Clonogenic Cell Inactivation and Local Tumour Control of a Human Melanoma Xenograft Exposed to Single Doses of Radiation1

SummaryRadiobiological and cell biological knowledge is increasingly used to further improve local tumour control or to reduce normal tissue damage after radiotherapy. Important research areas are evolving which need to be addressed jointly by nuclear medicine and radiation oncology. For this differences of the biological distribution of diagnostic and therapeutic nuclides compared with the more homogenous dose-distribution of external beam radiotherapy have to be taken into consideration. Examples for interdisciplinary biology-based cancer research in radiation oncology and nuclear medicine include bioimaging of radiobiological parameters characterizing radioresistance, bioimage-guided adaptive radiotherapy, and the combination of radiotherapy with molecular targeted drugs.

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Effect of single and multiple administration of an O ? 6 -benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model

Cancer Chemotherapy and Pharmacology ◽

10.1007/s002800050657 ◽

1997 ◽

Vol 40 (3) ◽

pp. 266-272 ◽

Cited By ~ 38

Author(s):

Stephen R. Wedge ◽

Julia K. Porteous ◽

E. S. Newlands

Keyword(s):

Xenograft Model ◽

Human Melanoma ◽

Multiple Administration ◽

Human Melanoma Xenograft ◽

Melanoma Xenograft

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PO-1926 Enhanced local tumour control by combining proton radiation and immunotherapy

Radiotherapy and Oncology ◽

10.1016/s0167-8140(21)08377-8 ◽

2021 ◽

Vol 161 ◽

pp. S1642

Author(s):

M. Horsman ◽

S. Nielsen ◽

M. Sitarz ◽

M. Høyer ◽

B. Sørensen

Keyword(s):

Proton Radiation ◽

Tumour Control ◽

Local Tumour Control ◽

Local Tumour

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Comparing plaque brachytherapy and proton therapy for choroidal melanoma: a review of the literature

Journal of Radiotherapy in Practice ◽

10.1017/s1460396909990197 ◽

2010 ◽

Vol 9 (1) ◽

pp. 53-61

Author(s):

Jeremy P. Appleton ◽

Peter Bridge

Keyword(s):

Conservative Treatment ◽

Proton Therapy ◽

Normal Tissue ◽

Treatment Options ◽

Choroidal Melanoma ◽

Review Of The Literature ◽

Tumour Control ◽

Local Tumour Control ◽

Local Tumour ◽

Plaque Brachytherapy

AbstractThe aims of conservative treatment in patients with ocular melanoma are globe retention, good visual acuity (VA) and local control. Two well-established radiation conservative treatment options are proton beam radiotherapy and episcleral plaque brachytherapy (EPB). Patients who receive treatment with either of these options will experience some degree of radiation-related ocular complications and poor VA. The purpose of this review of the literature is to establish whether there is a significant clinical difference in normal tissue morbidity and local tumour control between proton therapy and EPB, and whether this difference can justify the purchase and implementation of additional proton therapy facilities. Based on this review, evidence suggested that both treatment options are comparable, and that neither proton therapy nor EPB is clinically superior than the other regarding normal tissue morbidity and local tumour control. This review highlighted the need for further research on a larger scale in order to bridge the gap that is apparent within the literature.

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Extensive systemic metastases from primary central nervous system haemangiopericytoma

BJR|case reports ◽

10.1259/bjrcr.20190081 ◽

2020 ◽

Vol 6 (2) ◽

pp. 20190081

Author(s):

Chi Long Ho ◽

Jeremy JH Lam ◽

Robert Chun Chen

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Fatal Outcome ◽

Imaging Features ◽

Tumour Control ◽

Local Tumour Control ◽

Meningeal Tumour ◽

Local Tumour ◽

The Central Nervous System ◽

Extracranial Metastases

Primary intracranial tumours rarely metastasise outside of the central nervous system (CNS). This report describes a rare case of recurrent meningeal haemangiopericytoma with extensive systemic metastases, which eventually resulted in a fatal outcome. We discuss some prevailing theories as to the rarity of extracranial metastases from primary CNS haemangiopericytoma, and elucidate the epidemiology, imaging features, differential diagnosis, treatment, and prognosis of this unusual but surprisingly aggressive meningeal tumour. Besides aggressive treatment for local tumour control, patients with primary CNS haemangiopericytoma require long-term post-treatment surveillance to detect systemic metastases.

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