Average Frequency ◽  
Nausea And Vomiting ◽  
Rank Test ◽  
P Value ◽  
Purposive Sampling ◽  
Post Test ◽  
Wilcoxon Sign Rank

ABSTRAKEmesis atau mual dan  muntah pada kehamilan merupakan hal yang fisiologis, namun apabila terjadi berkelanjutan menjadi hiperemesis gravidarum dapat meningkatkan resiko terjadinya gangguan pada kehamilan. Mual dan muntah selama masa kehamilan dapat diatasi dengan terapi non farmakologi salah satunya menggunakan seduhan jahe. Penelitian ini bertujuan untuk mengetahui efektivitas pemberian seduhan jahe terhadap frekuensi mual dan muntah pada ibu hamil timester I. Penelitian ini menggunakan desain quasi eksperimen dengan rancangan one group pretest-post test. Populasi dalam penelitian ini adalah ibu hamil trimester I yang mengalami mual dan muntah. Sampel diambil dengan teknik purposive sampling sebanyak 22 responden.  Analisis data menggunakan uji wilcoxon sign rank. Hasil penelitian didapatkan rata-rata frekuensi mual dan muntah sebelum dilakukan pemberian seduhan jahe sebesar 9,36 kali/hari, sedangkan rata-rata setelah dilakukan pemberian seduhan jahe sebesar 4,86 kali/hari. Terdapat perbedaan rata-rata frekuensi mual muntah sebelum dan sesudah intervensi seduhan jahe dengan nilai Z=-4,123 dan p value = 0,000 . Pemberian seduhan jahe efektif dalam mengurangi frekuensi mual dan muntah pada ibu hamil trimester I. Kata kunci : emesis gravidarum;  ibu hamil; seduhan jahe; mual dan muntah   THE EFFECTIVENESS OF STEEPING GINGER DRINK TO THE FREQUENCY OF GRAVIDARUM EMESISTS IN THE FIRST TRIMESTER PREGNANT WOMEN ABSTRACTNausea and vomiting in pregnancy is physiological symptom, but if it continues to be hyperemesis gravidarum it can increase the risk of pregnancy disorders. Nausea and vomiting during pregnancy can be overcome with non-pharmacological therapy, one of which uses ginger steeping. This study was aimed to determine the effectiveness of ginger steeping to the frequency of nausea and vomiting in the first trimester pregnant women. This study used a Quasi experimental design with a One Group Pretest-Post test design. Samples were taken by purposive sampling technique amounted to 22 respondents. Data analysis used the Wilcoxon Sign Rank test. The results showed an average frequency of nausea and vomiting before giving ginger was 9.36, while the average after giving ginger was 4.86. There is a difference in the average frequency of nausea and vomiting before and after the intervention of ginger steeping with Z value = -4,123 and p value = 0,000, which means that ginger steeping is effective in reducing the frequency of nausea and vomiting in first trimester pregnant women. . Keywords: emesis gravidarum;  pregnant women; steeping ginger; nausea and vomiting 

scholarly journals Pengaruh Pemberian Extrak Jahe Dan Kacang Hijau Terhadap Pengurangan Mual Pada Ibu Hamil Semester 1 Di Puskesmas Ngawen 2 Wonosari Gunung Kidul

2019 ◽  
Vol 4 (2) ◽  
pp. 95-101
Author(s):  
Sih Rini Handajani ◽  
KH Endah Widhi Astuti
Keyword(s):  
Time Series ◽  
Pregnant Women ◽  
Hyperemesis Gravidarum ◽  
First Trimester ◽  
Nausea And Vomiting ◽  
P Value ◽  
Test Results ◽  
Green Beans ◽  
First Trimester Of Pregnancy ◽  
Post Hoc

Background: Nausea and vomiting are common discomforts experienced by 50% of pregnant women.  Emesis gravidarum will gain weight into hyperemesis gravidarum.  Management to overcome the discomfort of nausea and vomiting in the first trimester of pregnancy is to use pharmacological and non-pharmacological therapies including ginger drink and green beans.  The purpose of this study was to determine the effect of ginger drink and green beans on the frequency of nausea and vomiting in trimester pregnant women. Methods: Used in this study was quasy experiment with a time series pretest-posttest design approach.  The population in this study was TM I pregnant women in the Ngawen II health center. The sample in this study was first trimester pregnant women who experienced nausea and vomiting. The analysis of this study used the Wilcoxon and Kruskal-wallis test. Results: Showed there was an effect of giving ginger drink and green beans to the frequency of nausea vomiting in first trimester pregnant women with p value 0.01 <α with ginger drink being the most influential in post hoc nausea frequency of vomiting 6.67 compared to green beans and standard drugs. Conclusion: Administration of ginger drink and green beans has an effect on reducing the frequency of nausea and vomiting in first trimester pregnant women.

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