scholarly journals Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis

2017 ◽  
Vol 10 (1) ◽  
pp. 106-111 ◽  
Author(s):  
Yota Sato ◽  
Taku Fujimura ◽  
Yumi Kambayashi ◽  
Akira Tsukada ◽  
Takanori Hidaka ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Immunohistochemical Staining ◽  
Juvenile Dermatomyositis ◽  
Immunosuppressive Agents ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Squamous Cell Carcinomas ◽  
Inflammatory Conditions ◽  
Term Administration ◽  
Atypical Keratinocytes

Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Our present case suggested that IL-17/IL-17R signaling might contribute to the carcinogenesis of cSCC.

Long-Term Follow-up on an Intensified Treatment Regimen for Advanced Resectable Head and Neck Squamous Cell Carcinomas

2001 ◽  
Vol 19 (2) ◽  
pp. 127-136 ◽  
Author(s):  
John C. Grecula ◽  
David E. Schuller ◽  
Roy Smith ◽  
Chris A. Rhoades ◽  
Subir Nag ◽  
...  
Keyword(s):  
Head And Neck ◽  
Treatment Regimen ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Long Term Follow Up

scholarly journals Long-Term Observation of Advanced Nasopharyngeal Squamous Cell Carcinomas Treated Using a Combination Strategy

2016 ◽  
Vol 75 (6) ◽  
pp. 275-282
Author(s):  
Tohru Furusaka ◽  
Akira Matsuda ◽  
Akane Tanaka ◽  
Hiroshi Matsuda ◽  
Takeshi Asakawa ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Combination Strategy ◽  
Long Term Observation

scholarly journals Alimentation Impact of Treatments of 254 Oropharyngeal Cancers (1998–2003)

ISRN Surgery ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Guillaume Buiret ◽  
Clémentine Daveau ◽  
Guillaume Landry ◽  
Carole Colin ◽  
Jean-Christian Pignat ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Daily Practice ◽  
Squamous Cell Carcinomas ◽  
Functional Capacities ◽  
The Impact ◽  
Normal Food ◽  
Significant Factors

Objective. To analyze the functional impact of the various possible treatments of oropharyngeal squamous cell carcinomas to find the main prognostic factors of dysphagia induced by these treatments. Patients. Clinical data from 254 patients treated for squamous cell carcinoma of the oropharynx between 1998 and 2003 were retrospectively analyzed. A multivariate model enabled us to evaluate the role of each potentially harmful factor on swallowing. Main Outcome Measures. The significant factors influencing the consumption of liquid, pasty, and normal food were the same: the initial T stage and the type of treatment. Conclusion. Whatever the possible and selected treatment was, the impact on the functional capacities, and thus, the quality of life of the patients was considerable. Even though we could not significantly demonstrate exclusive radiotherapy caused more long-term undesirable effects than surgery followed by radiotherapy, our daily practice has shown that we should favour the latter.

Immunohistochemical Staining of p16 in Squamous Cell Carcinomas of the Genital and Extragenital Area

2011 ◽  
Vol 102 (6) ◽  
pp. 439-447
Author(s):  
R. Corbalán-Vélez ◽  
I. Oviedo-Ramírez ◽  
J.A. Ruiz-Maciá ◽  
P. Conesa-Zamora ◽  
M. Sánchez-Hernández ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Immunohistochemical Staining ◽  
Squamous Cell Carcinomas

scholarly journals Actinic Keratosis: A New Approach to the Treatment / Aktinična Keratoza: Novi Pristup Lečenju

2009 ◽  
Vol 1 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Đorđije Karadaglić ◽  
Marina Jovanović
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Actinic Keratosis ◽  
Squamous Cell Carcinomas ◽  
Molecular Characteristics ◽  
Solar Ultraviolet Radiation ◽  
New Approach ◽  
Atypical Keratinocytes ◽  
Surrounding Skin

Abstract Actinic keratosis is an intraepidermal proliferation of transformed, atypical keratinocytes, induced by exposure to solar ultraviolet radiation. Many authors believe that it is the earliest form of squamous cell carcinoma. More than 40% of all metastatic squamous cell carcinomas develop from actinic keratosis. The clinical, histological and molecular characteristics of actinic keratosis are those of squamous cell carcinomas. Since it can be extremely hard to distinguish actinic keratosis from some squamous cell carcinomas, treatment can be rather difficult. The best treatment of actinic keratosis is its prevention. The main reason for therapy which is universally accepted, is prevention of squamous cell carcinoma. A number of options are available, but when considering the efficacy, invasive procedures remain the standard treatment. Treatment of individual lesions may prevent further progression of actinic damage present in the surrounding skin

scholarly journals Transformation from adenocarcinoma to squamous cell carcinoma associated with long‑term administration of EGFR‑TKIs

2020 ◽  
Vol 13 (6) ◽  
pp. 1-1
Author(s):  
Tomohiro Haruki ◽  
Atsuyuki Nakanishi ◽  
Shinji Matsui ◽  
Yoshiteru Kidokoro ◽  
Yasuaki Kubouchi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Term Administration ◽  
Egfr Tkis

Actinic keratoses contiguous with squamous cell carcinomas are mostly non-hyperkeratotic and with severe dysplasia

2021 ◽  
pp. jclinpath-2021-207497
Author(s):  
Ida M Heerfordt ◽  
Thomas Poulsen ◽  
Hans Christian Wulf
Keyword(s):  
Squamous Cell Carcinoma ◽  
Skin Biopsy ◽  
Stratum Corneum ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Squamous Cell Carcinomas ◽  
Severe Dysplasia ◽  
Strongly Correlated ◽  
Inclusion Criteria ◽  
Epidermal Thickness

AimsActinic keratosis (AK) is a precursor of cutaneous squamous cell carcinoma (SCC). No validated parameters can predict which AKs will progress into SCCs, but especially thick AKs are under suspicion. The clinical and histopathological thickness of AKs is strongly correlated. This study aimed to investigate the thicknesses and degree of dysplasia of AKs contiguous with SCCs assuming these AKs represent the AKs that have undergone malignant transformation.MethodsFiles of the Pathology Department, Hospital of Southern Jutland, Denmark, were reviewed. 111 cases met the inclusion criteria: a skin biopsy containing an invasive SCC. All SCCs merged with an AK at the edge. Degree of dysplasia, epidermal thickness and stratum corneum thicknesses of AKs were measured.ResultsAll AKs showed severe dysplasia. Most AKs had a stratum corneum thickness under 0.1 mm and an epidermal thickness under 0.5 mm, corresponding to clinically thin and non-hyperkeratotic AKs.ConclusionsOur result suggests malignant progression potential of AKs regardless of thickness.

MUC4 Expression in Non–Small Cell Lung Carcinomas: Relationship to Tumor Histology and Patient Survival

2007 ◽  
Vol 131 (4) ◽  
pp. 593-598
Author(s):  
Kun Y. Kwon ◽  
Jae Y. Ro ◽  
Nicholas Singhal ◽  
Deanna E. Killen ◽  
Anna Sienko ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Patient Survival ◽  
Large Cell ◽  
Small Cell ◽  
Squamous Cell Carcinomas ◽  
Small Cell Lung ◽  
Term Survival ◽  
Long Term Survival ◽  
Muc4 Expression

Abstract Context.—Mucin 4 (MUC4) is a high-molecular-weight membrane–bound glycoprotein that is expressed in the foregut before epithelial differentiation. It is found in normal adult airway epithelium, non–small cell lung carcinoma (NSCLC) and in other human malignancies independent of mucus secretion. Although its tissue distribution has been studied, its utility in predicting prognosis in NSCLC is unknown. Objective.—To evaluate the relationship between MUC4 overexpression and long-term survival in patients with NSCLC. Design.—Immunohistochemical staining for MUC4 was performed on formalin-fixed, paraffin-embedded tissue samples from 343 cases of NSCLC arranged in a high-density tissue microarray. Information about long-term survival and tumor stage was collected for all patients. Semiquantitative assessment of MUC4 staining was correlated with survival (Kaplan-Meier analysis). Results.—MUC4 was frequently expressed in adenocarcinomas (151/187 [81%]), squamous cell carcinomas (69/ 88 [78%]), adenosquamous carcinomas (6/8 [75%]), and large cell carcinomas (33/60 [55%]). High levels of expression (combined score, 2+/3+) for MUC4 were more characteristic of adenocarcinomas (126/187 [68%]) and adenosquamous carcinomas (6/8 [75%]) than of squamous cell carcinomas (46/88 [52%]) and large cell carcinomas (17/60 [28%]) (P < .001). In patients with stage I and II adenocarcinoma, there was a trend toward longer patient survival with higher levels of MUC4 immunoreactivity compared with lower levels (P = .11). Conclusion.—MUC4 expression is common in pulmonary adenocarcinomas and may indicate a more favorable prognosis in early-stage adenocarcinomas.

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