scholarly journals Nonalcoholic Fatty Pancreas Disease: Clinical Consequences

2019 ◽  
Vol 38 (Suppl. 2) ◽  
pp. 143-149 ◽  
Author(s):  
Petr Dite ◽  
Martin Blaho ◽  
Martina Bojkova ◽  
Petr Jabandziev ◽  
Lumir Kunovsky
Keyword(s):  
Metabolic Syndrome ◽  
Adult Population ◽  
Developed Countries ◽  
Sonographic Examination ◽  
Pancreas Disease ◽  
Pancreatic Fat ◽  
Important Relationship ◽  
Fatty Pancreas ◽  
Clinical Consequences ◽  
Pancreatic Steatosis

Metabolic syndrome and its components such as obesity, hypertriglyceridemia, type-2 diabetes mellitus (DM-T2), and arterial hypertension are unequivocally serious problems for every society. This is especially true in economically developed countries where the imbalance in lifestyle between caloric intake and caloric output still gets greater and greater. This fact is not only a concern for the adult population but for children as well. However, metabolic syndrome does not only affect society and health in regards to cardiovascular diseases, it significantly concerns gastroenterology where it is classified as nonalcoholic fatty pancreas disease (NAFPD). The data gained from several trials show that the prevalence of NAFDP is 33% (95% CI 24–41%). When it comes to the diagnostic procedures concerning the presence of pancreatic fat, a whole spectrum of suitable methods are recommended. Probably, the most exact method is the use of magnetic resonance imaging. However, for common clinical practice, the abdominal sonographic examination based on the comparison of the pancreatic parenchymatous echogenity versus renal or hepatic echogenity is used. The clinical consequences of pancreatic steatosis and steatopancreatitis are significant. These diseases are connected with DM-T2 and insulin resistance. In recent years, changes of exocrine pancreatic function, particularly its decrease, have also been described. It is known that there is a close correlation between NAFPD and nonalcoholic hepatic steatosis and also with the increased thickness of aortic intima-media. There is also an important relationship between NAFPD and pancreatic carcinoma. Pancreatic steatosis, and especially its NAFPD form, is a serious state which can be treatable by the possible effective management of metabolic syndrome parameters, including obesity.

scholarly journals Non-alcoholic fatty pancreas disease – practices for clinicians

2019 ◽  
Vol 57 (3) ◽  
pp. 209-219 ◽  
Author(s):  
Larisa Pinte ◽  
Daniel Vasile Balaban ◽  
Cristian Băicuş ◽  
Mariana Jinga
Keyword(s):  
Metabolic Syndrome ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Diagnostic Evaluation ◽  
Pancreas Disease ◽  
Alcoholic Fatty Liver ◽  
The Metabolic Syndrome ◽  
Fatty Pancreas ◽  
Alcoholic Fatty Liver Disease

Abstract Obesity is a growing health burden worldwide, increasing the risk for several diseases featuring the metabolic syndrome – type 2 diabetes mellitus, dyslipidemia, non-alcoholic fatty liver disease and cardiovascular diseases. With the increasing epidemic of obesity, a new pathologic condition has emerged as a component of the metabolic syndrome – that of non-alcoholic fatty pancreas disease (NAFPD). Similar to non-alcoholic fatty liver disease (NAFLD), NAFPD comprises a wide spectrum of disease – from deposition of fat in the pancreas – fatty pancreas, to pancreatic inflammation and possibly pancreatic fibrosis. In contrast with NAFLD, diagnostic evaluation of NAFPD is less standardized, consisting mostly in imaging methods. Also the natural evolution of NAFPD and its association with pancreatic cancer is much less studied. Not least, the clinical consequences of NAFPD remain largely presumptions and knowledge about its metabolic impact is limited. This review will cover epidemiology, pathogenesis, diagnostic evaluation tools and treatment options for NAFPD, with focus on practices for clinicians.

scholarly journals Influence of pancreatic steatosis severity on the course of pediatric nonalcoholic fatty pancreas disease

2017 ◽  
Vol 12 (6) ◽  
pp. 670-676
Author(s):  
Yu.M. Stepanov ◽  
O.Yu. Lukianenko ◽  
N.Yu. Zavhorodnia ◽  
N.H. Hravyrovska
Keyword(s):  
Pancreas Disease ◽  
Fatty Pancreas ◽  
Pancreatic Steatosis

Metabolic syndrome and non-alcoholic fatty pancreas disease (NAFPD)

Pancreatology ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. S108
Author(s):  
Martin Blaho ◽  
Petr Dítě
Keyword(s):  
Metabolic Syndrome ◽  
Pancreas Disease ◽  
Fatty Pancreas

scholarly journals Exploring the metabolic syndrome: Nonalcoholic fatty pancreas disease

2016 ◽  
Vol 22 (34) ◽  
pp. 7660 ◽  
Author(s):  
Roberto Catanzaro ◽  
Biagio Cuffari ◽  
Angelo Italia ◽  
Francesco Marotta
Keyword(s):  
Metabolic Syndrome ◽  
Pancreas Disease ◽  
The Metabolic Syndrome ◽  
Fatty Pancreas

Fatty pancreas in relation to insulin resistance and metabolic syndrome in children with obesity

2019 ◽  
Vol 32 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Marwa Elhady ◽  
Amira Aly Ahmed Mahmoud Elazab ◽  
Karima Abdelfattah Bahagat ◽  
Naglaa Abdelmoneam Abdallah ◽  
Gamil El-Sayed Ibrahim
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Visceral Fat ◽  
Control Group ◽  
Model Assessment ◽  
Obese Children ◽  
Pancreatic Fat ◽  
Fatty Pancreas ◽  
Lean Children ◽  
Age And Sex

Abstract Background Ectopic visceral fat is a major risk factor for obesity complications including insulin resistance and metabolic syndrome. Ultrasonography is a simple bedside screening tool used for the assessment of ectopic visceral fat including fatty pancreas. This study investigates the association between insulin resistance, metabolic syndrome and fatty pancreas detected by ultrasound in children with obesity. Methods This case-control study included 50 prepubertal obese (body mass index [BMI] ≥95th age- and sex-specific percentiles) and 30 lean children (BMI 5th–85th age- and sex-specific percentiles) as the control group. Clinical and laboratory parameters of metabolic syndrome including anthropometric indices of central obesity, blood pressure, fasting glucose and lipid profile were measured. Homeostasis model assessment-insulin resistance (HOMA-IR) was used to assess insulin resistance. Ultrasonographic assessment for pancreatic fat was done for all children. Results Fifty-eight percent of obese children had fatty pancreas. Obese children with fatty pancreas had a higher rate of metabolic syndrome (p=0.013) and insulin resistance than those with non-fatty pancreas (p=0.012). Regression analysis revealed that fatty pancreas is an independent predictor of metabolic syndrome and insulin resistance. Fatty pancreas increases the risk for metabolic syndrome (odds ratio [OR] 11.40; 95% confidence interval [CI]: 2.69–48.22) and insulin resistance (OR 7.85; 95% CI: 2.20–28.05) in children with obesity. Conclusions Obese children have higher pancreatic fat accumulation than lean children. Obese children with fatty pancreas are more susceptible to insulin resistance and metabolic syndrome.

scholarly journals A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High Fat Diet

2010 ◽  
Vol 46 (3) ◽  
pp. 212-223 ◽  
Author(s):  
Julio C. Fraulob ◽  
Rebeca Ogg-Diamantino ◽  
Caroline Fernandes-Santos ◽  
Marcia Barbosa Aguila ◽  
Carlos A. Mandarim-de-Lacerda
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Mouse Model ◽  
Fatty Liver ◽  
High Fat Diet ◽  
High Fat ◽  
Pancreas Disease ◽  
Fatty Pancreas

The Worrying Trend of Diabetes Mellitus in Saudi Arabia: An Urgent Call to Action

2020 ◽  
Vol 16 (3) ◽  
pp. 204-210 ◽  
Author(s):  
Asirvatham A. Robert ◽  
Mohamed A. Al Dawish
Keyword(s):  
Diabetes Mellitus ◽  
Saudi Arabia ◽  
Present Report ◽  
Adult Population ◽  
Current Trend ◽  
Fold Increase ◽  
Developed Countries ◽  
Evidence Base ◽  
Small Sample ◽  
Cross Sectional

From last few years, the pervasiveness of diabetes mellitus (DM), in Saudi Arabia, is growing at a frightening rate. Overall, one-fourth of the adult population is affected by DM, which is further predicted to rise to more than double by the year 2030. The most alarming is possibly the escalation propensity of diabetes, in recent years, where a nearly ten-fold increase has been witnessed over the past thirty years in Saudi Arabia. However, the number of research arbitrations on the prevalence and incidence of DM is woefully inadequate, as compared to developed countries. Apart from this, most of the existing research data carried out in Saudi Arabia is cross-sectional, with small sample sizes, which most often involve only certain parts of the country. Consequently, the present scenario demands more multidimensional and multisectoral research to strengthen the evidence base and to accumulate greater knowledge as a basis for measures and programmes to confront diabetes and its complications. Thus, the present report makes an attempt to depict the current trend of diabetes as well as intends to put forward essential measures for controlling diabetes in Saudi Arabia.

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