Longitudinal Associations between Endogenous Melatonin Production and Reported Sleep Duration from Childhood to Early Adulthood

Daytime oral melatonin typically exerts soporific and thermoregulatory effects; however, it is not clear whether these effects reflect the normal physiological response to endogenous nocturnal melatonin production. We infused melatonin at doses that produced physiological and supraphysiological steady-state levels in 24 young adults during two daytime bed rest protocols. From 1000 to 1630, subjects were infused intravenously with saline or melatonin in counterbalanced order. Each group of eight subjects received melatonin (and saline) infusions at one dose rate: 0.04 μg ⋅ h−1 ⋅ kg body wt−1 (low), 0.08 μg ⋅ h−1 ⋅ kg−1(medium), or 8.0 μg ⋅ h−1 ⋅ kg−1(high). Low and medium melatonin infusions produced plasma and saliva levels within the normal nocturnal range observed in young adults. These levels were not associated with any changes in rectal, hand, forehead, or tympanic temperatures or with subjective sleepiness. High melatonin produced supraphysiological plasma and saliva levels and was associated with a significant attenuation in the daytime increase in rectal temperature, significantly increased hand temperature, and greater sleepiness. It is not yet clear whether the thermoregulatory and soporific effects of daytime supraphysiological melatonin administration are equivalent to the physiological responses to endogenous melatonin.

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Do gender and racial/ethnic disparities in sleep duration emerge in early adulthood? Evidence from a longitudinal study of U.S. adults

Sleep Medicine ◽

10.1016/j.sleep.2017.03.031 ◽

2017 ◽

Vol 36 ◽

pp. 133-140 ◽

Cited By ~ 8

Author(s):

Katrina M. Walsemann ◽

Jennifer A. Ailshire ◽

Calley E. Fisk ◽

Lauren L. Brown

Keyword(s):

Longitudinal Study ◽

Sleep Duration ◽

Early Adulthood ◽

Ethnic Disparities ◽

Racial Ethnic

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Habitual Sleep, Sleep Duration Differential, and Weight Change Among Adults

Innovation in Aging ◽

10.1093/geroni/igab046.129 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. 35-35

Author(s):

Yin Liu ◽

Mari Palta ◽

Jodi Barnet ◽

Max Roberts ◽

Erika Hagen ◽

...

Keyword(s):

Body Mass Index ◽

Cohort Study ◽

Data Collection ◽

Sleep Duration ◽

Men And Women ◽

Longitudinal Associations ◽

The Difference ◽

Nighttime Sleep ◽

Inadequate Sleep ◽

Over Time

Abstract We assessed longitudinal associations between diary-measured sleep duration and clinically assessed body mass index (BMI) among 784 men and women enrolled in the Wisconsin Sleep Cohort Study (mean [SD] age = 51.1 [8.0] years at baseline). The outcome was BMI (kg/m2). Key predictors were habitual sleep duration (defined as average weekday nighttime sleep duration) and sleep duration differential (defined as the difference between average weekday and average weekend nighttime sleep duration) at each data collection wave. Men with shorter habitual sleep duration on weekdays had higher BMI than men with longer habitual sleep duration on weekdays. Participants with larger differentials between weekday and weekend sleep duration experienced more rapid BMI gain over time for both men and women. Inadequate sleep, characterized as shorter habitual sleep during weekdays and larger weekday-weekend sleep differential, is positively associated with BMI levels and trajectories among men and women in mid-to-late life.

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