scholarly journals Long-Term Recurrence Rate of Large and Difficult to Treat Cutaneous Squamous Cell Carcinomas after Superficial Radiotherapy

Dermatology ◽  
2012 ◽  
Vol 224 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Marjam J. Barysch ◽  
Nina Eggmann ◽  
Mirjam Beyeler ◽  
Renato G. Panizzon ◽  
Burkhardt Seifert ◽  
...  
2004 ◽  
Vol 171 (4S) ◽  
pp. 503-503
Author(s):  
Roger M. Mueller ◽  
Bernard Descoeudres ◽  
Werner W. Hochreiter ◽  
Urs E. Studer ◽  
Hansjoerg Danuser

2001 ◽  
Vol 19 (2) ◽  
pp. 127-136 ◽  
Author(s):  
John C. Grecula ◽  
David E. Schuller ◽  
Roy Smith ◽  
Chris A. Rhoades ◽  
Subir Nag ◽  
...  

2007 ◽  
Vol 35 (3) ◽  
pp. 189-192 ◽  
Author(s):  
Oliver Zernial ◽  
Ingo N. Springer ◽  
Patrick Warnke ◽  
Franz Härle ◽  
Christian Risick ◽  
...  

2016 ◽  
Vol 75 (6) ◽  
pp. 275-282
Author(s):  
Tohru Furusaka ◽  
Akira Matsuda ◽  
Akane Tanaka ◽  
Hiroshi Matsuda ◽  
Takeshi Asakawa ◽  
...  

2017 ◽  
Vol 10 (1) ◽  
pp. 106-111 ◽  
Author(s):  
Yota Sato ◽  
Taku Fujimura ◽  
Yumi Kambayashi ◽  
Akira Tsukada ◽  
Takanori Hidaka ◽  
...  

Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Our present case suggested that IL-17/IL-17R signaling might contribute to the carcinogenesis of cSCC.


2019 ◽  
Vol 47 (5) ◽  
pp. 1057-1061 ◽  
Author(s):  
Hervé Thomazeau ◽  
Tristan Langlais ◽  
Alexandre Hardy ◽  
Jonathan Curado ◽  
Olivier Herisson ◽  
...  

Background: An isolated arthroscopic Bankart repair carries a high mid- and long-term risk of recurring instability. Preoperative patient selection based on the Instability Severity Index Score should improve outcomes. Purpose: To report the overall long-term recurrence rate for isolated Bankart repair, investigate the predictive factors for recurrence, analyze time to recurrence, and determine a quantitative cutoff point for recurrence in terms of Instability Severity Index Score. Study Design: Cohort study; Level of evidence, 2. Methods: This was a prospective multicenter study. Inclusion criteria were recurring anterior instability and an Instability Severity Index Score of 4 or less. Of the 125 patients included, 20 patients had a score of 0, 31 patients scored 1, 29 patients scored 2, 34 patients scored 3, and 11 patients scored 4. All centers used the same arthroscopic technique and rehabilitation protocol. Follow-up data were collected at 3, 6, 12, and 24 months and 3 and 9 years. The primary endpoint was recurrence of instability (total or partial dislocation). The statistical analysis was performed by use of the software package SAS 9.4. Results: We initially identified 328 patients, of whom 125 patients were prospectively included. The main reason for excluding the 202 patients was the presence of bony lesions, which carry 2 points each in the Instability Severity Index Score (humeral head notch and/or glenoid lesion visible on standard radiographs). Of the 125 eligible patients, 73% were athletes and 22.5% competitors; 16% were lost at the last follow-up. At the endpoint, 23% had experienced a recurrence after a mean interval of 35 months (range, 5.5-103 months). No statistical differences were found between patients with and without bony lesions in the overall group of 125 patients or in the subgroup with an Instability Severity Index Score of 3 or 4 points ( P = .4). According to univariate analysis, the only predictive factor for recurrence was age less than 20 years at the time of surgery, with a 42% rate of recurrence in this group ( P = .03). Multivariate analysis showed that the Instability Severity Index Score was the only predictive factor with a quantitative cutoff point (namely, a score of ≤2 points) that was statistically associated with a decreased long term recurrence rate ( P = .02). The recurrence rate was 10% for a preoperative Instability Severity Index Score of 2 or less compared with 35.6% for a score of 3 or 4. The survival curves demonstrated no new dislocations after year 4 for patients with an Instability Severity Index Score of up to 2 points. Conclusion: In a preselected population, mainly without bony lesions, the Instability Severity Index Score cutoff value that provides an acceptable recurrence rate at 9 years after isolated Bankart repair is 2 out of 10.


2000 ◽  
Vol 87 (4) ◽  
pp. 502-503 ◽  
Author(s):  
J. R. Barwell ◽  
M. Taylor ◽  
A. S. K. Ghauri ◽  
L. K. Phillips ◽  
M. R. Whyman ◽  
...  

ISRN Surgery ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Guillaume Buiret ◽  
Clémentine Daveau ◽  
Guillaume Landry ◽  
Carole Colin ◽  
Jean-Christian Pignat ◽  
...  

Objective. To analyze the functional impact of the various possible treatments of oropharyngeal squamous cell carcinomas to find the main prognostic factors of dysphagia induced by these treatments. Patients. Clinical data from 254 patients treated for squamous cell carcinoma of the oropharynx between 1998 and 2003 were retrospectively analyzed. A multivariate model enabled us to evaluate the role of each potentially harmful factor on swallowing. Main Outcome Measures. The significant factors influencing the consumption of liquid, pasty, and normal food were the same: the initial T stage and the type of treatment. Conclusion. Whatever the possible and selected treatment was, the impact on the functional capacities, and thus, the quality of life of the patients was considerable. Even though we could not significantly demonstrate exclusive radiotherapy caused more long-term undesirable effects than surgery followed by radiotherapy, our daily practice has shown that we should favour the latter.


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