Birthweight Differences in Adolescent Monozygotic Twins Influence Androgens, Psychological Morbidity, and Health-Related Quality of Life

2021 ◽  
pp. 1-9
Author(s):  
Lioba Schmitz ◽  
Sandra Schulte ◽  
Birgit Stoffel-Wagner ◽  
Peter Bartmann ◽  
Michaela Plamper ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Well Being ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related ◽  
Parental Evaluation ◽  
Discordant Twins ◽  
Lower Hrqol

<b><i>Background:</i></b> Adverse prenatal conditions can exert a long-lasting impact in later life. <b><i>Patients and Methods:</i></b> Thirty-eight post-pubertal monozygotic twin pairs (16 female pairs) with divergent birthweight (bw) due to twin-to-twin transfusion syndrome were examined at a median of 15.1 years. Auxological and endocrine parameters were measured. To evaluate effects of intra-twin bw and hormone differences on mental health, adolescents and their parents completed the Strengths and Difficulties Questionnaire (SDQ), identifying psychological problems. Twins answered the questionnaire on health-related quality of life (HrQoL, KIDSCREEN-52). <b><i>Results:</i></b> Parents attributed a higher number of psychological challenges to the formerly smaller twins, for example, total difficulties (8.8 vs. 6.5, <i>p</i> = 0.009). Differences in bw were associated with differences in parental evaluation of problems, for example, peer relationship problems (<i>r</i> = −0.57 and <i>p</i> = 0.0001). In contrast, bw differences did not affect subjects’ self-assessment of psychological factors but on physical well-being (<i>r</i> = 0.42, <i>p</i> = 0.017). The formerly smaller discordant twins showed significantly lower HrQoL regarding psychological well-being (24.9 vs. 26.6, <i>T</i><sub>1,15</sub> = −2.2, and <i>p</i> = 0.043) and moods and emotions (29.8 vs. 32.0, <i>T</i><sub>1,15</sub> = −2.3, <i>p</i> = 0.039). Higher concentrations of androstenedione were linked to greater psychological well-being (<i>r</i> = 0.39 and <i>p</i> = 0.036) in all twin pairs. <b><i>Conclusion:</i></b> Our results show that the prenatal environment leading to bw differences exerts a long-lasting impact on diverging parental evaluation of mental health. Formerly smaller discordant twins showed significantly lower HrQoL regarding psychological well-being and moods and emotions. Higher androstenedione concentrations were linked to greater psychological well-being.

scholarly journals The relationship of self-reported and device-based measures of physical activity and health-related quality of life in adolescents

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Kathrin Wunsch ◽  
Claudio R. Nigg ◽  
Susanne Weyland ◽  
Darko Jekauc ◽  
Claudia Niessner ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
School Environment ◽  
Protective Factor ◽  
Well Being ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related

Abstract Background Physical activity (PA) has beneficial effects on health and health-related quality of life (HRQoL), which is a protective factor of illness and mortality. The purpose of this examination was to investigate if self-reported and device-based measures of PA were related to HRQoL in adolescents. Methods Participants (N = 1565; 54.3% female; Mage = 14.37 years, SDage = 1.99) were recruited from 167 sample points across Germany. Adolescents self-reported their PA, supplemented by a 1-week examination of device-based PA using accelerometry. Additionally, they completed the multidimensional KIDSCREEN-27 to assess HRQoL. Results Results showed that self-reported PA was correlated with overall HRQoL, Physical Well-Being, Psychological Well-Being, Social Support & Peers, and School Environment, whereas device-based PA was only correlated with Physical as well as Psychological Well-Being. Further, self-reported PA significantly predicted all facets of HRQoL except for Autonomy and Parent Relations, whereas device-based PA solely heightened the amount of explained variance in the Physical Well-Being subscale. Conclusions Findings demonstrate the importance of self-reported PA as it is related to almost all facets of HRQoL. Both measures of PA are not congruent in their relationship with HRQoL and thus implications have to be carefully considered. Future studies should investigate the direct effect of PA on HRQoL and health in a longitudinal approach to account for the causality of effects.

scholarly journals Inferior health-related quality of life and psychological well-being in immigrant cancer survivors: A population-based study

2013 ◽  
Vol 49 (8) ◽  
pp. 1948-1956 ◽  
Author(s):  
Phyllis N. Butow ◽  
Lynley Aldridge ◽  
Melanie L. Bell ◽  
Ming Sze ◽  
Maurice Eisenbruch ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Survivors ◽  
Well Being ◽  
Population Based ◽  
Health Related Quality ◽  
Population Based Study ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related

scholarly journals Sleep and Its Importance for Health-Related Quality of Life in 3–10-year-old Children

2020 ◽  
Author(s):  
Charlotte Angelhoff ◽  
Anna Lena Sundell
Keyword(s):  
Quality Of Life ◽  
School Environment ◽  
Sleep Problems ◽  
Well Being ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related ◽  
Children’S Sleep

Abstract Purpose Considering the reports of increasing sleep problems in children, affecting health and well-being in young children and their families, we found it important to gain more knowledge about sleep and its correlation to health-related quality of life (HRQoL) in young, healthy children. The aim with this study was to describe sleep quality, sleep duration, and HRQoL in healthy 3–10-year-old children and to test associations between children’s sleep and HRQoL. Methods Parents of 160 children (average age: 6.9 years, SD ±2.2) participated in the study. Sleep onset problems (SOP), sleep maintenance problems (SMP), and sleep duration were measured by the Pediatric Insomnia Severity Index (PISI). KIDSCREEN-27 was used to measure HRQoL in five dimensions: physical well-being, psychological well-being, autonomy and parent relation, social support and peers, and school environment. Results The average score was 2.2 for SOP (SD +/-2.2) and 1.3 for SMP (SD +/-1.6). Almost all children (98%) slept between 8 and 13 hours per night. Younger children had statistically significantly more sleep problems than older children. Correlations were found between SOP and poor psychological well-being ( p < 0.05, ρ = - 0.16), and between SMP and poor psychological well-being ( p < 0.05, ρ = - 0.21), poor school environment ( p < 0.01, ρ = - 0.29), and poor social support and peers ( p < 0.05, ρ = - 0.19). Conclusion Children’s sleep associates with psychosocial well-being, school functioning and relations to peers, and need to be acknowledged in child health care settings and schools.

scholarly journals Health-related quality of life and psychological well-being in elderly patients with haemophilia

Haemophilia ◽  
2011 ◽  
Vol 18 (3) ◽  
pp. 345-352 ◽  
Author(s):  
S. VON MACKENSEN ◽  
A. GRINGERI ◽  
S. M. SIBONI ◽  
P. M. MANNUCCI ◽  
Keyword(s):  
Quality Of Life ◽  
Elderly Patients ◽  
Well Being ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related

Health-related quality of life and psychological well-being in patients with benign prostatic hyperplasia

2014 ◽  
Vol 24 (3-4) ◽  
pp. 511-522 ◽  
Author(s):  
Julian Dong Oh Pinto ◽  
Hong-Gu He ◽  
Sally Wai Chi Chan ◽  
Poh Choo Toh ◽  
Kesavan Esuvaranathan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Benign Prostatic Hyperplasia ◽  
Well Being ◽  
Prostatic Hyperplasia ◽  
Health Related Quality ◽  
Psychological Well Being ◽  
Related Quality ◽  
Health Related

scholarly journals Children of Parents with a Mental Illness: Predictors of Health-Related Quality of Life and Determinants of Child–Parent Agreement

2021 ◽  
Vol 18 (2) ◽  
pp. 379
Author(s):  
Alina Radicke ◽  
Claus Barkmann ◽  
Bonnie Adema ◽  
Anne Daubmann ◽  
Karl Wegscheider ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Illness ◽  
Protective Factors ◽  
Well Being ◽  
Parental Psychopathology ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Lower Hrqol

(1) Background: Health-related quality of life (HRQoL) is frequently reduced in children of parents with a mental illness (COPMI). Child self- and parent proxy-ratings vary with raters’ characteristics and facets of HRQoL. This study aimed at analyzing risk and protective factors associated with HRQoL in COPMI, and at examining the magnitude, direction, and predictors of child–parent agreement. (2) Methods: Analyses were based on baseline data of the German CHIMPS (children of parents with a mental illness) project with n = 134 parents diagnosed with mental illness and n = 198 children and adolescents aged 8 to 18 years. (3) Results: Both children and parents reported significantly lower HRQoL than the reference population, particularly for the child’s physical and psychological well-being. Parents’ proxy-report indicated a lower HRQoL than the children’s self-report. Child and parental psychopathology, social support, and the child’s age significantly predicted HRQoL. Interrater agreement was satisfactory and better for observable aspects like physical well-being and school environment. The child’s gender-identity and mental health significantly predicted child–parent agreement. (4) Conclusions: Parental psychopathology significantly reduces children’s HRQoL. Interventions should promote resilience in children by targeting risk and protective factors. Child–parent agreement emphasizes the need to obtain both self- and proxy-reports, whenever possible.

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