scholarly journals Primary Melanoma of the Lung Treated with Surgery, Dabrafenib and Trametinib

2020 ◽  
Vol 13 (2) ◽  
pp. 789-792
Author(s):  
Layla G. Landgraf ◽  
Mark A. Malias ◽  
Stephen J. Patterson
Keyword(s):  
Malignant Melanoma ◽  
Wedge Resection ◽  
Lung Nodule ◽  
Primary Melanoma ◽  
Molecular Testing ◽  
Ct Guided ◽  
Dna Mutation ◽  
Tumor Specimen ◽  
Atypical Cells ◽  
Full Body

This is a case report on a 69-year-old woman who was diagnosed with malignant melanoma presenting in the lung. A complete staging workup was performed by her oncologist, with no skin lesion identified as a primary. CT-guided needle biopsy of the lung nodule was completed, with pathology revealing atypical cells consistent with malignant melanoma. Following full body examination by the cutaneous oncologist, a robotic wedge resection and lymph node dissection accompanied by bronchoscopy were performed. Molecular testing (Caris Life Sciences) of the surgical tumor specimen revealed pathological BRAF DNA mutation in exon 15/p.V600K. The patient was initially treated with nivolumab, then treated with a combination of dabrafenib and trametinib at recurrence.

scholarly journals Methylene Blue versus Coil-Based Computed Tomography-Guided Localization of Lung Nodules

2020 ◽  
Vol 68 (06) ◽  
pp. 540-544 ◽  
Author(s):  
Ze-Dong Zhang ◽  
Hua-Long Wang ◽  
Xian-Yan Liu ◽  
Feng-Fei Xia ◽  
Yu-Fei Fu
Keyword(s):  
Computed Tomography ◽  
Methylene Blue ◽  
Thoracoscopic Surgery ◽  
Wedge Resection ◽  
Lung Nodule ◽  
Lung Nodules ◽  
Complication Rates ◽  
Success Rates ◽  
Technical Success ◽  
Ct Guided

Abstract Background Preoperative computed tomography (CT)-guided localization has been shown to significantly improve lung nodule video-assisted thoracoscopic surgery (VATS)-based wedge resection technical success rates. However, at present, there was insufficient research regarding the optimal approaches to localization of these nodules prior to resection. We aimed to compare the relative clinical efficacy of preoperative CT-guided methylene blue and coil-based lung nodule localization. Methods In total, 91 patients with lung nodules were subjected to either CT-guided methylene blue (n = 34) or coil (n = 57) localization and VATS resection from January 2014 to December 2018. We compared baseline data, localization-associated complication rates, as well as the technical success of localization and resection between these two groups of patients. Results In total, 42 lung nodules in 34 patients underwent methylene blue localization, with associated localization and wedge resection technical success rates of 97.6 and 97.6%, respectively. A total of 71 lung nodules in 57 patients underwent coil localization, with associated localization and wedge resection technical success rates of 94.4 and 97.2%, respectively. There were no significant differences in technical success rates of localization or wedge resection between these groups (p = 0.416 and 1.000, respectively). The coil group sustained a longer duration between localization and VATS relative to the methylene blue group (13.2 vs. 2.5 hours, p = 0.003). Conclusion Both methylene blue and coil localization can be safely and effectively implemented for conducting the diagnostic wedge resection of lung nodules. The coil-based approach is compatible with a longer period of time between localization and VATS procedures.

scholarly journals Late Lung Metastasis in a Patient with a Clear Cell Chondrosarcoma: An Indication for a Life-Long Follow-Up?

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Paulien West ◽  
Celine Jacobs ◽  
Michael Saerens ◽  
David Creytens ◽  
Gwen Sys ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Clear Cell ◽  
Wedge Resection ◽  
Lung Nodule ◽  
Complete Removal ◽  
Good Health ◽  
Ct Guided ◽  
Clear Cell Chondrosarcoma ◽  
Lung Lobe

Background. Clear cell chondrosarcoma (CCCS) is a rare subtype of chondrosarcoma and comprises between 1.6% and 2.5% of all chondrosarcoma. They are known to be chemo- and radiotherapy resistant; surgical resection is therefore the therapy of choice. Methods. We present a 63-year-old woman with a progressive lung nodule 20 years after initial diagnosis and treatment of a clear cell chondrosarcoma of the right os naviculare. Results. On serial CT scans of the chest, an asymptomatic, slowly growing nodule in the left upper lung lobe was detected. CT-guided transthoracic biopsy of this nodule confirmed the diagnosis of a chondrosarcoma lung metastasis. Video-assisted thoracoscopic wedge resection was performed with complete removal of the nodule. The patient recovered well from surgery and remains in good health during further follow-up. Conclusion. Given the tendency of clear cell chondrosarcoma to recur and metastasize after extended periods of time, a long-term, possibly life-long follow-up and clinical surveillance is advisable in these patients.

scholarly journals NCCN Guidelines® Insights: Melanoma: Cutaneous, Version 2.2021

2021 ◽  
Vol 19 (4) ◽  
pp. 364-376
Author(s):  
Susan M. Swetter ◽  
John A. Thompson ◽  
Mark R. Albertini ◽  
Christopher A. Barker ◽  
Joel Baumgartner ◽  
...  
Keyword(s):  
Lymph Node ◽  
Systemic Therapy ◽  
Advanced Disease ◽  
Primary Melanoma ◽  
Lymph Node Biopsy ◽  
Molecular Testing ◽  
Nccn Guidelines ◽  
Therapeutic Lymph Node Dissection ◽  
The Past ◽  
Node Biopsy

Over the past few years, the NCCN Guidelines for Melanoma: Cutaneous have been expanded to include pathways for treatment of microscopic satellitosis (added in v2.2020), and the following Principles sections: Molecular Testing (added in v2.2019), Systemic Therapy Considerations (added in v2.2020), and Brain Metastases Management (added in v3.2020). The v1.2021 update included additional modifications of these sections and notable revisions to Principles of: Pathology, Surgical Margins for Wide Excision of Primary Melanoma, Sentinel Lymph Node Biopsy, Completion/Therapeutic Lymph Node Dissection, and Radiation Therapy. These NCCN Guidelines Insights discuss the important changes to pathology and surgery recommendations, as well as additions to systemic therapy options for patients with advanced disease.

Ectopic spleen presenting as a slowly enlarging lung nodule in the right lower lobe following gastric pull up operation

2021 ◽  
Vol 14 (2) ◽  
pp. e237912
Author(s):  
Anas Alfahad ◽  
Rima Hussain ◽  
Mamatha Devaraj ◽  
Alexandr Svec
Keyword(s):  
Case Report ◽  
Oesophageal Cancer ◽  
Lung Nodule ◽  
Lower Lobe ◽  
Ct Guided ◽  
Ectopic Spleen ◽  
Guided Biopsy ◽  
Ct Guided Biopsy ◽  
The Right ◽  
Gastric Pull Up

This is a case report of an elderly man who was investigated at our respiratory clinic for slowly enlarging right lower lobe lung nodule on the background of oesophageal cancer diagnosed more than 11 years ago with gastric pull up. CT guided biopsy confirms the diagnosis of intrathoracic ectopic spleen.

scholarly journals Primary Melanoma of the Lung: A Systematic Review

Medicina ◽  
2020 ◽  
Vol 56 (11) ◽  
pp. 576
Author(s):  
Panagiotis Paliogiannis ◽  
Antonella M. Fara ◽  
Gianfranco Pintus ◽  
Wael M. Abdel-Rahman ◽  
Maria Colombino ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Single Case ◽  
Left Lung ◽  
Case Series ◽  
Primary Melanoma ◽  
Primary Malignant Melanoma ◽  
S 100 ◽  
Main Determinants ◽  
Mitotic Figures ◽  
Rare Malignancy

Background and Objectives: The respiratory apparatus, generally affected by highly aggressive tumors like lung cancer and mesothelioma, is rarely affected by primary malignant melanoma. The aim of this review was to identify cases of primary malignant melanoma of the lung (PMML) published in the modern scientific literature, and to describe their main clinical, pathological and therapeutic features. Materials and Methods: A systematic search of publications in the electronic database PubMed has been performed using keywords, and the references of the selected articles were checked to identify additional missing studies. Results: Globally 52 papers reporting on 76 cases were identified. Among them there were 47 reports of a single case, three papers reporting on two cases each, and two larger case series published in 1997 and 2005 including eight and 15 cases, respectively. Conclusions: PMML was generally diagnosed in middle-aged males, without any apparent correlation with cigarette smoking. It was more frequently found in the lower lobes and the left lung. The tumors were generally pigmented, composed by epithelial and/or spindle cells with large nuclei and prominent nucleoli, nuclear atypia, and numerous mitotic figures; they commonly showed immunostaining for S-100, HMB 45 and Melan-A. Early detection and surgical resection were the main determinants of survival from this rare malignancy.

Metastases from Melanoma of Unknown Origin

1969 ◽  
Vol 55 (6) ◽  
pp. 403-408
Author(s):  
Natale Cascinelli ◽  
Silvana Pilotti
Keyword(s):  
Malignant Melanoma ◽  
Lymph Nodes ◽  
Primary Melanoma ◽  
Unknown Origin ◽  
Primary Site

720 cases of malignant melanoma were treated in 30 years at the Cancer Institute of Milan. In 12 of these cases the primary site of the tumor remained unknown: metastases were found 10 times in the lymph nodes, twice in the subcutis, once in the bone (rib). The incidence of occult primary melanoma is 1.6 per cent.

scholarly journals Diagnosis and management of small pulmonary atypical carcinoid tumor associated with Cushing syndrome

2020 ◽  
Vol 9 (4) ◽  
Author(s):  
Dathe Z Benissan-Messan ◽  
Robert E Merritt ◽  
Konstantin Shilo ◽  
Desmond M D'Souza ◽  
Peter J Kneuertz
Keyword(s):  
Carcinoid Tumor ◽  
Adrenocorticotropic Hormone ◽  
Cushing Syndrome ◽  
Wedge Resection ◽  
Lung Nodule ◽  
Pet Scan ◽  
Atypical Carcinoid ◽  
Pulmonary Carcinoid ◽  
Ectopic Adrenocorticotropic Hormone

Ectopic adrenocorticotropic hormone ( ACTH) syndrome is rare and identification of its source is often challenging. We report the case of an ectopic Cushing syndrome in a young adult male secondary to an occult ACTH producing atypical carcinoid tumor. Extensive biochemical and imaging workup was unrevealing. The diagnosis was aided by Ga-DOTA PET scan demonstrating a suspicious left upper lobe lung nodule. The patient underwent video-assisted thoracoscopic exploration with wedge resection and mediastinal lymphadenectomy of a T2aN2M0 atypical carcinoid, resulting in the normalization of ACTH levels and complete resolution of symptoms. The role of a Ga-DOTA PET scan in diagnosing pulmonary carcinoid tumors and their management are discussed.

scholarly journals Metastatic Malignant Melanoma of Parotid Gland with a Regressed Primary Tumor

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
M. Mustafa Kılıçkaya ◽  
Giray Aynali ◽  
Ali Murat Ceyhan ◽  
Metin Çiriş
Keyword(s):  
Malignant Melanoma ◽  
Parotid Gland ◽  
Head And Neck ◽  
Primary Tumor ◽  
Primary Melanoma ◽  
Metastatic Malignant Melanoma ◽  
Malignant Melanomas ◽  
Pigmented Lesions

Malignant melanoma of the parotid gland is often metastatic and mainly originates from malignant melanomas in the head and neck. Nevertheless, some malignant melanomas may metastasize and subsequently regress. Therefore, it may not be possible to observe a metastatic malignant melanoma and its primary melanoma simultaneously. The investigation of a patient’s old photographs may help in the detection of preexisting and regressed pigmented lesions in the facial and neck regions.

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