Computed Tomography in Diabetes insipidus

Abstract An 18-year-old woman presented with visual disturbance and endocrine dysfunction (diabetes insipidus, delayed puberty, hypothyroidism, hypoadrenalism, and hyperprolactinemia). Computed tomography and enhanced cisternography showed a single hypothalamic mass, which proved at biopsy to be histiocytosis X. Further studies showed the disease to be restricted to the hypothalamus. The patient was treated with hormonal replacement therapy, but her visual acuity continued to worsen. Visual acuity improved after low-dose irradiation of the pituitary fossa and hypothalamus, which also led to disappearance of the mass. This case shows that localized hypothalamic histiocytosis X can be diagnosed and treated successfully before other systems become involved.

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Computed tomography in diabetes insipidus: posterior empty sella

British Journal of Radiology ◽

10.1259/0007-1285-54-639-263 ◽

1981 ◽

Vol 54 (639) ◽

pp. 263-265 ◽

Cited By ~ 10

Author(s):

G. D. Marano ◽

J. A. Horton ◽

A. M. Vazquez

Keyword(s):

Computed Tomography ◽

Diabetes Insipidus ◽

Empty Sella

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Computed Tomography in Diabetes Insipidus

Journal of Computer Assisted Tomography ◽

10.1097/00004728-197906000-00002 ◽

1979 ◽

Vol 3 (3) ◽

pp. 309-316 ◽

Cited By ~ 17

Author(s):

Claude Manelfe ◽

Jean-Pierre Louvet

Keyword(s):

Computed Tomography ◽

Diabetes Insipidus

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Effect of ADH on Rat Renal Papilla, an Ultrastructural and Cytochemical Study

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100072496 ◽

1973 ◽

Vol 31 ◽

pp. 410-411

Author(s):

C. N. Sun ◽

H. J. White ◽

E. J. Towbin

Keyword(s):

Electron Microscopy ◽

Diabetes Insipidus ◽

Renal Papilla ◽

Milk Diet ◽

Intercellular Spaces ◽

Cytochemical Study ◽

Collecting Tubule ◽

Concentrate Urine ◽

Staining Techniques ◽

Collecting Tubules

Diabetes insipidus and compulsive water drinking are representative of two categories of antidiuretic hormone (ADH) lack. We studied a strain of rats with congenital diabetes insipidus homozygote (DI) and normal rats on an isocaloric fortified dilute milk diet. In both cases, the collecting tubules could not concentrate urine. Special staining techniques, Alcian Blue-PAS for light microscopy and lanthanum nitrate for electron microscopy were used to demonstrate the changes in interstitial mucopolysaccharides (MPS). The lanthanum staining was done according to the method of Khan and Overton.Electron microscopy shows cytoplasmic lesions, vacules, swelling and degenerating mitochondria and intercellular spaces (IS) in the collecting tubule cells in DI and rats on milk diet.

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X-ray microtomography

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100107058 ◽

1988 ◽

Vol 46 ◽

pp. 998-999

Author(s):

H.W. Deckman ◽

B.F. Flannery ◽

J.H. Dunsmuir ◽

K.D' Amico

Keyword(s):

Computed Tomography ◽

Internal Structure ◽

Imaging Technique ◽

Three Dimensional ◽

Tissue Structure ◽

Individual Element ◽

X Ray ◽

Non Invasive ◽

Panoramic Imaging ◽

Three Dimensional Images

We have developed a new X-ray microscope which produces complete three dimensional images of samples. The microscope operates by performing X-ray tomography with unprecedented resolution. Tomography is a non-invasive imaging technique that creates maps of the internal structure of samples from measurement of the attenuation of penetrating radiation. As conventionally practiced in medical Computed Tomography (CT), radiologists produce maps of bone and tissue structure in several planar sections that reveal features with 1mm resolution and 1% contrast. Microtomography extends the capability of CT in several ways. First, the resolution which approaches one micron, is one thousand times higher than that of the medical CT. Second, our approach acquires and analyses the data in a panoramic imaging format that directly produces three-dimensional maps in a series of contiguous stacked planes. Typical maps available today consist of three hundred planar sections each containing 512x512 pixels. Finally, and perhaps of most import scientifically, microtomography using a synchrotron X-ray source, allows us to generate maps of individual element.

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