scholarly journals Extensive systemic metastases from primary central nervous system haemangiopericytoma

2020 ◽  
Vol 6 (2) ◽  
pp. 20190081
Author(s):  
Chi Long Ho ◽  
Jeremy JH Lam ◽  
Robert Chun Chen
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Fatal Outcome ◽  
Imaging Features ◽  
Tumour Control ◽  
Local Tumour Control ◽  
Meningeal Tumour ◽  
Local Tumour ◽  
The Central Nervous System ◽  
Extracranial Metastases

Primary intracranial tumours rarely metastasise outside of the central nervous system (CNS). This report describes a rare case of recurrent meningeal haemangiopericytoma with extensive systemic metastases, which eventually resulted in a fatal outcome. We discuss some prevailing theories as to the rarity of extracranial metastases from primary CNS haemangiopericytoma, and elucidate the epidemiology, imaging features, differential diagnosis, treatment, and prognosis of this unusual but surprisingly aggressive meningeal tumour. Besides aggressive treatment for local tumour control, patients with primary CNS haemangiopericytoma require long-term post-treatment surveillance to detect systemic metastases.

Solitary Fibrous Tumors in the Central Nervous System

2003 ◽  
Vol 127 (4) ◽  
pp. 432-439 ◽  
Author(s):  
Tarik Tihan ◽  
Michael Viglione ◽  
Marc K. Rosenblum ◽  
Alessandro Olivi ◽  
Peter C. Burger
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Biological Behavior ◽  
Clinicopathologic Features ◽  
Distinct Entity ◽  
Total Resection ◽  
Solitary Fibrous Tumors ◽  
The Central Nervous System ◽  
Extracranial Metastases

Abstract Context.—Solitary fibrous tumors (SFTs) of the central nervous system are rare neoplasms that usually present as dura-based masses and clinically resemble meningiomas. Histologically, they can be similar to fibrous meningioma or hemangiopericytoma (HPC). In particular, densely cellular regions seen in some SFTs can be indistinguishable from HPC. Little is known about the biological behavior of SFTs, although most seem amenable to total resection. Objectives.—To define the clinicopathologic spectrum of SFTs in the central nervous system and to outline their differences from HPC and meningioma. Design.—We present the clinicopathologic features of 18 patients with SFT and compare them with those of an age- and sex-matched cohort of HPCs. Results.—Eleven SFTs were supratentorial, 3 were infratentorial, and 4 were intraspinal. Four of the 18 tumors were intra-axial (2 in the lateral ventricles and 2 within the spinal cord). Histologically, SFTs were similar to their soft tissue counterparts. Six tumors (6/18) had densely cellular regions, and 1 tumor showed frankly anaplastic features. All but 3 patients underwent gross total resection, and there were no metastases or tumor-related mortalities during the median follow-up of 40 months. In contrast, there were 15 local recurrences (83%), 5 extracranial metastases (27%), and 4 tumor-related deaths (22%) in the HPC cohort. Conclusions.—Our study presents the clinicopathologic features of SFT as a distinct entity from both meningioma and HPC. We also present unusual examples of anaplastic, intraventricular, and intramedullary spinal SFTs that expand the clinicopathologic spectrum of these uncommon and sometimes diagnostically difficult neoplasms.

Imaging features of multifocal primary rhabdoid tumour of the central nervous system with meningeal and spinal metastases

2003 ◽  
Vol 33 (4) ◽  
pp. 275-277 ◽  
Author(s):  
Peter De Mot ◽  
Philippe Demaerel ◽  
Guy Wilms ◽  
Stefaan Van Gool ◽  
Raf Sciot
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Spinal Metastases ◽  
Imaging Features ◽  
Rhabdoid Tumour ◽  
The Central Nervous System

Extracranial Metastases of Oligodendroglioma

Neurosurgery ◽  
1981 ◽  
Vol 8 (3) ◽  
pp. 391-396 ◽  
Author(s):  
Nelson G. Ordóñez ◽  
Alberto G. Ayala ◽  
Milam E. Leavens
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lymph Nodes ◽  
Masseter Muscle ◽  
Lumbar Vertebrae ◽  
Cervical Lymph Nodes ◽  
Extraneural Metastases ◽  
The Central Nervous System ◽  
The Right ◽  
Extracranial Metastases

Abstract The case of a 33-year-old woman with oligodendroglioma with extraneural metastases involving the masseter muscle, the cervical lymph nodes, the lumbar vertebrae, and the right iliac bone is described. Oligodendroglioma with metastases outside the central nervous system is extremely rare, and only a very few cases have been reported.

scholarly journals Clinicopathological and imaging features of lipoastrocytoma: Case report

2017 ◽  
Vol 31 (1) ◽  
pp. 32-38
Author(s):  
Laxminadh Sivaraju ◽  
Saritha Aryan ◽  
Nandita Ghosal ◽  
Alangar S Hegde
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Nervous System ◽  
Pediatric Population ◽  
Pleomorphic Xanthoastrocytoma ◽  
Imaging Features ◽  
Total Excision ◽  
Favorable Prognosis ◽  
The Central Nervous System

Lipidized tumors of the central nervous system are very uncommon, with only a few cases described. We report a case of a 25-year-old woman with a tumor involving the left premotor area. She underwent gross total excision. Histologically, the tumor was composed of glial fibrillary acidic protein-positive glial cells with areas of lipidization. A diagnosis of lipoastrocytoma was rendered. At three-year follow-up she was doing well, supporting the presumed favorable prognosis of these uncommon tumors. Absence of xanthochromic appearance, mitotic activity, necrosis and poor reticulin activity are the differentiating features from the pleomorphic xanthoastrocytoma. We highlighted that these tumors involve the adult and pediatric population and distribute in both supratentorial and infratentorial compartments as well as in the spinal cord.

scholarly journals Neurological involvement of IgG4-related disease: description of a case and review of the literature

2017 ◽  
Vol 31 (2) ◽  
pp. 196-202 ◽  
Author(s):  
Marco Varrassi ◽  
Camilla Gianneramo ◽  
Francesco Arrigoni ◽  
Paolo Cerrone ◽  
Patrizia Sucapane ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lower Limbs ◽  
Neurological Involvement ◽  
Imaging Features ◽  
Spinal Root ◽  
Related Disease ◽  
Igg4 Related Disease ◽  
Clinical Presentations ◽  
The Central Nervous System

IgG4-related disease is a recently discovered pathological entity, histologically characterised by fibrosis and IgG4-positive plasma cell infiltration. This condition may virtually involve every site of the organism, with a various range of clinical presentations. The most commonly affected organ is the pancreatic gland, but it can also involve the biliary tract, salivary and lacrimal glands, kidneys, orbital tissues, lymph nodes, lungs and many others. More recently, IgG4-related disease has been demonstrated to involve, in rare cases, also the central nervous system, with a pattern mainly characterised by hypertrophic pachymeningitis. In this paper we evaluated the clinical and magnetic resonance imaging features of the IgG4-related disease in the central nervous system, reporting a case of brain and spinal cord involvement. In our case, in fact, a 62-year-old man complaining of paresthesia, burning dysesthesia and severe hyposthenia in the lower limbs presented with inflammatory pseudotumour with orbital involvement and focal dural and spinal root thickening.

scholarly journals Therapeutic decision making in autoimmune and inflammatory disorders of the central nervous system in children

2016 ◽  
Author(s):  
Russell Clive Dale
Keyword(s):  
Decision Making ◽  
Central Nervous System ◽  
Nervous System ◽  
Fatal Outcome ◽  
Decision Making Process ◽  
Therapeutic Decision ◽  
Inflammatory Disorders ◽  
Sydenham Chorea ◽  
The Central Nervous System ◽  
Therapeutic Decision Making

Autoimmune and inflammatory disorders of the central nervous system can result in significant morbidity and mortality. Through the recognition of syndromes using diagnostic biomarkers, the clinician is now able to use immune suppressive therapies to improve outcomes. However, the therapeutic decision-making process is complex. The clinician has to balance the risk of disease, with the risk of treatment side effects. To achieve this balance, it is important to understand the natural history of disease, the risk of residual disability, the risk of relapse, and risk of a fatal outcome. It is also important to have some understanding of the pathological processes, as some of the entities have more reversible processes, whereas others have destructive processes. This review will assess the dynamic nature of this decision-making process, and compare some of the more severe diseases such as neuromyelitis optica, anti-N-methyl-D-aspartate receptor encephalitis and opsoclonus myoclonus ataxia syndrome, with disorders with more favourable outcomes such as Sydenham chorea and post-infectious cerebellar ataxia. 

scholarly journals Spectrum of neurovascular complications from central nervous system infections (viral, bacterial and fungal)

BJR|Open ◽  
2019 ◽  
Vol 1 (1) ◽  
pp. bjro.20180024 ◽  
Author(s):  
Christine Tang ◽  
Nikhil Kaushik Patel ◽  
Robert Miller ◽  
Timothy Beale ◽  
Harpreet Hyare
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Fungal Infections ◽  
Imaging Features ◽  
Central Nervous System Infections ◽  
Common Features ◽  
Pictorial Review ◽  
The Central Nervous System ◽  
Potential Mode ◽  
Infectious Organism

In the following pictorial review, common and uncommon neurovascular complications associated with a spectrum of viral, bacterial and fungal infections involving the central nervous system will be illustrated. These complications include cerebral vascular insult, venous thrombosis, vasculitis and aneurysm formation. They can occur as separate entities but are often inter-related. The imaging features of neurovascular complication related to infections can provide clues and aid diagnosis when considering the potential mode of infectious spread and the type of potential infectious organism involved. The radiological appearances vary from common features that are shared by several types of pathogens to typical characteristics of a type of infectious organism.

Primary neuroblastoma of the central nervous system with spontaneous extracranial metastases

1973 ◽  
Vol 38 (2) ◽  
pp. 226-231 ◽  
Author(s):  
Antonio S. Henriquez ◽  
David M. Robertson ◽  
W. John S. Marshall
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Lymph Node ◽  
Adrenal Glands ◽  
Content Type ◽  
Cerebral Neuroblastoma ◽  
Prior Surgery ◽  
The Central Nervous System ◽  
Extracranial Metastases ◽  
Fine Print

✓ A case of spontaneous extracranial metastases from a cerebral neuroblastoma in the absence of prior surgery is reported. The tumor was discovered incidently through biopsy of an enlarged retro-auricular lymph node in an apparently well 7-year-old boy who had not previously received surgery or radiotherapy. The patient died 15 months later. Autopsy excluded neuroblastoma of the adrenal glands or the sympathetic chains.

scholarly journals Treatment of Pediatric Life Threatening Amitriptilin Intoxication with Plasma Exchange

2021 ◽  
Vol 8 (1) ◽  
pp. 01-03
Author(s):  
Deniz Karakaya
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Plasma Exchange ◽  
Fatal Outcome ◽  
Gastric Lavage ◽  
Volume Of Distribution ◽  
Tricyclic Antidepressant ◽  
High Dose ◽  
Life Threatening ◽  
The Central Nervous System

Tricyclic antidepressant (TCA) overdose is one of the most common causes of serious drug poisoning in children. Amitriptyline is a major TCA drug that is used widely. Tricyclic antidepressant intoxications are very important because of their severe adverse effects and probable fatal outcomes. It may cause cardiovascular, respiratory and neurological side effects. Poisoning results in hypotension, cardiac dysrhythmia, depression of the central nervous system (CNS) and seizures. The most common effects on the central nervous system are agitation, lethargy, seizures, and coma. Cardiovascular toxicities manifest itself especially with electrocardiographic (ECG) abnormalities, arrhythmias, and refractory hypotension and they are the leading cause of fatal outcome. Treatments in TCA overdose are mainly conservative including gastric lavage, activated charcoal and vasopressors for hypotension, sodium bicarbonate for dysrhythmias, and benzodiazepines for seizures. Magnesium sulfate (MgSO4) also has an effective role in the treatment of fatal cardiac arrhythmias occurring in high-dose amitriptyline intoxication. Intravenous lipid emulsions have been increasingly studied as antidotes to reverse acute, life-threatening drug toxicity. Unpredictable and poor results with hemoperfusion (HP) and hemodialysis (HD) should be expected, as the drug binds rapidly to tissues and has a large volume of distribution. But beside it, in the last few years, HP has been successfully used in severe TCA overdose, especially in patients with persistent respiratory, cardiac, and neurologic symptoms. Besides all these, recently, plasma exchange, have been increasingly used. A reduction of plasma levels by 63% after plasmapheresis in TCA poisoning has been reported. Here, we report a successful treatment of plasma exchange 3 year patient with amitriptyline overdose who had arrhythmias and seizures that wasn't respond all to conservative therapies.

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