scholarly journals Population Reference Values and Prevalence Rates following Universal Screening for Subclinical Hypothyroidism during Pregnancy of an Afro-Caribbean Cohort

2014 ◽  
Author(s):  
Nadine Johnson ◽  
Vikash Chatrani ◽  
Anna-Kay Taylor-Christmas ◽  
Eric Choo-Kang ◽  
Monica Smikle ◽  
...  
Keyword(s):  
Reference Values ◽  
Subclinical Hypothyroidism ◽  
Universal Screening ◽  
Prevalence Rates

Reference values and universal screening of thyroid function in the first trimester of the population of pregnant women in Toledo (Spain)

2015 ◽  
Vol 62 (7) ◽  
pp. 358-360
Author(s):  
Julia Sastre-Marcos ◽  
Florentino Val-Zaballos ◽  
Miguel Ángel Ruiz-Ginés ◽  
José Saura-Montalbán ◽  
Mariano Veganzones-Pérez
Keyword(s):  
Pregnant Women ◽  
Thyroid Function ◽  
Reference Values ◽  
Universal Screening ◽  
First Trimester

Reference values and universal screening of thyroid dysfunction in pregnant women

2014 ◽  
Vol 61 (6) ◽  
pp. 336-338
Author(s):  
Gonzalo Díaz-Soto ◽  
Encarna Largo ◽  
Cristina Álvarez-Colomo ◽  
Isabel Martínez-Pino ◽  
Daniel de Luis
Keyword(s):  
Pregnant Women ◽  
Reference Values ◽  
Universal Screening ◽  
Thyroid Dysfunction

scholarly journals Do we need to screen and treat pregnant women for subclinical hypothyroidism? A cross sectional study in a rural tertiary centre in Kerala, India

2017 ◽  
Vol 6 (3) ◽  
pp. 781
Author(s):  
Radha K. R. ◽  
Nishu Sugunan ◽  
Resmy C. R.
Keyword(s):  
Pregnant Women ◽  
Subclinical Hypothyroidism ◽  
Universal Screening ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Neonatal Hypothyroidism ◽  
In Pregnancy

Background: Hypothyroidism (HT) is associated with maternal and perinatal morbidity. Subclinical HT rather than overt occur in pregnancy, because overt HT causes infertility. Treatment of overt HT was beneficial in reducing the fetal and maternal complications, Usefulness of correcting subclinical hypothyroidism was doubtful, hence Universal screening of pregnant women was not recommended.Methods: Cross sectional study, conducted in the department of obstetrics and gynecology, Government Medical College, Thrissur, Kerala, India. 50 consecutive cases of subclinical hypothyroidism in pregnancy were analyzed for Thyroid function, antenatal, natal, postnatal complications. Perinatal complications, including neonatal hypothyroidism also noted. Statistical analysis done using computer software Epi info3.4. Data expressed in its frequency and percentage, continuous data in mean.Results: All women in the study group received levothyroxine during pregnancy from time of diagnosis. At the time of delivery 84% women were euthyroid and 16% hypothyroid. Complications like anemia 36%, abruption 4%, and postpartum hemorrhage 6% showed a statistically significant association, while pre-eclampsia 20%, preterm labor 22% had no statistically significant association. Comparing the women who are euthyroid as a result of levothyroxine supplementation to women inadequately treated, complications like anemia (33% versus 50%, p value 0.042), abruption (0% versus 4%, p value0.023), PPH (2% versus 6%, p value 0.014) were significantly less in well controlled.Conclusions: Significant association was noted between inadequately treated hypothyroidism and maternal complications like anaemia, placental abruption, placenta previa, PPH, preterm delivery, and caesarean section rate for foetal distress. Universal screening of pregnant women for thyroid status is recommended.

scholarly journals First trimester thyroid function in pregnant women residing in Saint Petersburg (Russia): reference values and risk of gestational diabetes

2018 ◽  
Vol 21 (1) ◽  
pp. 34-41
Author(s):  
Polina V. Popova ◽  
Ekaterina S. Shilova ◽  
Alexandra S. Tkachuk ◽  
Alexandra V. Dronova ◽  
Anna D. Anopova ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Pregnant Women ◽  
Reference Values ◽  
Subclinical Hypothyroidism ◽  
Reference Interval ◽  
First Trimester ◽  
Specific Reference ◽  
Thyroid Status ◽  
Saint Petersburg ◽  
Increased Risk

Background. Subclinical hypothyroidism during pregnancy and gestational diabetes mellitus (GDM) is known to be associated with maternal and child morbidity. The concept of subclinical dysfunction of the thyroid gland in pregnant women depends on the population-specific and trimester-specific reference values so fixed universal cutoff concentrations for thyroid-stimulating hormone (TSH) that were recommended earlier now are put under the question. Population-specific and trimester-specific reference values have not been defined for pregnant women residing in Saint Petersburg. The data concerning the association of maternal thyroid status with GDM development are controversial. Aims. The aim of the study was to determine the reference values of TSH and free thyroxin (fT4) in the first trimester of pregnancy in women living in St. Petersburg, and to assess the relationship between thyroid status and the risk of subsequent development of GDM. Materials and methods. The levels of TSH, fT4 and thyroid peroxidase antibodies (TPO-Ab) were analyzed in 503 pregnant women before the 14th week of gestation. The women underwent oral glucose tolerance test (OGTT) at 2428 weeks to find out those with GDM. The association between thyroid function, thyroid autoimmunity and the risk of GDM we estimated. Results. The reference values for TSH were 0.07 4.40 mU /L, and for fT4 11.7 20.3 pmol/L. The prevalence of subclinical hypothyroidism in the 503 pregnant women was 16.9% according to the diagnostic criteria of TSH 2.5 mIU / L and 3.8% using our calculated reference interval. Hypothyroxinemia was registered in 5,3% using reference values recommended by diagnostic tests manufacturer and in 2,8% according to our calculated reference interval for fT4. GDM was diagnosed in 23% of women. Logistic regression analysis showed associations of hypothyroxinemia and TPO-Ab-positivity with the increased risk of GDM that remained significant after adjustments on age and body mass index (BMI) [adjusted OR (95% CI) = 7.39 (1.2742.93) for hypothyroxinemia, p=0.026; and adjusted OR (95% CI) = 2.02 (1.014.04) for TPO-Ab-positivity, p=0.047). Conclusions. Reference intervals for first trimester TSH and fT4 have been established for pregnant women living in St. Petersburg. Hypothyroxinemia and TPO-Ab-positivity were associated with the increased risk of GDM.

scholarly journals Thyroid disorder in antenatal women in sub-himalayan region: a need for universal screening

2017 ◽  
Vol 6 (8) ◽  
pp. 3445
Author(s):  
Swati Dubey ◽  
Anup Pradhan
Keyword(s):  
Gestational Age ◽  
Subclinical Hypothyroidism ◽  
Universal Screening ◽  
Thyroid Dysfunction ◽  
Fetal Outcome ◽  
Thyroid Disorder ◽  
Singleton Pregnancy ◽  
Adverse Pregnancy ◽  
Pregnant State ◽  
In Pregnancy

Background: Thyroid dysfunction constitutes the second most common endocrine disorder of pregnancy, associated with adverse maternal and fetal outcome and is often overlooked in pregnancy due to their nonspecific symptoms and the hypermetabolic pregnant state. Objective of present study was to establish the prevalence of thyroid dysfunction, study the effects in pregnancy in sub-himalayan population and whether universal screening for thyroid dysfunction is required.Methods: The study was conducted on 200 patients in the age group of 20 to 35 years with a singleton pregnancy and gestational age between 6 to 24 weeks.Results: In the 200 women screened, the prevalence of thyroid dysfunction was found to be 14% with 8% having subclinical hypothyroidism while an equal percentage of 2% having clinical hypothyroidism, subclinical hyperthyroidism and clinical hyperthyroidism. The mean age of patients with subclinical hypothyroidism was 28.6 ± 4.9 years, with thyroid disorder in pregnancy being significantly more common in primigravida. Statistically significant association was found between patients with thyroid dysfunction and abortions, preeclampsia, preterm labor, small for gestational age, low birth weight, and admission to NICU.Conclusions: Prevalence of thyroid dysfunction was found to be high in our study, particularly subclinical hypothyroidism and was associated with adverse pregnancy outcomes; hence, more research is required in the Sub-Himalayan goitre belt to assess the magnitude of the problem and formulate universal screening protocols in this particular subset of the Indian population accordingly.

scholarly journals Subclinical hypothyroidism: a ‘laboratory-induced’ condition?

2015 ◽  
Vol 173 (4) ◽  
pp. 499-505 ◽  
Author(s):  
Karlien L M Coene ◽  
Ayse Y Demir ◽  
Maarten A C Broeren ◽  
Pauline Verschuure ◽  
Eef G W M Lentjes ◽  
...  
Keyword(s):  
Reference Values ◽  
Subclinical Hypothyroidism ◽  
Analytical Method ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Reference Intervals ◽  
Reference Ranges ◽  
Thyroid Pathology ◽  
Design And Methods

ObjectiveIn current literature and guidelines, there is a tendency to define absolute TSH concentrations at which patient follow-up or even pharmaceutical intervention should be initiated. As TSH concentrations depend on the analytical method/platform used for TSH quantification, absolute cut-off values may pose threats for uniform clinical decision-making. In this study we therefore set out to clarify to what extent the method/platform and the reference values applied for TSH influence the clinical interpretation of thyroid parameters.Design and methodsWe retrospectively analyzed anonymous TSH results from the Dutch external quality assessment program (EQAS) in relation to reference values advised by different manufacturers. We also examined TSH/free thyroxin (fT4) reference ranges and prevalence of thyroid pathology among different Dutch laboratories, including four cases in which a switch in the measuring platform was made.ResultsOur data show that interpretation of thyroid parameters is not only influenced by between-method/platform variation, but is also substantially affected by the variation in TSH/fT4 reference intervals applied in individual laboratories. Additionally, we show that the transition to a novel analytical method/platform can result in a shift in the prevalence of thyroid pathology, especially for subclinical hypothyroidism.ConclusionsSubclinical hypothyroidism can be a ‘laboratory-induced’ condition. This is an undesirable situation in regard to the clinical implications such a diagnosis can have for patients.

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