Intraocular Passive Transfer of Allergy to Tuberculin with Plasma Fractions

2015 ◽  
pp. 808-808
Author(s):  
C. B. Favour
Keyword(s):  
Passive Transfer ◽  
Plasma Fractions

scholarly journals FAILURE TO TRANSFER TUBERCULIN SENSITIVITY PASSIVELY WITH PLASMA FRACTIONS CONTAINING ALPHA GLOBULIN

1956 ◽  
Vol 104 (6) ◽  
pp. 935-945 ◽  
Author(s):  
N. Joel Ehrenkranz ◽  
Byron H. Waksman
Keyword(s):  
Guinea Pigs ◽  
Passive Transfer ◽  
Skin Tests ◽  
C Reactive Protein ◽  
Skin Reactions ◽  
Reactive Protein ◽  
Cervical Adenitis ◽  
Tuberculin Sensitivity ◽  
Plasma Fractions ◽  
Fraction I

We are unable to confirm the observations reported by Cole and Favour that passive transfer of plasma fractions containing alpha globulin (IV + V or IV-10) from tuberculin-sensitive guinea pigs confers delayed sensitivity to tuberculoprotein upon normal animals. In guinea pigs with chronic cervical adenitis due to infection with group C hemolytic streptococci, injection of fraction IV + V and repeated skin tests with PPD induced indurated skin reactions of 9 to 10 mm., maximal at 24 hours, and, in one experiment, a positive tissue culture response to tuberculin. It is suggested that this reactivity was actively induced. Normal or infected recipients of fraction I + II + III from the plasma of tuberculin-sensitive donors manifested edematous responses to tuberculopolysaccharide, maximal at 4 to 6 hours, as reported. Skin tests with pneumococcal C polysaccharide revealed no evidence of passive transfer of C-reactive protein in fractions I + II + III or IV + V.

scholarly journals CORRELATIONS BETWEEN PLASMA PROTEIN FRACTIONS, ANTIBODY TITERS, AND THE PASSIVE TRANSFER OF DELAYED AND IMMEDIATE CUTANEOUS REACTIVITY TO TUBERCULIN PPD AND TUBERCULOPOLYSACCHARIDES

1955 ◽  
Vol 101 (4) ◽  
pp. 391-420 ◽  
Author(s):  
Leon R. Cole ◽  
Cutting B. Favour
Keyword(s):  
Plasma Protein ◽  
Guinea Pigs ◽  
Gamma Globulin ◽  
Passive Transfer ◽  
Tuberculin Sensitivity ◽  
Plasma Fraction ◽  
Plasma Fractions ◽  
Antibody Titers ◽  
Cutaneous Reactivity

Guinea pigs sensitized with tubercle bacilli demonstrate a dual allergic response mediated by two chemically distinct plasma fractions: 1. Antibody to tuberculopolysaccharide is located exclusively in fraction II (gamma globulin). This fraction will passively transfer systemic anaphylaxis and urticarial type skin reactivity to tuberculopolysaccharide, and contains the Middlebrook-Dubos antibody. 2. Antibody to tuberculoprotein is contained exclusively in a new plasma fraction called fraction IV-10. By Cohn's Method X, fraction IV-10 is a part of fraction IV (alpha globulin) and to a lesser extent V (albumin). This fraction will passively transfer to normal guinea pigs a delayed type skin sensitivity to tuberculin PPD which is maximal between 18 and 30 hours, and it contains the Boyden antibody. When fractions II and IV-10 are combined, the antibody to tuberculopolysaccharide inhibits the passive transfer of delayed type reactivity. Combination of these two fractions does not alter their separate in vitro hemagglutinating properties. Adsorption of IV-10 with Boyden sensitized cells removes its ability to transfer delayed type tuberculin sensitivity. Adsorption of II with Middlebrook-Dubos-sensitized cells removes its capacity to effect passive transfer of immediate type reactivity to tuberculopolysaccharides.

Herpes gestations with identical lesions in the newborn. Passive transfer of the disease?

1976 ◽  
Vol 112 (8) ◽  
pp. 1129-1131 ◽  
Author(s):  
T. P. Chorzelski
Keyword(s):  
Passive Transfer

The Hemostatic Mechanism after Open-Heart Surgery

1978 ◽  
Vol 39 (02) ◽  
pp. 474-487 ◽  
Author(s):  
E R Cole ◽  
F Bachmann ◽  
C A Curry ◽  
D Roby
Keyword(s):  
Extracorporeal Circulation ◽  
Heart Surgery ◽  
Polyacrylamide Gel Electrophoresis ◽  
Open Heart Surgery ◽  
Coagulation System ◽  
Open Heart ◽  
Time Activity ◽  
Post Surgery ◽  
Plasma Fractions ◽  
The Mean

SummaryA prospective study in 13 patients undergoing open-heart surgery with extracorporeal circulation revealed a marked decrease of the mean one-stage prothrombin time activity from 88% to 54% (p <0.005) but lesser decreases of factors I, II, V, VII and X. This apparent discrepancy was due to the appearance of an inhibitor of the extrinsic coagulation system, termed PEC (Protein after Extracorporeal Circulation). The mean plasma PEC level rose from 0.05 U/ml pre-surgery to 0.65 U/ml post-surgery (p <0.0005), and was accompanied by the appearance of additional proteins as evidenced by disc polyacrylamide gel electrophoresis of plasma fractions (p <0.0005). The observed increases of PEC, appearance of abnormal protein bands and concomitant increases of LDH and SGOT suggest that the release of an inhibitor of the coagulation system (similar or identical to PIVKA) may be due to hypoxic liver damage during extracorporeal circulation.

Sign in / Sign up

Export Citation Format

Share Document