Cordocentesis: Overall Pregnancy Loss Rate as Important as Procedure Loss Rate

Objective: The aim of the study was to prospectively gather data on pregnancy outcomes of prenatally diagnosed trisomy 21 (T21) in a large tertiary referral centre. Methods: Data were gathered prospectively in a large tertiary referral centre over 5 years from 2013 to 2017 inclusively. Baseline demographic and pregnancy outcome data were recorded on an anonymized computerized database. Results: There were 1,836 congenital anomalies diagnosed in the study period including 8.9% (n = 165) cases of T21. 79% (n = 131) were age 35 or older at diagnosis. 79/113 (69.9%) women chose a termination of pregnancy (TOP) following a diagnosis of T21. Amongst pregnancies that continued, there were 4 second-trimester miscarriages (4/34, 11.7%), 9 stillbirths (9/34, 26.4%), and 1 neonatal death, giving an overall pregnancy and neonatal loss rate of 14/34 (41.1%). Conclusion: The risk of foetal loss in prenatally diagnosed T21 is high at 38% with an overall pregnancy loss rate of 41.1%. This information may be of benefit when counselling couples who are faced with a diagnosis of T21 particularly in the context of limited access to TOP.

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The biochemical pregnancy loss rate remains stable up irrespective of age and differs in pattern from clinical miscarriages

Gynecological Endocrinology ◽

10.1080/09513590.2020.1807931 ◽

2020 ◽

Vol 37 (1) ◽

pp. 61-64 ◽

Cited By ~ 1

Author(s):

Michael H. Dahan ◽

Atif Zeadna ◽

Daniel Dahan ◽

Weon-Young Son ◽

Naama Steiner

Keyword(s):

Pregnancy Loss ◽

Loss Rate ◽

Biochemical Pregnancy

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Early clinical pregnancy loss rate in poor responder patients does not change compared to age-matched normoresponders

Fertility and Sterility ◽

10.1016/j.fertnstert.2007.11.009 ◽

2009 ◽

Vol 91 (1) ◽

pp. 106-109 ◽

Cited By ~ 12

Author(s):

Banu Kumbak ◽

Ulun Ulug ◽

Burcak Erzik ◽

Hande Akbas ◽

Mustafa Bahceci

Keyword(s):

Pregnancy Loss ◽

Loss Rate ◽

Poor Responder ◽

Clinical Pregnancy

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Combined treatment of prednisone and hydroxychloroquine may improve outcomes of frozen embryo transfer in antinuclear antibody-positive patients undergoing IVF/ICSI treatment

Lupus ◽

10.1177/09612033211055816 ◽

2021 ◽

pp. 096120332110558

Author(s):

Rui Gao ◽

Wei Deng ◽

Cheng Meng ◽

Kemin Cheng ◽

Xun Zeng ◽

...

Keyword(s):

Pregnancy Rate ◽

Embryo Transfer ◽

Pregnancy Loss ◽

Loss Rate ◽

Implantation Rate ◽

Clinical Pregnancy ◽

Frozen Embryo Transfer ◽

Clinical Pregnancy Rate ◽

High Quality ◽

Biochemical Pregnancy

Background The influence of anti-nuclear antibody (ANA) on induced ovulation was controversial, and the effect of prednisone plus hydroxychloroquine (HCQ) treatment on frozen embryo transfer outcomes of in-vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) for ANA-positive women was unclear. Methods Fifty ANA-positive women and one-hundred ANA-negative women matched for age and anti-Mullerian hormone (AMH) were included from a Reproductive Medical Central of a University Hospital. Sixty-one oocytes pick-up (OPU) cycles in ANA+ group and one-hundred OPU cycles in ANA− group were compared; 30 frozen embryo transfer cycles without treatment and 66 with prednisone plus HCQ treatment among ANA-positive women were compared. Results There was no statistical difference in number of retrieved oocytes (13.66 ± 7.71 vs 13.72 ± 7.23, p = .445), available embryos (5.23 ± 3.37 vs 5.47 ± 3.26, p = .347), high-quality embryos (3.64 ± 3.25 vs 3.70 ± 3.52, p = .832), and proportion of high-quality embryos (26.5% vs. 26.7%, p = .940). Biochemical pregnancy rate (33.3% vs. 68.2%, p < .05), clinical pregnancy rate (20.0% vs. 50.1%, p < .05), and implantation rate (5.6% vs. 31.8%, p < .05) were lower, and pregnancy loss rate (83.3% vs. 23.1%, p < .05) was higher in patients with treatment than no treatment. Conclusion The influence of ANA on number of retrieved oocytes, available embryos, high-quality embryos, and proration of high-quality embryos was not found. The treatment of prednisone plus HCQ may improve implantation rate, biochemical pregnancy rate, and clinical pregnancy rate, and reduce pregnancy loss rate in frozen embryo transfer outcomes for ANA-positive women.

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High pregnancy loss rate following implantation of IVF human embryos with extensive fragmentation

Fertility and Sterility ◽

10.1016/j.fertnstert.2008.07.098 ◽

2008 ◽

Vol 90 ◽

pp. S113-S114 ◽

Cited By ~ 1

Author(s):

M. Alikani ◽

G. Tomkin ◽

K. Ferry ◽

M. Garrisi

Keyword(s):

Pregnancy Loss ◽

Loss Rate ◽

Human Embryos

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A significantly higher early pregnancy loss rate is seen with Intracytoplasmic Sperm Injection (ICSI) versus Standard In Vitro Fertilization (IVF)

Fertility and Sterility ◽

10.1016/s0015-0282(03)01451-1 ◽

2003 ◽

Vol 80 ◽

pp. 204

Author(s):

Laurie J. McKenzie ◽

Paula Amato ◽

Ertug Kovanci ◽

Dolores Lamb ◽

Larry Lipshultz ◽

...

Keyword(s):

In Vitro Fertilization ◽

Early Pregnancy ◽

Intracytoplasmic Sperm Injection ◽

Pregnancy Loss ◽

Loss Rate ◽

Early Pregnancy Loss ◽

Vitro Fertilization

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Influence of practitioner expertise during early pregnancy diagnosis on pregnancy loss rate: A controlled, blinded trial

Reproduction in Domestic Animals ◽

10.1111/rda.13033 ◽

2017 ◽

Vol 52 (6) ◽

pp. 1145-1148 ◽

Cited By ~ 1

Author(s):

R Patron ◽

I López-Helguera ◽

F Sebastián ◽

J-L Pesantez-Pacheco ◽

N Pérez-Villalobos ◽

...

Keyword(s):

Early Pregnancy ◽

Pregnancy Loss ◽

Loss Rate ◽

Pregnancy Diagnosis ◽

Blinded Trial

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Increased Pregnancy Loss Rate in Thyroid Antibody Negative Women with TSH Levels between 2.5 and 5.0 in the First Trimester of Pregnancy

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2010-0340 ◽

2010 ◽

Vol 95 (9) ◽

pp. E44-E48 ◽

Cited By ~ 227

Author(s):

Roberto Negro ◽

Alan Schwartz ◽

Riccardo Gismondi ◽

Andrea Tinelli ◽

Tiziana Mangieri ◽

...

Keyword(s):

Pregnancy Loss ◽

Loss Rate ◽

First Trimester ◽

Thyroid Antibody ◽

First Trimester Of Pregnancy ◽

Tsh Levels

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SPIN (Scottish Pregnancy Intervention) study: a multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage

Blood ◽

10.1182/blood-2010-01-267252 ◽

2010 ◽

Vol 115 (21) ◽

pp. 4162-4167 ◽

Cited By ~ 163

Author(s):

Peter Clark ◽

Isobel D. Walker ◽

Peter Langhorne ◽

Lena Crichton ◽

Andrew Thomson ◽

...

Keyword(s):

Pregnancy Loss ◽

Low Dose ◽

Loss Rate ◽

Controlled Trial ◽

Previous Pregnancy ◽

Randomized Controlled ◽

Dose Aspirin ◽

Low Dose Aspirin ◽

Multicenter Randomized Controlled Trial ◽

History Of

To assess whether treatment with enoxaparin and low-dose aspirin, along with intensive pregnancy surveillance, reduces rate of pregnancy loss compared with intensive pregnancy surveillance alone in women with history of 2 or more consecutive previous pregnancy losses, a parallel group, multicenter, randomized controlled trial was performed in the United Kingdom and New Zealand. Participants (n = 294) presenting for initial antenatal care at fewer than 7 weeks' gestation with history of 2 or more consecutive previous pregnancy losses at 24 or fewer weeks' gestation and no evidence of anatomic, endocrine, chromosomal, or immunologic abnormality were randomly assigned to receive either enoxaparin 40 mg subcutaneously and 75 mg of aspirin orally once daily along with intense pregnancy surveillance or intense pregnancy surveillance alone from random assignment until 36 weeks' gestation. The primary outcome measure was pregnancy loss rate. Of the 147 participants receiving pharmacologic intervention, 32 (22%) pregnancy losses occurred, compared with 29 losses (20%) in the 147 subjects receiving intensive surveillance alone, giving an odds ratio of 0.91 (95% confidence interval, 0.52-1.59) of having a successful pregnancy with pharmacologic intervention. Thus, we observed no reduction in pregnancy loss rate with antithrombotic intervention in pregnant women with 2 or more consecutive previous pregnancy losses. The trial was registered at http://www.controlled-trials.com as ISRCTN06774126.

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