Understanding the Role of CD4+CD25high (So-Called Regulatory) T Cells in Idiopathic Pulmonary Arterial Hypertension

Respiration ◽  
2008 ◽  
Vol 75 (3) ◽  
pp. 253-256 ◽  
Author(s):  
Frédéric Perros ◽  
Sylvia Cohen-Kaminsky ◽  
Marc Humbert
Keyword(s):  
T Cells ◽  
Pulmonary Arterial Hypertension ◽  
Regulatory T Cells ◽  
Arterial Hypertension ◽  
Idiopathic Pulmonary Arterial Hypertension ◽  
Pulmonary Arterial

scholarly journals The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

2019 ◽  
Vol 8 (23) ◽  
Author(s):  
Haihua Qiu ◽  
Yi He ◽  
Fan Ouyang ◽  
Ping Jiang ◽  
Shuhong Guo ◽  
...  
Keyword(s):  
T Cells ◽  
Pulmonary Arterial Hypertension ◽  
Regulatory T Cells ◽  
Arterial Hypertension ◽  
Pulmonary Arterial

scholarly journals The Role of Regulatory T Cells in Pulmonary Arterial Hypertension

2021 ◽  
Vol 12 ◽  
Author(s):  
Wen Tian ◽  
Shirley Y. Jiang ◽  
Xinguo Jiang ◽  
Rasa Tamosiuniene ◽  
Dongeon Kim ◽  
...  
Keyword(s):  
T Cells ◽  
Pulmonary Arterial Hypertension ◽  
Regulatory T Cells ◽  
Arterial Hypertension ◽  
Right Heart Failure ◽  
Strongly Correlated ◽  
Incurable Condition ◽  
Pulmonary Arterial ◽  
Inflammatory Milieu

Pulmonary arterial hypertension (PAH) is a chronic, incurable condition characterized by pulmonary vascular remodeling, perivascular inflammation, and right heart failure. Regulatory T cells (Tregs) stave off autoimmunity, and there is increasing evidence for their compromised activity in the inflammatory milieu of PAH. Abnormal Treg function is strongly correlated with a predisposition to PAH in animals and patients. Athymic Treg-depleted rats treated with SU5416, an agent causing pulmonary vascular injury, develop PAH, which is prevented by infusing missing CD4+CD25highFOXP3+ Tregs. Abnormal Treg activity may also explain why PAH disproportionately affects women more than men. This mini review focuses on the role of Tregs in PAH with a special view to sexual dimorphism and the future promise of Treg therapy.

The Role of Uric Acid in Pediatric Idiopathic Pulmonary Arterial Hypertension: Analysis From a 10-Year Registry

CHEST Journal ◽  
2010 ◽  
Vol 138 (4) ◽  
pp. 805A
Author(s):  
Jose G. Gomez-Arroyo ◽  
Juan P. Sandoval-Jones ◽  
Paulina Ramirez-Neria ◽  
Armando Rodriguez ◽  
Carla Murillo ◽  
...  
Keyword(s):  
Uric Acid ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Idiopathic Pulmonary Arterial Hypertension ◽  
Pulmonary Arterial

Alterations in circulating helper T-cells in idiopathic pulmonary arterial hypertension

2019 ◽  
Author(s):  
Denise van Uden ◽  
Menno Van Nimwegen ◽  
Thomas Koudstaal ◽  
Peter Heukels ◽  
Jennifer Van Hulst ◽  
...  
Keyword(s):  
T Cells ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Idiopathic Pulmonary Arterial Hypertension ◽  
Helper T Cells ◽  
Pulmonary Arterial

Role of vascular remodeling markers in the development of osteoporosis in idiopathic pulmonary arterial hypertension

2016 ◽  
Vol 88 (9) ◽  
pp. 65-70
Author(s):  
V A Nevzorova ◽  
E A Kochetkova ◽  
L G Ugay ◽  
Yu V Maistrovskaya ◽  
E A Khludeeva
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
High Risk ◽  
Cardiac Index ◽  
Arterial Hypertension ◽  
Healthy Volunteers ◽  
Vascular Remodeling ◽  
Serum Levels ◽  
Idiopathic Pulmonary Arterial Hypertension ◽  
Pulmonary Arterial

Aim. To define the role of circulating biomarkers for the metabolism of collagen and intercellular substance and vascular remodeling in the development of osteoporosis (OP) in idiopathic pulmonary arterial hypertension (IPAH). Materials and methods. Functional hemodynamic parameters, bone mineral density (BMD) in the lumbar spine and femoral neck and the serum levels of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), MMP-9/TIMP-1 complex, C-terminal telopeptide of collagen type 1 (CITP), and endothelin-1 (ET-1) were determined in 27 high-risk IPAH patients and 30 healthy volunteers. Results. OP in IPAH was detected in 50% of the examinees. The serum levels of CITP, MMP-9, TIMP-1, and ET-1 proved to be higher in the high-risk IPAH patients than in the healthy volunteers. There was a direct correlation between BMD and six-minute walk test and an inverse correlation with total pulmonary vascular resistance (TPVR). Serum TMIP-1 levels correlated with cardiac index and TPVR; ET-1 concentrations were directly related to pulmonary artery systolic pressure, cardiac index, and TPVR. Inverse relationships were found between BMD and circulating CITP, MMP-9, TMIP-1, MMP-9/TMIP-1, and ET-1. At the same time, there was only a tendency towards a positive correlation between serum CITP and ET-1 concentrations. Conclusion. The results of the investigation confirm that endothelin system dysregulation plays a leading role in the development of persistent hemodynamic disorders in high-risk IPAH and suggest that it is involved in the development of osteopenic syndrome. Enhanced ET-1 secretion initiates bone loss possibly via activation of connective tissue matrix destruction.

scholarly journals Overexpression of PD-1 on Peripheral Blood Lymphocytes in Patients with Idiopathic Pulmonary Arterial Hypertension and Its Association with High Viral Loads of Epstein-Barr Virus and Poor Clinical Parameters

2020 ◽  
Vol 9 (6) ◽  
pp. 1966 ◽  
Author(s):  
Michał Tomaszewski ◽  
Ewelina Grywalska ◽  
Andrzej Tomaszewski ◽  
Piotr Błaszczak ◽  
Marcin Kurzyna ◽  
...  
Keyword(s):  
T Cells ◽  
Immune System ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Epstein Barr Virus ◽  
Idiopathic Pulmonary Arterial Hypertension ◽  
Barr Virus ◽  
Ebv Infection ◽  
Pulmonary Arterial ◽  
Epstein Barr

Idiopathic pulmonary arterial hypertension (IPAH) is a rare but severe disease with the elevated blood pressure in the pulmonary arteries without a known trigger of vascular remodelling. It leads to the right heart failure with reduced survival. Changes in the immunological landscape of the lungs and the periphery are common in IPAH patients, suggesting an immune system dysfunction. A cohort of 25 IPAH patients was enrolled in our study to investigate a link between the patient’s clinical status, immune parameters of the blood, and the Epstein–Barr virus (EBV) infection. We found significant alterations of the patients’ peripheral blood parameters. Therein, T lymphocytes and NK cell counts were decreased in the IPAH patients’ blood, while the proportion of regulatory T cells was increased. Additionally, levels of proinflammatory cytokines interleukin-6 (IL-6), IL-2, and interferon-gamma (IFN-γ) were elevated. We identified a weak correlation between EBV loads and IPAH patients’ clinical state (r = 0.54) and between EBV loads and overexpression of PD-1 on helper T cells (r = 0.56). We speculate that a significant dysregulation of the immune system homeostasis observed in IPAH patients may contribute to increased susceptibility of those patients to EBV infection, yet further longitudinal studies are required to characterize this relation in detail.

scholarly journals Identification of Potential Risk Genes and the Immune Landscape of Idiopathic Pulmonary Arterial Hypertension via Microarray Gene Expression Dataset Reanalysis

Genes ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 125
Author(s):  
Jing Xu ◽  
Yicheng Yang ◽  
Yuejin Yang ◽  
Changming Xiong
Keyword(s):  
T Cells ◽  
Pulmonary Arterial Hypertension ◽  
Mast Cells ◽  
Arterial Hypertension ◽  
Signaling Pathway ◽  
Immune Cells ◽  
Molecular Targets ◽  
Idiopathic Pulmonary Arterial Hypertension ◽  
Cox Regression Analysis ◽  
Pulmonary Arterial

Gene dysfunction and immune cell infiltration play an essential role in the pathogenesis of idiopathic pulmonary arterial hypertension (IPAH). We aimed to investigate the immune landscape and novel differentially expressed genes (DEGs) of IPAH. In addition, potential druggable molecular targets for IPAH were also explored. In this study, the GSE117261 dataset was reanalyzed to explore the immune landscape and hub DEGs of IPAH. Lasso Cox regression analysis and receiver operating characteristic curve analysis were performed to detect the predictive value of IPAH. Additionally, the underlying drug targets for IPAH treatment were determined by drug–gene analysis. IPAH was significantly associated with the transforming growth factor-β (TGF-β) signaling pathway and Wnt signaling pathway as well as energetic metabolism dysfunction. We identified 31 upregulated and 39 downregulated DEGs in IPAH patients. Six hub genes, namely, SAA1, CCL5, CXCR1, CXCR2, CCR1, and ADORA3, were related to IPAH pathogenesis regardless of sex differences. Prediction model analysis showed that the area under the curve values of the hub DEGs except CXCR2 were all above 0.9 for distinguishing IPAH patients. In addition, the relative proportions of 5 subtypes of immune cells, namely, CD8+ T cells, CD4+ memory resting T cells, γ delta T cells, M1 macrophages, and resting mast cells, were significantly upregulated in the IPAH samples, while 6 subtypes of immune cells, namely, CD4+ naive T cells, resting NK cells, monocytes, M0 macrophages, activated mast cells, and neutrophils, were downregulated. Additionally, a total of 17 intersecting drugs targeting 5 genes, CCL5, CXCR1, CXCR2, CCR1, and ADORA3, were generated as potential druggable molecular targets for IPAH. Our study revealed the underlying correlations between genes and immune cells in IPAH and demonstrated for the first time that SAA1, CCL5, CXCR1, CCR1, and ADORA3 may be novel genetic targets for IPAH.

scholarly journals The role of nuclear factor of activated T cells in pulmonary arterial hypertension

Cell Cycle ◽  
2017 ◽  
Vol 16 (6) ◽  
pp. 508-514 ◽  
Author(s):  
Rui Chen ◽  
Jinchuan Yan ◽  
Peijing Liu ◽  
Zhongqun Wang ◽  
Cuiping Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Nuclear Factor ◽  
Activated T Cells ◽  
Pulmonary Arterial
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