scholarly journals Anterior Mediastinal Leiomyosarcoma: A Case Report and Literature Review

2021 ◽  
pp. 101-106
Author(s):  
Akira Ishikawa ◽  
Kazuya Kuraoka ◽  
Junichi Zaitsu ◽  
Akihisa Saito ◽  
Atsushi Kamigaichi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Literature Review ◽  
Tumor Cells ◽  
Growth Pattern ◽  
Mediastinal Mass ◽  
Smooth Muscle Actin ◽  
Anterior Mediastinum ◽  
Anterior Mediastinal Mass ◽  
Muscle Actin

Primary mediastinal sarcomas are extremely rare. Additionally, mediastinal leiomyosarcomas account for approximately 9% of mediastinal sarcoma cases. Until date, only few cases of anterior mediastinal leiomyosarcomas have been reported. Herein, we report a case of an 85-year-old female with an anterior mediastinal mass of 15 mm. Histological examination revealed spindle tumor cells showing a fascicular growth pattern. Immunohistochemically, the tumor cells were focal positive for desmin, calponin, and α-smooth muscle actin. The pathological diagnosis was leiomyosarcoma. In conclusion, we encountered a case of a very rare leiomyosarcoma that occurred in the anterior mediastinum, and our report may contribute to the understanding of this disease.

MESENCHYMAL TUMOR LEIOMYOSARCOMA OF PROSTATE, A RARE CASE REPORT

2021 ◽  
pp. 21-22
Author(s):  
Ekta Rani ◽  
Sarita Nibhoria ◽  
Bikramjit Singh ◽  
Aradhana Singh Hada ◽  
Parminderjeet Singh Sandhu
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Tumor Cells ◽  
Poor Prognosis ◽  
Rare Case ◽  
Smooth Muscle Actin ◽  
Mesenchymal Tumor ◽  
Muscle Actin ◽  
Rare Case Report ◽  
Rare Malignancy

Primary prostate sarcoma is a rare malignancy of the prostate with poor prognosis. It accounts for <1% of the tumors of the prostate. Leiomyosarcoma is the most common sarcoma involving the prostate in adults affecting men between the ages of 40 and 78 years. Tumor cells commonly express vimentin, smooth muscle actin and desmin, and up to 25% express cytokeratins.

scholarly journals Case Report: A giant myopericytoma involving the occipital region of the scalp - a rare entity

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2905 ◽  
Author(s):  
Sunil Munakomi ◽  
Pramod Chaudhary
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Histological Examination ◽  
Rare Case ◽  
Smooth Muscle Actin ◽  
Positive Staining ◽  
Occipital Region ◽  
Rare Entity ◽  
Muscle Actin ◽  
Complete Excision

Herein we report a rare case of a giant myopericytoma presenting in a 16-year-old girl as a slowly progressive swelling involving the scalp in the occipital region. It was managed by complete excision. Histological examination of the lesion revealed  spindle-shaped cells forming characteristic rosettes around the blood vessels, and positive staining with smooth muscle actin.

Basaloid Squamous Cell Carcinoma of the Esophagus With or Without Adenoid Cystic Features

2004 ◽  
Vol 128 (10) ◽  
pp. 1124-1130 ◽  
Author(s):  
Tie-Jun Li ◽  
Yong-Xin Zhang ◽  
Julie Wen ◽  
Daniel F. Cowan ◽  
John Hart ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Smooth Muscle ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Smooth Muscle Actin ◽  
Basaloid Squamous Cell Carcinoma ◽  
Muscle Actin ◽  
Adenoid Cystic ◽  
Basaloid Squamous

Abstract Context.—Basaloid squamous cell carcinoma (BSCC) of the esophagus is a rare malignant tumor that morphologically could bear some resemblance to adenoid cystic carcinoma (ACC) originating from salivary glands. Objective.—The purpose of this study is to describe the histologic, immunohistochemical, and ultrastructural findings of BSCCs of the esophagus, with an emphasis on comparing tumors with or without adenoid cystic features. Design.—We reviewed 239 cases of primary esophageal carcinoma and detected 12 cases (5%) of BSCC. The light and electron microscopic findings and immunocytochemical localization of various antigens, including cytokeratins (AE1, AE3), carcinoembryonic antigen, epithelial membrane antigen, S100, smooth muscle actin, and p53, were examined in these BSCC cases. Results.—Histologically, all BSCCs were composed of solid lobules or nests of basaloid cells with well-demarcated outlines surrounded by a fibrous stroma. Seven of 12 tumors showed areas of ACC-like features, that is, cribriform-like pseudoglandular lumina formation and hyaline material surrounding the tumor nests, whereas the remaining 5 tumors were apparently pure basaloid carcinomas. These 2 groups of tumors were histologically and immunohistochemically identical in many aspects, namely, high-grade nuclei of the tumor cells with frequent mitoses, abundant comedo-type necrosis, focal areas of concomitant squamous differentiation, consistent immunoreactivity for cytokeratins, and poor or absent staining for S100 and smooth muscle actin. Ultrastructurally, the basaloid tumor cells exhibited relatively undifferentiated cellular characteristics and undeveloped cell organelles. Conclusion.—Basaloid squamous cell carcinomas of the esophagus frequently have an intimate association with ACC-like patterns, but their histologic, immunocytochemical, and ultrastructural features correspond more to poorly differentiated squamous cell carcinoma than to salivary gland ACC. This distinction is important because genuine ACC is much less aggressive than BSCC.

scholarly journals Cutaneous myofibroblastic fibrosarcoma in a margay (Leopardus wiedii): a case report

2020 ◽  
Vol 13 (3) ◽  
pp. 597-601
Author(s):  
Raúl Bermúdez-Salas ◽  
Natalia Campos ◽  
Daniel Barrantes ◽  
Randall Arguedas ◽  
Alejandro Alfaro-Alarcón
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Smooth Muscle Actin ◽  
Histopathological Analysis ◽  
Muscle Actin ◽  
First Report ◽  
Mesenchymal Neoplasm

A routine check-up was performed on a captive 14-year-old female margay (Leopardus wiedii), a cutaneous mass was detected on the ventral thorax. The mass was surgically removed and sent for histopathological analysis. Histologically, the mass was a poorly-demarcated, highly cellular, infiltrative and unencapsulated mesenchymal neoplasm. Immunohistochemical labeling for smooth muscle actin and vimentin were positive, while desmin and cytokeratin were negative which is consistent with a myofibroblastic fibrosarcoma. This type of tumor has been diagnosed in wild felines, however this seems to be the first report of its occurrence in this L. wiedii. Wildlife oncology studies should be performed to promote our understanding of cancer in a species.

scholarly journals Congenital Cutaneous Kaposiform Hemangioendothelioma in a Newborn Calf

2020 ◽  
Vol 43 (2) ◽  
pp. 193-196
Author(s):  
Erkmen Tuğrul Epikmen ◽  
Ahmet Aydogan ◽  
Hamdi Avci ◽  
Sümbül Serap Birincioğlu
Keyword(s):  
Endothelial Cells ◽  
Smooth Muscle ◽  
Tumor Cells ◽  
Histopathological Examination ◽  
Smooth Muscle Actin ◽  
Whole Body ◽  
Muscle Actin ◽  
Alpha Smooth Muscle Actin ◽  
Kaposiform Hemangioendothelioma ◽  
The Masses

AbstractA one-day-old female Holstein calf was presented with subcutaneous masses spread over the whole body. Macroscopically, the masses were firm in touch, greyish-white in colour, 0.5-2 cm in diameter range. Histopathological examination confirmed the cutaneous Kaposiform hemangioendothelioma (KHE). Microscopic examination of the tumor revealed sheets of spindled endothelial cells forming vascular slits. Immunohistochemically, the tumor cells and capillaries gave strongly positive reaction for CD31 while vimentin, alpha smooth muscle actin and cytokeratin AE1/AE3 were negative. In this case, macroscopical, detailed histhopathological and immunohistochemical findings of congenital KHE reported firstly in a newborn calf.

Malignant Solitary Fibrous Tumor of the Pleura With Liposarcomatous Differentiation

2001 ◽  
Vol 125 (3) ◽  
pp. 406-409
Author(s):  
Hongwei Bai ◽  
Bassam I. Aswad ◽  
Henning Gaissert ◽  
Douglas R. Gnepp
Keyword(s):  
Smooth Muscle ◽  
Tumor Cells ◽  
Solitary Fibrous Tumor ◽  
Smooth Muscle Actin ◽  
Mitotic Rate ◽  
Muscle Actin ◽  
Solitary Fibrous Tumors ◽  
Collagenous Stroma ◽  
Well Differentiated ◽  
Fibrous Tumor

Abstract Pleural solitary fibrous tumors (SFTs) are uncommon tumors. Although these tumors have been well characterized, malignant pleural SFTs with liposarcomatous differentiation have not been reported. We report an unusual malignant pleural SFT intermixed with foci of well-differentiated liposarcoma. The patient was a 66-year-old, white man with a large, solid right pleural mass that measured 13.5 × 10.3 × 8.5 cm. The tumor was composed of spindle-shaped and plump cells embedded in dense collagenous stroma. The tumor cells were arranged in interlacing fascicles or in a patternless pattern. Marked nuclear atypia, a high mitotic rate (21 mitoses per 10 high-power fields), and areas of prominent necrosis were evident. In addition, numerous adipocytes mixed with typical lipoblasts were seen scattered throughout portions of the tumor. Immunohistochemistry revealed the tumor cells were strongly positive for CD34 and vimentin and negative for cytokeratin, desmin, smooth muscle actin (IA4), and S100. To the best of our knowledge, this case represents the first example of a malignant SFT with liposarcomatous differentiation.

Renal Myopericytoma: Case Report and Review of Literature

2012 ◽  
Vol 136 (5) ◽  
pp. 563-566 ◽  
Author(s):  
Sadhna Dhingra ◽  
Alberto Ayala ◽  
Hong Chai ◽  
Vanessa Moreno ◽  
Bihong Zhao
Keyword(s):  
Smooth Muscle ◽  
Case Report ◽  
Renal Mass ◽  
Smooth Muscle Actin ◽  
Muscle Actin ◽  
Review Of Literature ◽  
Computed Tomography Scan ◽  
Muscle Myosin ◽  
Cd34 Expression ◽  
Tomography Scan

Myopericytoma arising in the visceral organs is rare and only 1 case of renal myopericytoma has been reported in the literature to date. We report the second case of myopericytoma arising in the kidney in a 40-year-old Hispanic woman who presented with pain on the left side of the abdomen and frequent urination. Abdominal computed tomography scan showed an exophytic left-sided renal mass. Partial nephrectomy was performed. The patient remains free of disease at 24 months after diagnosis. Our case is histologically distinct from the previously described case as it lacks the “hemangiopericytic/glomangiopericytoma” pattern. The tumor in our case showed the characteristic pattern of myopericytoma and an additional glomus tumorlike pattern. The tumor cells showed diffuse reactivity for vimentin, smooth muscle actin, smooth muscle myosin heavy chain, and muscle-specific actin in both morphologic patterns and strong diffuse CD34 expression in glomus tumorlike focus. This case report adds to the morphologic heterogeneity of myopericytomas.

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