Intestinal Behçet’s Disease with Primary Myelofibrosis Involving Trisomy 8

2019 ◽  
Vol 142 (4) ◽  
pp. 253-256 ◽  
Author(s):  
Taisuke Narazaki ◽  
Motoaki Shiratsuchi ◽  
Mariko Tsuda ◽  
Yasuhiro Tsukamoto ◽  
Hiroki Muta ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Intestinal Perforation ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Primary Myelofibrosis ◽  
Trisomy 8 ◽  
Behcet's Disease ◽  
Multiple Organs ◽  
Aphthous Ulcers ◽  
Old Japanese

Behçet’s disease (BD) is a disorder characterized by systemic inflammation of multiple organs, including the intestines. Several studies have reported a relationship between myelodysplastic syndrome and BD, and trisomy 8 was frequently seen, especially in intestinal BD. However, the association of BD with primary myelofibrosis (PMF) has not been well documented. A 58-year-old Japanese female was diagnosed with PMF in 2014. The symptoms of PMF resolved with ruxolitinib. However, she developed fever and intestinal perforation due to multiple ulcers in the terminal ileum in 2017. Intestinal perforation recurred 1 month later, and the dose of ruxolitinib was tapered. After discontinuation of ruxolitinib, she presented with recurrent oral aphthous ulcers and uveitis. Subsequently, intestinal perforation recurred, and she was diagnosed with intestinal BD. Trisomy 8 was identified in her peripheral blood. She underwent steroid therapy, azathioprine, and infliximab. This case suggests relationships between PMF, trisomy 8, and BD.

scholarly journals HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications

Viruses ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 511 ◽  
Author(s):  
S. Islam ◽  
Seonghyang Sohn
Keyword(s):  
Animal Model ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Therapeutic Applications ◽  
Therapeutic Modalities ◽  
Multiple Organs ◽  
Aphthous Ulcers ◽  
Simplex Virus

Behçet’s disease (BD) affects multiple organs. It is mainly characterized by recurrent oral, skin, and genital aphthous ulcers, and eye involvement. Successful management of BD is increasing, although its etiology remains unclear. A number of etiologies have been proposed, including environmental, genetic, viral, and immunological factors. To understand its complex etiology and improve its management, animal models of BD have been used to enable more effective therapeutic applications with increased clinical significance. An herpes simplex virus (HSV) type 1-induced BD mouse model has shown disease characteristics similar to those seen in BD patients. An HSV-induced BD animal model has been used to test various therapeutic modalities. The applied modalities are several materials that are derived from natural products, conventional therapeutics, and possible biologics. In this review, we provided how they regulate inflammation in an HSV-induced BD model.

scholarly journals A case of Behcet's disease associated with myelodysplastic syndrome involving trisomy 8 and a gain-of-function mutation in SHP-2

Rheumatology ◽  
2011 ◽  
Vol 50 (7) ◽  
pp. 1342-1344 ◽  
Author(s):  
T. Shigemura ◽  
K. Agematsu ◽  
T. Yamazaki ◽  
K. Sakashita ◽  
Y. Nakayama ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Trisomy 8 ◽  
Gain Of Function ◽  
Behcet's Disease

scholarly journals Bilateral Neuroretinitis and a Unilateral Superior Hemivein Occlusion with Frosted Branch Angiitis Pattern Presenting Simultaneously in Behçet's Disease

2016 ◽  
Vol 7 (1) ◽  
pp. 141-147 ◽  
Author(s):  
Roy Schwartz ◽  
Sara Borok ◽  
Michaella Goldstein ◽  
Anat Kesler ◽  
Keren Regev ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Erythema Nodosum ◽  
Behçet's Disease ◽  
Clinical Manifestations ◽  
Unique Case ◽  
Behcet's Disease ◽  
Frosted Branch Angiitis ◽  
Ocular Manifestations ◽  
Aphthous Ulcers

Purpose: To report a unique case of Behçet's disease that presented with atypical ocular manifestations. Methods: Case report. Results: A 23-year-old homosexual male presented with bilateral anterior uveitis, vitritis, neuroretinitis and a unilateral superior hemivein occlusion with frosted branch angiitis pattern. These were accompanied by systemic findings of recurrent oral aphthous ulcers, erythema nodosum, and neurological and gastrointestinal involvement. A positive HLA-B51 examination supported the diagnosis of Behçet's disease. Conclusion: Neuroretinitis and frosted branch angiitis may be the clinical manifestations of Behçet's disease and may present simultaneously.

scholarly journals Clinical Effect of Non-Thermal CO2 Laser Therapy (NTCLT) on Pain Relief of Oral Aphthous Ulcers of Behçet’s Disease

2021 ◽  
Vol 12 (1) ◽  
pp. e72-e72
Author(s):  
Nasrin Zand ◽  
Leila Ataie-Fashtami ◽  
Parvin Mansouri ◽  
Mohsen Fateh ◽  
Afshan Shirkavand
Keyword(s):  
Pain Relief ◽  
Adverse Effects ◽  
Laser Therapy ◽  
Behçet’S Disease ◽  
Co2 Laser ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Oral Ulcers ◽  
Aphthous Ulcers

Introduction: Behçet’s disease (BD) is a debilitating and chronic vasculitis which can affect multiple organs. Recurrent oral aphthosis is the most common clinical feature of BD. The remarkable pain associated with painful oral ulcers can exert a major impact on the patients’ quality of life. Relieving pain of these oral ulcers is an essential approach in the management of mucocutaneous lesions of BD. Non-thermal CO2 laser therapy (NTCLT) as a novel photobiomodulative approach has recently been used for significant and immediate pain reduction of some types of painful oral lesions such as recurrent aphthous stomatitis, pemphigus vulgaris, and so on. In this procedure by some considerations, the conventional CO2 laser is used as a non-surgical, non- thermal, photobiomodulative laser without any visible thermal adverse effects. In this article, we report our experiences about the analgesic effects of NTCLT on painful oral aphthous ulcers of BD. Case Presentation: We report four cases of BD, whose painful oral aphthous ulcers were irradiated with NTCLT. Immediately after NTCLT, the pain of the lesions was significantly relieved with no visible complications. Conclusion: The results of this study suggest that NTCLT could be proposed as a hopeful procedure for significant and instant pain relief of oral aphthous ulcers of BD without any visible thermal adverse effects.

scholarly journals Trisomy 8-Associated Intestinal Behcet’s Disease That Achieved Complete Remission With Mesalazine

2018 ◽  
Vol 9 (8) ◽  
pp. 255-259
Author(s):  
Satoshi Tanida ◽  
Keiji Ozeki ◽  
Tsutomu Mizoshita ◽  
Mamoru Tanika ◽  
Hirotada Nishie ◽  
...  
Keyword(s):  
Complete Remission ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Trisomy 8 ◽  
Intestinal Behçet’S Disease ◽  
Behcet's Disease ◽  
Intestinal Behcet’S Disease ◽  
Intestinal Behçet's Disease
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