Cochlear Implants as a Treatment Option for Unilateral Hearing Loss, Severe Tinnitus and Hyperacusis

Tinnitus is an incapacitating condition commonly affecting cochlear implant (CI) candidates. The aim of this clinical study is to assess the long-term effects of CI treatment in patients with severe-to-profound, sensorineural, unilateral hearing loss (UHL) and incapacitating tinnitus. We performed a prospective Cochlear™ company-sponsored multicentre study in five Spanish centres. Sixteen patients with UHL and incapacitating tinnitus, which was indicated by a Tinnitus Handicap Inventory (THI) score >58%, received a Nucleus® CI in their deaf ear. The study design includes repeated within-subject measures on hearing, tinnitus, hyperacusis and quality of life up to 12 months after initial CI fitting. In addition to hearing loss and tinnitus, all patients suffered from hyperacusis. Most patients had a sudden hearing loss and received a CI within 2 years after their hearing loss. Preliminary 6-month, post-CI activation data of 13 subjects showed that the majority of patients perceived a subjective benefit from CI treatment, which was assessed using the THI, a Visual Analogue Scale of tinnitus loudness/annoyance and the Speech, Spatial and Qualities of Hearing Scale. Preliminary 12-month data of 7 subjects showed that most patients also perceived a degree of relief from their hyperacusis. One patient showed no improvements in any of the applied scales, which could be explained by partial insertion of the electrode due to obstruction of the cochlea by otosclerosis. In conclusion, CI can successfully be used in the treatment of UHL patients with accompanying severe tinnitus and hyperacusis. Implantation resulted in hearing benefits and a durable relief from tinnitus and hyperacusis in the majority of patients. These findings support the hypothesis that pathophysiological mechanisms after peripheral sensorineural hearing loss are at least partly reversible when hearing is restored with a CI.

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Investigation of the long-term effects of unilateral hearing loss in adults

British Journal of Audiology ◽

10.3109/03005368809077805 ◽

1988 ◽

Vol 22 (2) ◽

pp. 113-118 ◽

Cited By ~ 27

Author(s):

V. Colletti ◽

F. G. Fiorino ◽

M. Carner ◽

R. Rizzi

Keyword(s):

Hearing Loss ◽

Unilateral Hearing Loss ◽

Long Term Effects

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Long-term Impact of Adenotonsillectomy on the Quality of Life of Children with Sleep-disordered breathing

International Archives of Otorhinolaryngology ◽

10.1055/s-0040-1709195 ◽

2020 ◽

Author(s):

Juliana Alves Sousa Caixeta ◽

Jessica Caixeta Silva Sampaio ◽

Vanessa Vaz Costa ◽

Isadora Milhomem Bruno da Silveira ◽

Carolina Ribeiro Fernandes de Oliveira ◽

...

Keyword(s):

Quality Of Life ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Sleep Disordered Breathing ◽

Long Term Effects ◽

Obstructive Sleep ◽

Long Term Impact ◽

Disordered Breathing

Abstract Introduction Adenotonsillectomy is the first-line treatment for obstructive sleep apnea secondary to adenotonsillar hypertrophy in children. The physical benefits of this surgery are well known as well as its impact on the quality of life (QoL), mainly according to short-term evaluations. However, the long-term effects of this surgery are still unclear. Objective To evaluate the long-term impact of adenotonsillectomy on the QoL of children with sleep-disordered breathing (SDB). Method This was a prospective non-controlled study. Children between 3 and 13 years of age with symptoms of SDB for whom adenotonsillectomy had been indicated were included. Children with comorbities were excluded. Quality of life was evaluated using the obstructive sleep apnea questionnaire (OSA-18), which was completed prior to, 10 days, 6 months, 12 months and, at least, 18 months after the procedure. For statistical analysis, p-values lower than 0.05 were defined as statistically significant. Results A total of 31 patients were enrolled in the study. The average age was 5.2 years, and 16 patients were male. The OSA-18 scores improved after the procedure in all domains, and this result was maintained until the last evaluation, done 22 ± 3 months after the procedure. Improvement in each domain was not superior to achieved in other domains. No correlation was found between tonsil or adenoid size and OSA-18 scores. Conclusion This is the largest prospective study that evaluated the long-term effects of the surgery on the QoL of children with SDB using the OSA-18. Our results show adenotonsillectomy has a positive impact in children's QoL.

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Yoga therapy to reduce fatigue in cancer: effects of reminder e-mails and long-term efficacy

Supportive Care in Cancer ◽

10.1007/s00520-021-06345-z ◽

2021 ◽

Author(s):

Teresa Zetzl ◽

Andre Pittig ◽

Agnes Renner ◽

Birgitt van Oorschot ◽

Elisabeth Jentschke

Keyword(s):

Quality Of Life ◽

Cancer Patients ◽

Mediation Model ◽

Long Term Effects ◽

Long Term Outcomes ◽

Cognitive Fatigue ◽

Yoga Therapy ◽

Life Data

Abstract Objective To examine the efficacy of reminder e-mails to continue yoga therapy on practice frequency and fatigue in cancer patients and long-term effects of yoga on fatigue, depression, and quality of life. Methodology One hundred two cancer patients who completed an 8-week yoga therapy were randomly allocated to two groups: reminder (N = 51) vs. no-reminder group (N = 51). After completing yoga therapy, the reminder group received weekly e-mails for 24 weeks, which reminded them of practicing yoga, whereas the no-reminder group did not. Primary outcomes were fatigue and practice frequency, and long-term outcomes were fatigue, depression, and quality of life. Data were assessed using questionnaires after yoga therapy (T1) and 6 months after completing yoga therapy (T2). Result A significantly stronger reduction of general (p = 0.038, d = 0.42) and emotional fatigue (p = 0.004, d = 0.59) and a higher increase of practice frequency (p = 0.015, d = 0.52) between T1 and T2 were found for the reminder group compared to the no-reminder group. In the mediation model, practice frequency as a mediator partially explained the changes in emotional fatigue (indirect effect B = − 0.10). Long-term effects of yoga therapy regarding fatigue, depression, and quality of life were found (F > 7.46, p < 0.001, d > 0.54). Conclusion Weekly reminder e-mails after yoga therapy can positively affect general and emotional fatigue and help cancer patients with fatigue establish a regular yoga practice at home. However, higher practice frequency did not lead to higher physical or cognitive fatigue improvement, suggesting other factors that mediate efficacy on physical or cognitive fatigue, such as mindfulness or side effects of therapy.

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Long-Term Effects of Doxazosin, Finasteride and Combination Therapy on Quality of Life in Men with Benign Prostatic Hyperplasia

The Journal of Urology ◽

10.1016/j.juro.2013.01.061 ◽

2013 ◽

Vol 190 (1) ◽

pp. 187-193 ◽

Cited By ~ 16

Author(s):

Chyng-Wen Fwu ◽

Paul W. Eggers ◽

Steven A. Kaplan ◽

Ziya Kirkali ◽

Jeannette Y. Lee ◽

...

Keyword(s):

Quality Of Life ◽

Benign Prostatic Hyperplasia ◽

Combination Therapy ◽

Prostatic Hyperplasia ◽

Long Term Effects

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LONG-TERM EFFECTS OF OTITIS MEDIA A TEN-YEAR COHORT STUDY OF ALASKAN ESKIMO CHILDREN

PEDIATRICS ◽

10.1542/peds.52.4.577 ◽

1973 ◽

Vol 52 (4) ◽

pp. 577-585 ◽

Cited By ~ 1

Author(s):

Gary J. Kaplan ◽

J. Kenneth Fleshman ◽

Thomas R. Bender ◽

Carol Baum ◽

Paul S. Clark

Keyword(s):

Hearing Loss ◽

Otitis Media ◽

Verbal Ability ◽

Significant Loss ◽

Long Term Effects ◽

Normal Range ◽

History Of ◽

Conductive Component ◽

Verbal Development

Histories of ear disease, otoscopic examinations, and audiologic, intelligence, and achievement tests were obtained from a cohort of 489 Alaskan Eskimo children who have been followed through the first ten years of life. Seventy-six per cent had experienced one or more episodes of otitis media since birth. Of these, 78% had their first attack during their first two years of life. Perforations and scars were present in 41%. A hearing loss of 26 decibels or greater was present in 16%, and an additional 25% were in the normal range but had a measurable air-bone gap. Children with a history of otitis media prior to 2 years of age and a hearing loss of 26 decibels or greater had a statistically significant loss of verbal ability and were behind in total reading, total math, and language. In addition, children who had an early onset of otitis media but now had normal hearing with a conductive component were also adversely affected in verbal areas. The number of otitis media episodes was related to tympanic membrane abnormalities, hearing loss, and low verbal and achievement scores. These findings indicate that otitis media has been a significant cause of morbidity in Alaskan Eskimo children, and its onset during the critical years of language development as well as the number of episodes play an important role in impairing verbal development.

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Long-term effects of bilateral subthalamic nucleus stimulation on health-related quality of life in advanced Parkinson's disease

Movement Disorders ◽

10.1002/mds.20786 ◽

2006 ◽

Vol 21 (6) ◽

pp. 746-753 ◽

Cited By ~ 41

Author(s):

Andrew Siderowf ◽

Jurg L. Jaggi ◽

Sharon X. Xie ◽

Catherine Loveland-Jones ◽

Lewis Leng ◽

...

Keyword(s):

Quality Of Life ◽

Subthalamic Nucleus ◽

Health Related Quality ◽

Long Term Effects ◽

Advanced Parkinson’S Disease ◽

Subthalamic Nucleus Stimulation ◽

Related Quality ◽

Health Related

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Physical occupational exposures during working life and quality of life after labour market exit: results from the GAZEL study

10.31219/osf.io/tng6t ◽

2016 ◽

Author(s):

Loretta G. Platts ◽

Gopalakrishnan Netuveli ◽

Elizabeth Webb ◽

Marie Zins ◽

Marcel Goldberg ◽

...

Keyword(s):

Quality Of Life ◽

Working Conditions ◽

Occupational Exposures ◽

Working Life ◽

Life Course Perspective ◽

Physical And Mental Health ◽

Long Term Effects ◽

Physical Danger

Objective: To investigate variations in quality of life at older ages, we take a life course perspective to analyse long-term effects of physical working conditions upon quality of life after retirement. In doing so, we study to what extent these associations are explained by individuals’ health at older ages. Method: We use administrative data and self-administered questionnaire responses from the French GAZEL cohort. Quality of life was assessed with CASP-19 in 2009 and related to three types of physical working conditions during previous working life: (1) ergonomic strain, (2) physical danger and (3) exposures to chemicals. Health was assessed in 2007 with the SF-36 Health Survey. Multiple regressions were calculated in retired men only, controlling for important confounders including social position. Results: In contrast to men, few women were exposed to strenuous and dangerous working conditions in this cohort and were not included in subsequent analyses. Negative effects on retired men's quality of life were found for the physical occupational exposures of ergonomic strain and physical danger, but not for chemical exposures. Effects were attenuated after the introduction of physical and mental health to the models, indicating an indirect effect of physical working conditions upon quality of life via health. Conclusion: Adverse physical working conditions have long-term consequences for health and quality of life at older ages. Improvements to physical working conditions may improve individuals’ quality of life over the long term.

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Long-term results of tonsillectomy in professional opera singers: a pilot study

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20201669 ◽

2020 ◽

Vol 6 (5) ◽

pp. 815

Author(s):

Pedro Clarós ◽

Aleksandra Sobolewska ◽

María Del Carmen Pujol ◽

Astrid Clarós-Pujol ◽

Andrés Clarós

Keyword(s):

Survey Study ◽

Long Term Results ◽

Long Term Effects ◽

Recurrent Tonsillitis ◽

Voice Performance ◽

The Moment ◽

Opera Singers ◽

The Voice

Background: The primary goal of this study was to evaluate the long-term influence of tonsillectomy on the quality of life and voice performance of opera singers. Survey study which was reviewing the long-term effects of tonsillectomy. Methods: Retrospective review of patients’ records and surveys in which patients have answered the questions about the influence of tonsillectomy on their voice. A total group of 30 singers was included in the study. They answered the questions about the indications for surgery, symptoms, and changes in their voice after surgery. The study group consisted of 19 women and 11 men. Mean age was 18.53 years old at the moment of surgery. The group included eleven sopranos, six mezzos, two contraltos, four tenors, five baritones, and one bass singer. Results: A most common indication for tonsillectomy in opera singers was recurrent tonsillitis and was present in over 83% of cases. After surgery, the voice performance was better in 60% of cases, breathing improved in 50% of cases, voice emission was higher in 53% of cases. Over 80% of singers would recommend that surgery to another opera singer.Conclusions: Singers evaluated long-term influence of tonsillectomy as positive. Over 80% admitted improved effect on emission and the function of voice.

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Exploration of physico-chemical parameters and ionic constituents from groundwater used in irrigation of Tangail district, Bangladesh

Research in Agriculture Livestock and Fisheries ◽

10.3329/ralf.v3i1.27865 ◽

2016 ◽

Vol 3 (1) ◽

pp. 115-119

Author(s):

Elina Aziz ◽

Md Younus Mia ◽

Nowara Tamanna Meghla

Keyword(s):

Trace Metal ◽

Irrigation Water ◽

Agricultural Crops ◽

Soil Ecosystem ◽

Long Term Effects ◽

Chemical Parameters ◽

Physico Chemical ◽

Fe And Mn

The study was conducted for exploration of physico-chemical parameters and ionic constituents of groundwater used in irrigation of four upazilas namely Tangail Sadar, Kalihati, Delduar and Nagarpur upazila of Tangail district during the months of March, April and May of 2015. The physico-chemical parameters (pH, EC and TDS), ionic constituents (Ca2+, Mg2+, Na+, K+, Cl-, CO32-, HCO3-, PO43- and SO42-) and trace metal (Fe and Mn) were analyzed to assess the quality of irrigation in relation to soil properties and crop growth. The pH of groundwater indicates slightly alkaline in nature. As regards to EC the groundwater was in good class and medium salinity hazards in quality for irrigation and the concentration of TDS indicates water as fresh water. The concentration of Ca2+, Mg2+, Na+, K+, Cl-, CO32-, HCO3-, PO43- and SO42- of groundwater were recorded within the permissible limit for irrigation and these ions might not create hazardous impact on soil ecosystem for growing crops. The trace amount of Fe and Mn was detected in irrigation water. In the study area, the groundwater was within the recommended limit and would not create problem for irrigation and that have not long term effects on irrigating agricultural crops which could be safely used for irrigation purposes.Res. Agric., Livest. Fish.3(1): 115-119, April 2016

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