scholarly journals Intervention for Dysbiosis in Children Born by C-Section

2018 ◽  
Vol 73 (Suppl. 3) ◽  
pp. 33-39 ◽  
Author(s):  
Ruggiero Francavilla ◽  
Fernanda Cristofori ◽  
Maria Elena Tripaldi ◽  
Flavia Indrio

The symbiotic relationship between microbes and human is fundamental for a physiological development and health. The microbiome of the newborn undergoes to dramatic changes during the process of birth and in the first thousand days of life. Mother Nature provided us with the best possible start to achieve eubiosis: vaginal delivery to receive our mother’s microbiome and breast milk that favours the establishment of beneficial bacteria. Infants deprived of one or both of these evolutionary gifts undergo to important modification of the microbial communities leading to a state of dysbiosis enhancing the chance of the emergence of a variety of immune, inflammatory and metabolic disorders. Are we able to imitate nature? Is there any intervention for dysbiosis in children born by cesarean section? In this review we will try to answer to this intriguing question on the basis of the most recent scientific evidences.

Author(s):  
Deepti D. Sharma ◽  
Kavita A. Chandnani

Background: Induction of labour can be defined as “Artificial initiation of uterine contractions before the onset of spontaneous labour, after the period of viability, by any methods, for purpose of vaginal delivery.” The key factor for a successful induction is the status of cervix, its form, consistency and dilatation which is determined by the Bishop score. In case of unfavourable cervix or in the pregnancies remote from the term; prostaglandins are more effective than any other method of induction. Introduction of misoprostol, PGE1 analogue, for the induction of labour in 1993 and its approval for clinical use by ACOG (American College of Obstetrics and Gynecology) in 1999 has been the most significant advancement. It is the latest drug for induction of labour which is cheap and stable at room temperature and is being used worldwide in different doses and by various routes. We compared the most commonly preferred two routes; vaginal and oral in terms of success of induction and noted the adverse events and side effects in both routes.Methods: This was a prospective comparative study carried out at SBKSMIRC (Shrimati Bhikhiben Kanjibhai Shah Medical Institute and Research Centre), Dhiraj general hospital, Vadodara, Gujarat, 200 patients who required induction of labour were recruited after applying inclusion and exclusion criteria and were randomly divided in two groups- Group A meant to receive 50µg oral misoprostol, Group B - meant to receive 25µg vaginal misoprostol repeated 4 hourly up to maximum of five doses. Progress of labour was charted on the partograph. The mean induction delivery interval, mode of delivery, maternal and neonatal outcomes and complications were observed.Results: The mean induction to delivery interval was significantly less in vaginal group than oral (23.3±12.4 hours in oral vs. 17.3±10 hours in vaginal). Vaginal delivery and cesarean section rates were comparable in both groups (76% in Group A vs. 72% in Group B for vaginal delivery, 18% vs. 20% for Cesarean section, respectively). 58% patients in Group A required more than two doses as compared to 39% in group B, though the difference was statistically not significant. Significant number of patients required added oxytocin administration in Group A (72%). No major complications or adverse events were observed. Neonatal hyperbilirubinemia was seen more in Group A.Conclusions: Both Oral misoprostol in a dose of 50μg and vaginal misoprostol 25 μg every four hours, to a maximum of five doses, have the potential to induce labour safely and effectively. The vaginal route however is beneficial in effecting delivery in lesser time with few numbers of doses as compared to oral route.


2018 ◽  
Vol 17 (3) ◽  
pp. 65-72
Author(s):  
Lambros Mpoltsis ◽  
Emmanuel Stamatakis ◽  
Theodoros Xanthos ◽  
Nicoletta Iacovidou ◽  
Athanasios Chalkias ◽  
...  

Background. The 2015 European Resuscitation Council (ERC) Guidelines for Resuscitation and support of transition of babies at birth stress the importance of adequate preparation by the healthcare professionals who are going to receive the newborn immediately after birth in order to avoid preventable neonate deterioration. Midwives and pediatricians are the healthcare professionals in the frontline of neonate reception. Methods. Based on the 2015 ERC guidelines we created a 9-item checklist of indispensable actions for correct preparation for neonate reception after vaginal delivery or cesarean section. 78 midwives and 39 pediatricians were included in this prospective observational study. The impact of prior neonate life support training (NLS) on their performance was also assessed. Results. Regarding preparation for neonate reception, participants performed significantly better when the neonate was delivered by vaginal delivery (mean score 7.21±1.77 vs 5.45±1.55 for cesarean section, p<0.0005). Furthermore, midwives performed significantly better (performance score 6.88±1.87) than pediatricians even when subgroup analysis was performed for residents (5.40±1.59, p=0.002) and consultants (5.46±1.47, p=0.002). Previous NLS training resulted in significantly higher performance scores (6.57±1.81 vs 5.18±1.91 for no NLS training, p=0.004). Conclusions. In the present study midwives performed better than consultant and resident pediatricians in preparing for receiving a neonate immediately after birth and neonatal life support training led to significantly better performance when compared to particiants with no prior NLS training. To our knowledge, this is the first study to assess these skills in midwives and pediatricians.


2021 ◽  
Vol 8 ◽  
pp. 2333794X2110183
Author(s):  
Maleda Tefera ◽  
Nega Assefa ◽  
Kedir Teji Roba ◽  
Letta Gedefa

The adverse neonatal outcome is defined as the presence of birth asphyxia, respiratory distress, birth trauma, hypothermia, meconium aspiration syndrome, neonatal intensive care admission, and neonatal death. It is a major concern in developing countries, including Ethiopia. This study tried to identify predictors of adverse neonatal outcomes at selected public hospitals in Eastern Ethiopia. A hospital-based prospective follow-up study was conducted in three public hospitals in Eastern Ethiopia from June to October 2020. A total of 2,246 laboring women and neonates born at the hospitals were enrolled in the study. Data were collected through interviews, observation checklists, and clinical chart review. Reports were presented in relative risks with 95% CIs. The overall magnitude of adverse neonatal outcome was 20.97% (95% CI: 19.33- 22.71%). It was 24.3% for babies born through cesarean section (95% CI: 21.3%, 27.5). The presence of meconium in the amniotic fluid increased the risk for neonates delivered via cesarean section (ARR, 1.52 95% CI; 1.04, 2.22). Among neonates born via vaginal delivery, the risk of adverse neonatal outcome was higher among nullipara women (ARR, 1.42 95% CI; 1.02, 1.99) and among women diagnosed with abnormal labor or pregnancy such as APH, pre-eclampsia, obstructed labor, fetal distress, and mal-presentation at admission (ARR, 1.30 95%CI; 1.01, 1.67). The risk of adverse neonatal outcome was higher among babies born through the cesarian section than those born via vaginal delivery. Abnormal labor or pregnancy and being primiparous increased the risk of adverse neonatal outcome in vaginal delivery.


2013 ◽  
Vol 6 ◽  
pp. CCRep.S12771 ◽  
Author(s):  
Shameema A. Sadath ◽  
Fathiya I. Abo Diba ◽  
Surendra Nayak ◽  
Iman Al Shamali ◽  
Michael F. Diejomaoh

Introduction Vernix caseosa peritonitis (VCP) is a very unusual complication caused by inflammatory response to amniotic fluid spilled into the maternal peritoneal cavity. Twenty-seven cases have been reported, and all occurred after cesarean section. Case presentation We present a case of VCP following vaginal delivery; this may be the first case reported after vaginal delivery. Mrs. A, 28 years old, gravida 3, para 2, with one previous cesarean section, was admitted at 41 weeks gestation in active labor. Vacuum extraction was performed to deliver a healthy male baby, 4.410 kg, Apgar scores 7, 8. She developed fever, acute abdominal pain, and distension about 3 hours after delivery. A diagnosis of acute abdomen was made. Laparotomy was performed and it revealed neither uterine scar rupture nor other surgical emergencies, but 500 mL of turbid fluid and some cheesy material on the serosal surface of all viscera. Biopsies were taken. She had a course of antibiotics and her recovery was complete. Histology of the peritoneal fluid and tissue biopsy resulted in a diagnosis of VCP. Conclusion Clinical diagnosis of peritonitis due to vernix caseosa should be considered in patients presenting postpartum with an acute abdomen after vaginal delivery.


1974 ◽  
Vol 6 (4) ◽  
pp. 281-288 ◽  
Author(s):  
John R.G. Challis ◽  
Rapin Osathanondh ◽  
Kenneth J. Ryan ◽  
Dan Tulchinsky

2016 ◽  
Vol 11 (6) ◽  
pp. 305-308 ◽  
Author(s):  
Mohammad Heidarzadeh ◽  
Sevil Hakimi ◽  
Abbas Habibelahi ◽  
Marzieh Mohammadi ◽  
Shakiba Pourasad Shahrak

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