scholarly journals Refractory Hyperlactatemia and Hypoglycemia in an Adult with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Warburg Effect

2021 ◽  
pp. 1159-1167
Author(s):  
Zainab Al Maqrashi ◽  
Mary Sedarous ◽  
Avinash Pandey ◽  
Catherine Ross ◽  
Ahraaz Wyne
Keyword(s):  
Lactic Acidosis ◽  
Warburg Effect ◽  
Hodgkin’S Lymphoma ◽  
Abdominal Mass ◽  
Hodgkin's Lymphoma ◽  
Type B ◽  
Elderly Male ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
The Warburg Effect

Lactate is a byproduct of anaerobic glycolysis, and hyperlactatemia is commonly seen in critically ill patients. We report a case of an elderly male presenting with undifferentiated constitutional symptoms, anemia, thrombocytopenia, severe lactic acidosis, refractory hypoglycemia, and a newly detected abdominal mass. A dedicated workup ruled out infectious etiologies and revealed metastatic non-Hodgkin’s lymphoma. This study explores etiologies of type B lactic acidosis in oncology patients, with a focus on Warburg’s effect, and its potential for prognostication.

scholarly journals Lactic Acidosis, Multiorgan Failure and Pneumatosis: A Rare Presentation of Lymphoma

2013 ◽  
Vol 2 (2) ◽  
pp. 94-96
Author(s):  
Phillip A Letourneau ◽  
Shinil K Shah ◽  
Amanda Tchakarov ◽  
Allen H Tanner ◽  
Robert A Hetz ◽  
...  
Keyword(s):  
Lactic Acidosis ◽  
Hodgkin’S Lymphoma ◽  
Mesenteric Ischemia ◽  
Multiorgan Failure ◽  
Pneumocystis Pneumonia ◽  
Hodgkin's Lymphoma ◽  
Mesenteric Lymph Nodes ◽  
Rare Presentation ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

ABSTRACT A 43-year-old man with a past medical history of HIV/AIDS presented with a cough, fever and night sweats. He was febrile, with normal heart rate and blood pressure. Initial laboratory testing included a mild leukocytosis. Chest X-ray demonstrated a right perihilar opacity and bilateral pleural effusions. He was admitted for treatment of pneumocystis pneumonia vs tuberculosis. He developed respiratory failure and was transferred to the ICU. He subsequently developed abdominal pain and severe lactic acidosis. CT scan demonstrated pneumatosis. Considering the clinical concern for mesenteric ischemia he was taken to the operating room, where it was noted that he had hepatomegaly and viable bowel. The mesentery demonstrated diffuse lymphadenopathy. Mesenteric lymph nodes were biopsied. He failed to improve clinically and his leukocytosis continued to increase to as high as 102,000, with a blood smear revealing atypical appearing lymphocytes. The patient continued to decline and ultimately died. Autopsy results demonstrated diffuse non-Hodgkin's lymphoma. Only 30 cases of non-Hodgkin's lymphoma have been reported in the literature as causing liver failure. This is the only case that included pneumatosis and lactic acidosis that mimicked mesenteric ischemia. How to cite this article Letourneau PA, Shah SK, Tchakarov A, Tanner AH, Hetz RA, Jani PP, Walker PA, Martinez EJ, Khan SA. Lactic Acidosis, Multiorgan Failure and Pneumatosis: A Rare Presentation of Lymphoma. Panam J Trauma Critical Care Emerg Surg 2013;2(2):94-96.

Hypoglycaemia and Lactic Acidosis in a MALT Non Hodgkin's Lymphoma

2002 ◽  
Vol 43 (6) ◽  
pp. 1341-1342 ◽  
Author(s):  
Gabriele Di Comite ◽  
Lorenzo Dagna ◽  
Piero M. Piatti ◽  
Lucilla D. Monti ◽  
Francesca Tantardini ◽  
...  
Keyword(s):  
Lactic Acidosis ◽  
Hodgkin’S Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

scholarly journals Non-Hodgkin’s Lymphoma in Colon

1970 ◽  
Vol 8 (2) ◽  
pp. 74-75
Author(s):  
Monzorul Hasan Chowdhury ◽  
Fasle Rabbi Chowdhury ◽  
Fazle Rabbi Mohammed ◽  
Md Ziaus Shams ◽  
Md Billal Alam
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Epigastric Pain ◽  
Abdominal Mass ◽  
Interesting Case ◽  
Hodgkin's Lymphoma ◽  
Chronic Diarrhoea ◽  
Intermediate Grade ◽  
Abdominal Lymph Node ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma

The incidence of Non-Hodgkin's lymphoma has steadily risen and while other cancers have increased 25%, NHL has increased >80%. In the majority of NHL patients, the disease arises in lymph nodes, but primary extranodal disease accounts for 30% of new lymphoma patients and often present as localized disease. We report a rare and interesting case of intermediate grade diffuse Non-Hodgkin's lymphoma in colon. A 30year old man presented to our department with the complaints of mild epigastric pain, occasional loose stools and, abdominal swelling for 3 months along with significant weight loss for the last 2 months. On examination, he appeared cachectic with only 33 kg, an intra-abdominal mass was palpable in the epigastrium rt side from the midline measuring 3cmx5cm, hard in consistency but does not move with respiration which was consisted with abdominal lymph node. USG guided FNAC of right upper abdominal mass revealed: Non-Hodgkin's lymphoma. Biopsy report of tissue from colon revealed diffuse non- Hodgkin's lymphoma, intermediate grade. To our knowledge, very few cases are reported so far with similar presentations and finally diagnosed with non-hodgkin's lymphoma of colon. Thus, in our clinical practice, if a middle aged person present with wt. loss, chronic diarrhoea, and abdominal swelling, we should also suspect this might be a case of Non-Hodgkin's lymphoma of colon as an extranodal presentation. DOI = 10.3329/jom.v8i2.1413 J MEDICINE 2007; 8 : 74-75

Primary Non-Hodgkin's Lymphoma of the Frontal Sinus: Case Report and Review of the Literature

2005 ◽  
Vol 84 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Maura C. Neves ◽  
Marcus M. Lessa ◽  
Richard L. Voegels ◽  
Ossamu Butugan
Keyword(s):  
Frontal Sinus ◽  
Hodgkin’S Lymphoma ◽  
Sinonasal Tract ◽  
Hodgkin's Lymphoma ◽  
Type B ◽  
Upper Eyelid ◽  
Primary Tumor Site ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Primary Type

Non-Hodgkin's lymphoma of the sinonasal tract is an uncommon lesion, representing 1.5 to 15% of all lymphomas. Most cases of primary non-Hodgkin's lymphoma of the sinonasal tract occur in the maxillary sinus, ethmoid sinus, and nasal cavity; its occurrence in the frontal sinus is extremely rare. We report a case of primary type B non-Hodgkin's lymphoma of the frontal sinus in a 43-year-old man. The patient complained of frontal headaches that had not improved with analgesic drugs, and he presented with a frontal bulge that involved the left upper eyelid; the bulge had progressively enlarged over a 3-month period. A biopsy of the mass identified the type B non-Hodgkin's lymphoma. Immunohistochemical study not only confirmed the histologic type of the tumor, it also provided some important information about the primary tumor site. Advances in immunohistochemistry have shown that type B non-Hodgkin’s lymphoma is more common in North American and European patients, whereas subtype T is more common in Asians and in some Latin Americans. The treatment of this condition is still controversial, but the combination of radiotherapy and chemotherapy has yielded the best results in all stages of the disease.

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