Detection of Soluble Receptors for Tumor Necrosis Factor, lnterleukin-2 and lnterleukin-6 in Retroplacental Serum from Normal Pregnant Women

1996 ◽  
Vol 41 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Egil Lien ◽  
Nina-Beate Liabakk ◽  
Rigmor Austgulen
Keyword(s):  
Tumor Necrosis Factor ◽  
Pregnant Women ◽  
Tumor Necrosis ◽  
Soluble Receptors ◽  
Necrosis Factor

Tumor Necrosis Factor and its Soluble Receptors as Potential Diagnostic Markers of Endometriosis

2017 ◽  
Vol 9 (4) ◽  
pp. 275-278
Author(s):  
Ana L. Rocha ◽  
Erica L. Vieira ◽  
Márcia C. Ferreira ◽  
Antonio L. Teixeira ◽  
Fernando M. Reis
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Diagnostic Markers ◽  
Soluble Receptors ◽  
Necrosis Factor

Plasma tumor necrosis factor-α, its soluble receptors and interleukin-1β levels in critically burned patients

Burns ◽  
1998 ◽  
Vol 24 (7) ◽  
pp. 599-603 ◽  
Author(s):  
B Zhang ◽  
Y.H Huang ◽  
Y Chen ◽  
Y Yang ◽  
Z.L Hao ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 1Β ◽  
Soluble Receptors ◽  
Factor Α ◽  
Necrosis Factor

Neopterin, soluble receptors for interleukin-2 and tumor necrosis factor in viral cirrhosis and alcoholic cirrhosis

Pteridines ◽  
2000 ◽  
Vol 11 (2) ◽  
pp. 43-47 ◽  
Author(s):  
Jorge Gonzalez-Calvin ◽  
Gernot P. Tilz ◽  
Francisco Gallego-Rojo ◽  
Marina Torres-Almendros ◽  
Bernhard Widner ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Immune System ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Interleukin 2 ◽  
Alcoholic Cirrhosis ◽  
Serum Concentrations ◽  
Soluble Receptors ◽  
Cell Functions ◽  
Necrosis Factor

AbstractAlcoholic cirrhosis and viral cirrhosis are associated with alterations of immune system function and cytokine production. Our aim was to investigate whether serum concentrations of soluble receptors for interleukin-2 (sIL- 2 R) and tumor necrosis factor (55kD-type, sTNFR-55), and serum neopterin can be used as markers to establish differences in etiology and severity in liver cirrhosis and to determine whether they correlate with laboratory and clinical parameters. Thirty three patients with alcoholic and 15 with viral cirrhosis (classified according to the Child-Pugh score of severity of liver disease) and 43 healthy controls were studied. Serum concentrations of sIL2-R, sTNFR-55 and neopterin were significantly raised in patients. No significant differences between alcoholic and viral cirrhosis were found. The concentrations of sIL-2 Rand sTNFR-55 were significantly higher in patients with more severe disease. There existed correlations b<!tween sIL-2R and sTNFR-55 (rs = 0.50, P < 0.001) and between both soluble receptors and the Child-Pugh score (sTNF-R55: rs = 0.70, p < 0.001; sIL-2R: rs = 0.33, p < 0.05) and serum albumin. The results are likely to reflect that the monocyte-macrophage and T-cell functions are stimulated in patients with liver cirrhosis independently of the etiology of the disease, and the persistent activation of the immune system occurs in cirrhosis even at the end stage of the disease. Chronic immune activation might have deletereous consequences on the evolution of cirrhosis.

scholarly journals Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.

1992 ◽  
Vol 175 (2) ◽  
pp. 323-329 ◽  
Author(s):  
D Aderka ◽  
H Engelmann ◽  
Y Maor ◽  
C Brakebusch ◽  
D Wallach
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Prolonged Treatment ◽  
Tnf Receptors ◽  
Soluble Receptors ◽  
Low Concentrations ◽  
High Concentrations ◽  
Activity Decay ◽  
Necrosis Factor

The receptors for tumor necrosis factor (TNF) exist in cell-associated as well as soluble forms, both binding specifically to TNF. Since the soluble forms of TNF receptors (sTNF-Rs) can compete with the cell-associated TNF receptors for TNF, it was suggested that they function as inhibitors of TNF activity; at high concentrations, the sTNF-Rs indeed inhibit TNF effects. However, we report here that in the presence of low concentrations of the sTNF-Rs, effects of TNF whose induction depend on prolonged treatment with this cytokine are augmented, reflecting an attenuation by the sTNF-Rs of spontaneous TNF activity decay. Evidence that this stabilization of TNF activity by the sTNF-Rs follows from stabilization of TNF structure within the complexes that TNF forms with the sTNF-Rs is presented here, suggesting that the sTNF-Rs can affect TNF activity not only by interfering with its binding to cells but also by stabilizing its structure and preserving its activity, thus augmenting some of its effects.

Soluble receptors released during acute pancreatitis interfere with the detection of tumor necrosis factor-α

2001 ◽  
Vol 29 (5) ◽  
pp. 1023-1026 ◽  
Author(s):  
Emma Folch ◽  
Anna Serrano ◽  
Lluis Sabater ◽  
Emilio Gelpí ◽  
Joan Roselló-Catafau ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Soluble Receptors ◽  
Factor Α ◽  
Necrosis Factor
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