Quality of Life Is Associated with Cardiac Biomarkers, Echocardiographic Indices, and Mortality in CKD Stage 4–5 Patients Not on Dialysis

2020 ◽  
pp. 1-8
Author(s):  
Markus Hakamäki ◽  
Roosa Lankinen ◽  
Tapio Hellman ◽  
Niina Koivuviita ◽  
Jussi P. Pärkkä ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Troponin T ◽  
Short Form ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Cardiac Biomarkers ◽  
Stage 4 ◽  
Ckd Stage

<b><i>Introduction:</i></b> Patients with CKD have an impaired health-related quality of life (QoL). Most studies have been conducted on dialysis patients, and less is known about QoL and its determinants in predialysis patients. We studied the association between QoL and comorbidities, cardiac biomarkers, echocardiography, and mortality in patients with CKD stage 4–5 not on dialysis. <b><i>Methods:</i></b> A total of 140 patients enrolled in the Chronic Arterial Disease, Quality of Life and Mortality in Chronic Kidney Injury (CADKID) study filled the Kidney Disease Quality of Life Short Form (KDQOL-SF) at the beginning of the study. Echocardiography and biochemical parameters were obtained at baseline. Patients were followed up for at least 2 years or until death. <b><i>Results:</i></b> The median age was 66 years, and 51 (36%) patients were female. The median estimated glomerular filtration rate was 13 mL/min per 1.73 m<sup>2</sup>. Obesity, diabetes, atrial fibrillation, and congestive heart failure were associated with lower QoL scores in multiple KDQOL-SF domains. Cardiac biomarkers, troponin T (<i>p</i> = 0.02), N-terminal pro-B-type natriuretic peptide (<i>p</i> = 0.006), and the echocardiographic parameter of cardiac systolic function left ventricular global longitudinal strain (<i>p</i> = 0.02) were significant predictors of lower physical component summary (PCS) score in multivariable regression models after controlling for age, BMI, and diabetes. A low PCS score predicted mortality in a multivariable Cox proportional hazards model [HR 0.96 (95% CI 0.92–0.99), <i>p</i> = 0.03]. QoL was not associated with kidney disease progression. <b><i>Conclusion:</i></b> Impaired QoL in CKD stage 4–5 patients not on dialysis is associated with cardiac biomarker levels, echocardiographic indices, and mortality.

scholarly journals Maximal Stress Ergometry Performance is Associated with Troponin T and Abdominal Aortic Calcification Score in Severe Chronic Kidney Disease

2020 ◽  
Author(s):  
Roosa Lankinen ◽  
Markus Hakamäki ◽  
Kaj Metsärinne ◽  
Niina S Koivuviita ◽  
Jussi P Pärkkä ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Troponin T ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Aortic Calcification ◽  
Cardiac Biomarkers ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic ◽  
Calcification Score

Abstract Background Cardiac biomarkers Troponin T (TnT) and N-terminal pro-B-type natriuretic peptide (proBNP) and abdominal aortic calcification score (AAC) are associated with cardiovascular events and mortality in patients with chronic kidney disease (CKD). The effects of cardiac biomarkers and AAC on maximal exercise capacity in CKD are unknown and were studied. Methods 174 CKD 4-5 patients not on maintenance dialysis underwent maximal bicycle ergometry stress testing, lateral lumbar radiograph to study AAC, echocardiography and biochemical assessments. Results The subjects with proportional maximal ergometry workload (WMAX%) less than 50% of the expected values had higher TnT, proBNP, AAC, left ventricular end-diastolic diameter, left ventricular mass index, E/e’ and pulse pressure, and lower global longitudinal strain compared to the better performing patients. TnT (β= -0.09, p=0.02), AAC (β= -1.67, p<0.0001) and diabetes (β= -11.07, p<0.0001) remained significantly associated with WMAX% in the multivariable model. Maximal ergometry workload (in Watts) was similarly associated with TnT and AAC in addition to age, male gender, hemoglobin and diastolic blood pressure in a respective multivariate model. AAC and TnT showed fair predictive power for WMAX% less than 50% of the expected value with AUCs of 0.70 and 0.75, respectivelyConclusions TnT and AAC are independent determinants of maximal ergometry stress test workload in patients with advanced CKD.http://www.ClinicalTrials.gov NCT04223726

scholarly journals Association of maximal stress ergometry performance with troponin T and abdominal aortic calcification score in advanced chronic kidney disease

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Roosa Lankinen ◽  
Markus Hakamäki ◽  
Kaj Metsärinne ◽  
Niina Koivuviita ◽  
Jussi P. Pärkkä ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Troponin T ◽  
Global Longitudinal Strain ◽  
Left Ventricular ◽  
Aortic Calcification ◽  
Cardiac Biomarkers ◽  
Abdominal Aortic Calcification ◽  
Abdominal Aortic ◽  
Calcification Score

Abstract Background Cardiac biomarkers Troponin T (TnT) and N-terminal pro-B-type natriuretic peptide (proBNP) and abdominal aortic calcification score (AAC) are associated with cardiovascular events and mortality in patients with chronic kidney disease (CKD). The effects of cardiac biomarkers and AAC on maximal exercise capacity in CKD are unknown and were studied. Methods One hundred seventy-four CKD 4–5 patients not on maintenance dialysis underwent maximal bicycle ergometry stress testing, lateral lumbar radiograph to study AAC, echocardiography and biochemical assessments. Results The subjects with proportional maximal ergometry workload (WMAX%) less than 50% of the expected values had higher TnT, proBNP, AAC, left ventricular end-diastolic diameter, left ventricular mass index, E/e’ and pulse pressure, and lower global longitudinal strain compared to the better performing patients. TnT (β = − 0.09, p = 0.02), AAC (β = − 1.67, p < 0.0001) and diabetes (β = − 11.7, p < 0.0001) remained significantly associated with WMAX% in the multivariable model. Maximal ergometry workload (in Watts) was similarly associated with TnT and AAC in addition to age, male gender, hemoglobin and diastolic blood pressure in a respective multivariate model. AAC and TnT showed fair predictive power for WMAX% less than 50% of the expected value with AUCs of 0.70 and 0.75, respectively. Conclusions TnT and AAC are independently associated with maximal ergometry stress test workload in patients with advanced CKD. Trial registration http://www.ClinicalTrials.gov NCT04223726.

scholarly journals Chronic Kidney Disease on Health-Related Quality of Life in Patients with Diabetes Mellitus: A National Representative Study

2021 ◽  
Vol 10 (20) ◽  
pp. 4639
Author(s):  
Yun Soo Hong ◽  
Hoon Kim ◽  
Di Zhao ◽  
AJin Cho
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Representative Study ◽  
Stage 4 ◽  
Ckd Stage ◽  
Related Quality ◽  
Health Related ◽  
Nationally Representative ◽  
Anxiety Depression

Importance: With an increasing prevalence of diabetes mellitus (DM) and comorbid chronic kidney disease (CKD), health-related quality of life (HRQoL) in patients with DM and CKD needs to be better understood. Objective: To investigate the association between the severity of CKD on HRQoL in DM patients. Design: A cross-sectional study of a nationally representative population-based survey, the Korea National Health and Nutrition Examination Survey (KNHANES). Setting: Data collected between 2007 and 2018 from the KNHANES. Participants: Adult participants with DM who completed the self-administered European Quality of Life Questionnaire Five Dimension (EQ-5D) questionnaire (n = 7243). Exposures: CKD stages defined by the Kidney Disease Improving Global System (KDIGO) staging system. Main Outcomes and Measures: We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of the presence of having problems in the 5 dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) of EQ-5D by CKD stage after adjusting for socio-demographic parameters and comorbid conditions. In addition, the EQ-5D index, reflecting the overall health status, was compared across CKD stages. Results: Among 7243 participants (mean (standard error) age 58.2 (0.2) 56.9% male), 24.0% (n = 1768) had CKD and 8.6% (n = 775) had stage 3–5 CKD. Pain/discomfort was the most common problem (30.5%) among patients with DM. Participants with more advanced CKD were more likely to experience problems in all dimensions of EQ-5D except the anxiety/depression dimension. In particular, compared to those without CKD, the adjusted ORs (95% CI) for any problem in the usual activities dimension was 1.65 (1.30, 2.10) in CKD stage 3 and 4.23 (2.07, 8.67) in CKD stage 4–5. Moreover, participants with stage 3 (−0.016 (−0.029, −0.003)) and stage 4–5 CKD (−0.088 (−0.129, −0.048)) had significantly lower EQ-5D index than those without CKD. However, compared with no CKD, CKD stage 1–2 was not significantly associated with having any problem in any dimensions. Conclusions and Relevance: In this nationally representative study, patients with DM had a high prevalence of self-reported poor HRQoL and the prevalence increased with more advanced stages of CKD. Therefore, assessment of HRQoL and interventions are necessary at early stages of CKD in DM patients.

scholarly journals Qualidade de vida de clientes em hemodiálise e necessidades de orientação de enfermagem para o autocuidado

2011 ◽  
Vol 15 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Iraci dos Santos ◽  
Renata de Paula Faria Rocha ◽  
Lina Márcia Miguéis Berardinelli
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Rio De Janeiro ◽  
Short Form

Este trabalho relaciona necessidades de orientação de enfermagem com a qualidade de vida de clientes com doença renal crônica, em hemodiálise, considerando conceitos de Autocuidado de Orem. Método descritivo, mediante entrevista com 43 clientes de um Hospital Universitário do Rio de Janeiro, de 2008 a 2009. Os sujeitos de pesquisa têm hipertensão arterial, encontrando-se 83,72% em hemodiálise há menos de um ano. Aplicando o Kidney Disease Quality of Life Short Form, obtiveram-se os menores escores nas dimensões: física; emocional; condição de trabalho; capacidade funcional. Esses resultados foram relacionados aos obtidos com as necessidades de orientação de enfermagem para nutrição, ingestão de líquidos, complicações da hemodiálise, anticoagulação, atividade física, de lazer e associação a grupos, concluindo-se que esses clientes encontram-se no Sistema de Autocuidado totalmente compensatório. Sugere-se o desenvolvimento da orientação de enfermagem para o autocuidado, em consulta de enfermagem, visando promover a qualidade de vida dos clientes.

scholarly journals Adultos e idosos em hemodiálise: avaliação da qualidade de vida relacionada à saúde

2008 ◽  
Vol 21 (spe) ◽  
pp. 152-159 ◽  
Author(s):  
Luciana Kusumoto ◽  
Sueli Marques ◽  
Vanderlei José Haas ◽  
Rosalina Aparecida Paterzani Rodrigues
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Short Form

OBJETIVOS: Caracterizar os adultos e idosos em hemodiálise residentes em Ribeirão Preto-SP. Avaliar e descrever as diferenças na Qualidade de Vida Relacionada à Saúde (QVRS) desses pacientes. MÉTODOS: Estudo seccional e populacional com 194 pacientes em hemodiálise em quatro serviços de diálise do município. Os instrumentos utilizados foram: para caracterização da população, Mini Exame do Estado Mental e Kidney Disease and Quality of Life-Short Form (KDQOL-SF TM). RESULTADOS: Dos pacientes, 132 eram adultos e 62 idosos. Foram encontradas diferenças entre os escores médios dos dois grupos, com significância estatística nas dimensões do KDQOL-SF TM: Funcionamento físico, Função física, emocional, Sobrecarga da doença renal e Estímulo da equipe de diálise. CONCLUSÃO: A insuficiência renal crônica terminal e a hemodiálise se relacionaram com a QVRS dos adultos e idosos. Os resultados podem subsidiar a atuação dos profissionais da saúde para atender as necessidades iminentes, prevenir complicações, enfim almejar uma melhor QVRS.

scholarly journals Trabalho e qualidade de vida relacionada à saúde de pacientes em diálise peritoneal

2012 ◽  
Vol 25 (3) ◽  
pp. 352-357 ◽  
Author(s):  
Marília Pilotto de Oliveira ◽  
Luciana Kusumota ◽  
Sueli Marques ◽  
Rita de Cássia Helú Mendonça Ribeiro ◽  
Rosalina Aparecida Partezani Rodrigues ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Short Form

OBJETIVO: Descrever e comparar a Qualidade de Vida Relacionada à Saúde (QVRS) de pacientes em Diálise Peritoneal (DP) que tinham ou não trabalho remunerado. MÉTODOS: Estudo seccional e populacional com 82 pacientes dos dois serviços de DP de Ribeirão Preto, (SP). A coleta de dados foi realizada por entrevistas entre dezembro/2009 e março/2010. Os questionário para caracterização dos pacientes, o Miniexame do Estado Mental e o Kidney Disease and Quality of Life-Short Form foram usados. Foram feitas as análises estatística exploratória uni e bivariada e a confirmatória bivariada entre variáveis independentes e as dimensões de QVRS. RESULTADOS: os pacientes com trabalho remunerado apresentavam maiores escores médios refletindo melhor QVRS para a maioria das dimensões do instrumento utilizado. CONCLUSÃO: o trabalho é uma faceta importante da vida desses pacientes e merece a atenção dos profissionais da saúde na busca de estratégias que favoreçam e incentivem sua manutenção e reinserção no mercado de trabalho.

scholarly journals HUBUNGAN KOMPLIKASI INTRA HEMODIALISIS DENGAN KUALITAS HIDUP PADA PASIEN CHRONIC KIDNEY DISEASE (CKD) STAGE V YANG MENJALANI HEMODIALISIS DI RUANG HEMODIALISA BRSU TABANAN TAHUN 2017

2018 ◽  
Vol 2 (1) ◽  
pp. 9
Author(s):  
Kadek G Pebriantari ◽  
IGA Puja Astuti Dewi
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Significant Relationship ◽  
Chi Square ◽  
Cross Sectional ◽  
Probability Sampling ◽  
Ckd Stage ◽  
Non Parametric

ABSTRAKLatar Belakang. Hemodialisis aman dan bermanfaat untuk pasien, namun bukan berarti tanpa efek samping. Berbagai komplikasi dapat terjadi pada saat pasien menjalani hemodialisis. Komplikasi ini dapat mengakibatkan timbulnya masalah baru yang lebih kompleks, yaitu dapat mempengaruhi kualitas hidup bahkan menimbulkan kematianTujuan. Untuk mengetahui hubungan komplikasi intra hemodialisis dengan kualitas hidup  pada pasien Chronic Kidney Disease (CKD) Stage V yang menjalani hemodialisis.Metode. Jenis penelitian adalah analitik korelasional dengan pendekatan cross-sectional. Sampel pada penelitian ini berjumlah 166 responden diambil dengan teknik non probability sampling yaitu total sampling. Pengumpulan data menggunakan kuesioner dan lembar observasi,dianalisa dengan uji non parametric (Chi Square).Hasil. Rata – rata jumlah komplikasi intra hemodialisis adalah kurang dari dua komplikasi (sedikit komplikasi). Hipertensi intra hemodialisis adalah komplikasi terbanyak yang ditemukan (52,3%). Kejang dan penurunan kesadaran merupakan komplikasi yang tidak pernah dialami oleh responden selama penelitian (0%).Kualitas hidup pasien CKD stage V yang menjalani HD di BRSU Tabanan masuk dalam kategori kualitas baik. Hasil uji statistik diperoleh nilai p < 0.001 bahwa ada hubungan yang signifikan antara komplikasi intra hemodialisis dengan  kualitas hidup pada pasien yang menjalani HD. Dari hasil analisis diperoleh pula nilai OR = 0,005, artinya responden yang memiliki banyak komplikasi mempunyai peluang 0,005 kali memiliki kualitas hidup buruk dibanding responden yang memiliki sedikit komplikasi.Kesimpulan. Ada hubungan yang signifikan antara komplikasi intra hemodialisis dengan  kualitas hidup pada pasien yang menjalani hemodialisis.KataKunci: Komplikasi Intra Hemodialisis, Kualitas Hidup, Hemodialisis ABSTRACTBackground: Hemodialysis is safe and beneficial to the patient. However, there are various complications may occur when the patients undergo hemodialysis. These complications can lead to the emergence of new problems which are more complex and affect to the quality of life and even cause death.Aim: To determine the relationship of intra hemodialysis complications with quality of life in patients with Chronic Stage Kidney Disease (CKD) Stage V who undergo hemodialysis.Method:This study employed correlational analytic design with cross-sectional approach. To conduct this study, there were 166 respondents recruited as the sample by using probability sampling with total sampling technique. The data were collected by using questionnaire and observation sheet. Further, the data were analyzed by non-parametric test (Chi Square).Finding: The findings indicated that the average number of intra hemodialysis complications is less than two complications (few complications). There were found that 52.3% patients who had complication of hypertension intra hemodialysis. On the other hand, there was 0%of the respondents experienced seizures and decreased awareness complications during the study. The quality of life of CKD stage V patients underwenthemodialysis at BRSU Tabanan is categorized as good quality. The statistical test obtained p <0.001, it meant that there was a significant relationship between intra hemodialysis complications with quality of life in patients underwenthemodialysis. It also found that the analysis results of OR = 0.005, it meant that respondents who had many complications have a chance of 0.005 times experienced poor quality of life rather than the patients who had few complications.Conclusion: There is a significant relationship between intra hemodialysis complications and quality of life in patients undergo hemodialysis. Keywords: Complications of Intra Hemodialysis, Quality of Life, Hemodialysis

scholarly journals Ativação de pacientes em hemodiálise: fatores associados e qualidade de vida relacionada à saúde

2021 ◽  
Author(s):  
◽  
Denise Rocha Raimundo Leone
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Short Form ◽  
Patient Activation ◽  
Minas Gerais ◽  
Patient Activation Measure

Introdução: o tratamento hemodialítico impõe modificações no cotidiano do indivíduo e demanda autogerenciamento eficaz da saúde para que se alcancem as metas terapêuticas e consequentemente uma melhor qualidade de vida relacionada à saúde. Há evidências de que pessoas com altos níveis de ativação apresentam comportamentos mais saudáveis e melhores desfechos clínicos quando comparadas a pessoas com baixa ativação. Dessa forma, mensurar a ativação dos pacientes em hemodiálise possibilita a identificação do grau de autogerenciamento destes e viabiliza intervenções de saúde direcionadas ao indivíduo, considerando suas crenças, habilidades e motivações. Objetivo: avaliar o nível de ativação de pacientes em hemodiálise e seus fatores associados. Metodologia: estudo com abordagem quantitativa e corte transversal, realizado com 162 pessoas em tratamento hemodialítico de uma unidade de terapia renal substitutiva, sediada no município de Juiz de Fora, Minas Gerais. Os participantes responderam a dois questionários, um para avaliação sociodemográfica e clínica e outro para classificação econômica, e também a duas escalas, uma para mensurar o nível de ativação (Patient Activation Measure-13) e outra para avaliação da qualidade de vida (Kidney Disease Quality of life short form). Foram coletados dados secundários, referentes aos resultados de exames laboratoriais e valores de ultrafiltração, para avaliação dos resultados em saúde. Foi realizada a análise descritiva dos dados para caracterização da população, regressão de Poisson com variância robusta para verificar associação entre o escore de ativação e os dados sociodemográficos, socioeconômicos e clínicos e regressão Logística com a finalidade de estabelecer o relacionamento entre os níveis de ativação com a qualidade de vida relacionada à saúde. Utilizou-se o software SPSS versão 23.0 e o STATA. Resultados: foram construídos dois artigos intitulados “Fatores associados à ativação de pacientes em hemodiálise “e “Nível de ativação e qualidade de vida relacionada à saúde de pessoas em hemodiálise”. Ressalta-se que dos participantes, 63% eram homens, a idade média foi de 59,23+ 15 anos e 74,1% realizavam tratamento há menos de cinco anos. O escore médio da ativação do paciente foi de 60,85 +15,57, sendo a mediana de 53,2 (intervalo de confiança: 58,4 – 63,3). Associou-se à maior prevalência de alta ativação possuir nível superior de ensino e não necessitar de cuidador e à menor prevalência de alta ativação ter o domicílio classificado como B2 ou D-E e não ter realizado previamente outra terapia renal substitutiva. Em relação a ativação e qualidade de vida, o nível de ativação foi associado aos domínios sintomas, funcionamento físico, saúde geral, bem-estar emocional, energia/fadiga e o componente mental da qualidade de vida relacionada à saúde. Conclusão: a maior parte de pessoas em hemodiálise não possuem habilidades, conhecimentos e motivações o suficiente para serem responsáveis pelo autogerenciamento de sua saúde, o que reforça a relevância da atuação profissional em realizar intervenções de saúde que visem melhorar os níveis de ativação dessa população.

Ποιότητα ζωής ασθενών με χρόνια νεφρική ανεπάρκεια που υποβλήθηκαν σε επιτυχή μεταμόσχευση νεφρού

2019 ◽  
Author(s):  
Αικατερίνη Μπαλάσκα
Keyword(s):  
Quality Of Life ◽  
Kidney Disease ◽  
Short Form

Η αξιολόγηση της ποιότητας ζωής των ασθενών που βρίσκονταν σε αιμοκάθαρση και υποβλήθηκαν σε επιτυχή μεταμόσχευση νεφρού διατηρώντας το μόσχευμα πέντε χρόνια μετά την μεταμόσχευση, καθώς και η διερεύνηση των παραγόντων που την επηρεάζουν.Υλικό- Μέθοδος: Η έρευνα έγινε σε μια ομάδα ασθενών Ν 120 ξεκινώντας από το 2009. Πραγματοποιήθηκε μία προ-μέτρηση (πριν την μεταμόσχευση) και δύο μετά-μετρήσεις (24 και 60 μήνες μετά την μεταμόσχευση)]. Η συλλογή των δεδομένων έγινε με συνέντευξη και χρησιμοποιήθηκε το ερωτηματολόγιο KDQOL-SF (Kidney Disease Quality of Life Short Form). Αποτελέσματα: Η μέση ηλικία των νεφροπαθών ήταν 51,2 έτη, το 71% ήταν άντρες και το 29% ήταν γυναίκες. Το 54,2% των νεφροπαθών διέμεναν μόνιμα στην Αθήνα, ενώ το 45,8% στην επαρχία. Το 79,4% ήταν έγγαμοι και το 20,6% ήταν άγαμοι/διαζευγμένοι/χήροι, ενώ το 76,6% είχαν παιδιά και το 23,4% δεν είχαν παιδιά. Το 29% ήταν απόφοιτοι γυμνασίου, το 29% ήταν απόφοιτοι δημοτικού, το 24,3% ήταν απόφοιτοι λυκείου, το 13,1% ήταν απόφοιτοι ΑΕΙ/ΤΕΙ και το 4,7% ήταν αγράμματοι. Το 59,8% των νεφροπαθών δεν ήταν συνταξιούχοι, ενώ το 40,2% ήταν συνταξιούχοι.Ο μέσος αριθμός ετών αιμοκάθαρσης ήταν 4,8. Το 91,6% των νεφροπαθών έλαβαν μόσχευμα από πτωματικό δότη, ενώ το 8,4% έλαβαν μόσχευμα από ζωντανό δότη. Το 92.5 % των νεφροπαθών επεβίωσαν έπειτα από τα πέντε χρόνια διεξαγωγής της μελέτης και 9 ασθενείς έχουν αποβιώσει ποσοστό 7,5 % Η συνολική ποιότητα ζωής (SF) μετά την επιτυχή μεταμόσχευση νεφρού παρουσίασε θεαματική βελτίωση. Ιδιαίτερα οι πιο θεαματικές μεταβολές παρατηρήθηκαν στην φυσική κατάσταση καθώς και στο συναισθηματικό επίπεδο. Στο ειδικό για τη νόσο ερωτηματολόγιο KDQOL στατιστικά σημαντική βρέθηκε να είναι η βελτίωση στην ποιότητα της ζωής ένα χρόνο μετά τη μεταμόσχευση και ιδιαίτερα θεαματικές μεταβολές παρατηρήθηκαν στην επιβάρυνση από την ίδια τη νόσο, στην γενετήσια λειτουργικότητα, στα συμπτώματα και στον ύπνο.Οι ασθενείς που έλαβαν μόσχευμα από ζωντανό δότη είχαν ελαφρά υψηλότερο σκορ στην ποιότητα της ζωής τους σε σχέση με αυτούς που είχαν λάβει πτωματικό μόσχευμα. Επίσης καλύτερη ποιότητα ζωής φάνηκαν να έχουν οι ασθενείς που είχαν παιδιά σε σχέση με αυτούς που δεν είχαν.Τέλος όσο περισσότερο χρόνο βρίσκονταν οι ασθενείς στην αιμοκάθαρση τόσο καλύτερη και η ποιότητα ζωής τους μετά την μεταμόσχευση.Συμπέρασμα: Το τελικό στάδιο της νεφρικής ανεπάρκειας είναι μια χρόνια κατάσταση η οποία μειώνει σημαντικά την ποιότητα ζωής των θυμάτων της. Η μεταμόσχευση νεφρού είναι η θεραπεία εκλογής για πολλούς απ΄ αυτούς τους αρρώστους. Όπως φάνηκε μέσα από την παρούσα μελέτη, η επιτυχημένη μεταμόσχευση νεφρού προάγει σημαντικά την ποιότητα ζωής των ασθενών σε σχέση με την αιμοκάθαρση.

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