The Role of Exenterative Surgery and Urinary Diversion in Persistent or Locally Recurrent Gynecological Malignancy: Complications and Survival

2010 ◽  
Vol 85 (1) ◽  
pp. 16-22 ◽  
Author(s):  
M. Spahn ◽  
C. Weiss ◽  
P. Bader ◽  
D. Frohneberg ◽  
U.E. Studer ◽  
...  
Keyword(s):  
Urinary Diversion ◽  
Gynecological Malignancy ◽  
Locally Recurrent ◽  
Exenterative Surgery

IS THERE A CHANCE OF CURE FOR WOMEN WITH LOCALLY RECURRENT GYNECOLOGICAL MALIGNANCY AFTER EXENTERATIVE SURGERY AND URINARY DIVERSION?

2009 ◽  
Vol 181 (4S) ◽  
pp. 289-289
Author(s):  
Martin Spahn ◽  
Christel Weiss ◽  
Pia Bader ◽  
Detlef Frohneberg ◽  
Urs E Studer ◽  
...  
Keyword(s):  
Urinary Diversion ◽  
Gynecological Malignancy ◽  
Locally Recurrent ◽  
Exenterative Surgery

scholarly journals Role of static fluid MR urography in detecting post urinary diversion complications

2018 ◽  
Vol 54 (2) ◽  
pp. 173-179
Author(s):  
Amr Farouk Ibrahim Moustafa ◽  
Tamer M. Abd el Rahman ◽  
Amr Abd Elfattah Hassan Gadalla ◽  
Karam Gaber Mohamed ◽  
Ahmed Morsi Moustafa Fahmy ◽  
...  
Keyword(s):  
Urinary Diversion ◽  
Mr Urography ◽  
Static Fluid

scholarly journals Bladder Substitution: The Role of Tissue Engineering and Biomaterials

Processes ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1643
Author(s):  
Martina Casarin ◽  
Alessandro Morlacco ◽  
Fabrizio Dal Moro
Keyword(s):  
Tissue Engineering ◽  
Urinary Diversion ◽  
Mucus Production ◽  
Reconstructive Procedures ◽  
Suitable Material ◽  
Orthotopic Urinary Diversion ◽  
Bladder Substitution ◽  
Materials Used ◽  
Bowel Segments

Tissue engineering could play a major role in the setting of urinary diversion. Several conditions cause the functional or anatomic loss of urinary bladder, requiring reconstructive procedures on the urinary tract. Three main approaches are possible: (i) incontinent cutaneous diversion, such as ureterocutaneostomy, colonic or ileal conduit, (ii) continent pouch created using different segments of the gastrointestinal system and a cutaneous stoma, and (iii) orthotopic urinary diversion with an intestinal segment with spherical configuration and anastomosis to the urethra (neobladder, orthotopic bladder substitution). However, urinary diversions are associated with numerous complications, such as mucus production, electrolyte imbalances and increased malignant transformation potential. In this context, tissue engineering would have the fundamental role of creating a suitable material for urinary diversion, avoiding the use of bowel segments, and reducing complications. Materials used for the purpose of urinary substitution are biological in case of acellular tissue matrices and naturally derived materials, or artificial in case of synthetic polymers. However, only limited success has been achieved so far. The aim of this review is to present the ideal properties of a urinary tissue engineered scaffold and to examine the results achieved so far. The most promising studies have been highlighted in order to guide the choice of scaffolds and cells type for further evolutions.

scholarly journals Increased expression of TET3 predicts unfavorable prognosis in patients with ovarian cancer-a bioinformatics integrative analysis

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Tiefeng Cao ◽  
Wenwei Pan ◽  
Xiaoli Sun ◽  
Huimin Shen
Keyword(s):  
Ovarian Cancer ◽  
Dna Demethylation ◽  
Integrative Analysis ◽  
Gynecological Malignancy ◽  
Kaplan Meier ◽  
The Family ◽  
Elevated Expression ◽  
Integrative Study ◽  
Cancer Tissues

Abstract Ovarian carcinoma is a lethal gynecological malignancy. Women with ovarian cancer (OC) are highly recurrent and typically diagnosed at late stage. Ten-eleven translocation protein 3 (TET3) belongs to the family of ten-eleven translocations (TETs) which induce DNA demethylation and gene regulation in epigenetic level by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Previous studies indicated that TET3 is overexpressed in ovarian cancer tissues. However, the clinic-pathological functions and prognostic values of TET3 remain unclear. Here we performed an integrative study to identify the role of TET3 by bioinformatics analysis. The TET3 expression in ovarian cancer was assessed with Oncomine database, and validated with TCGA and GTEx database. The correlation of TET3 gene alteration and clinic-pathological functions was addressed by integrative analysis of GEO datasets. Then we showed mainly TET3 gain and diploid but less deletion in ovarian cancer by copy number alteration (CNA) or mutation analysis with cBioPortal. Furthermore, by using Kaplan-Meier plotter (K-M plotter), we evaluated that high TET3 level was associated with poor survival in ovarian cancer patients, which was validated with analysis by PrognoScan database and gene differential analyses with TCGA and GTEx. This is the first study demonstrated that elevated expression of TET3 is associated with poor clinic-pathological functions, poor prognosis, wherein TET3, which presents epigenetic changes or methylation changes, might be served as a diagnostic marker or therapeutic target for ovarian cancer.

The role of surgery for locally recurrent and second recurrent rectal cancer with metastatic disease

2020 ◽  
Vol 35 ◽  
pp. 328-335
Author(s):  
Aya Tanaka ◽  
Kay Uehara ◽  
Toshisada Aiba ◽  
Atsushi Ogura ◽  
Toshiki Mukai ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Metastatic Disease ◽  
Recurrent Rectal Cancer ◽  
Locally Recurrent

The role of interventional radiology in the management of intra-and extra-Peritoneal leakage in patients who have undergone continent urinary diversion

1997 ◽  
Vol 20 (4) ◽  
pp. 274-279 ◽  
Author(s):  
Leonard Bodner ◽  
John L. Nosher ◽  
Randall Siegel ◽  
Tadeus Russer ◽  
Kenneth Cummings ◽  
...  
Keyword(s):  
Interventional Radiology ◽  
Urinary Diversion ◽  
Continent Urinary Diversion

scholarly journals SOX9: Advances in Gynecological Malignancies

2021 ◽  
Vol 11 ◽  
Author(s):  
Huan Chen ◽  
Yujie He ◽  
Xiangping Wen ◽  
Shihong Shao ◽  
Yujie Liu ◽  
...  
Keyword(s):  
Prognostic Value ◽  
Molecular Mechanisms ◽  
Cell Morphogenesis ◽  
Female Reproductive System ◽  
Transcription Factor Family ◽  
Gynecological Malignancy ◽  
Stem Cell Maintenance ◽  
Gynecological Malignancies ◽  
Cell Maintenance

Transcription factors of the SOX family were first discovered in mammals in 1990. The sex-determining region Y box 9 belongs to the SOX transcription factor family. It plays an important role in inducing tissue and cell morphogenesis, survival, and many developmental processes. Furthermore, it has been shown to be an oncogene in many tumors. Gynecological malignancies are tumors that occur in the female reproductive system and seriously threaten the lives of patients. Common gynecological malignancies include ovarian cancer, cervical cancer, and endometrial cancer. So far, the molecular mechanisms related to the incidence and development of gynecological malignancies remain unclear. This makes it particularly important to discover their common causative molecule and thus provide an effective therapeutic target. In recent years, studies have found that multiple mechanisms are involved in regulating the expression of the sex-determining region Y box 9, leading to the occurrence and development of gynecological malignancies. In this review, we discuss the prognostic value of SOX9 expression and the potential of targeting SOX9 for gynecological malignancy treatment. We also discuss progress regarding the role of SOX9 in gynecological malignancy pathogenesis through its mediation of important mechanisms, including tumor initiation and proliferation, apoptosis, migration, invasion, chemoresistance, and stem cell maintenance.

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