Multiple Tumor-Associated Intracranial Aneurysms Adjacent to a Suprasellar Germ Cell Tumor: Case Report and Review of Literature

2021 ◽  
pp. 1-10
Author(s):  
John K. Yue ◽  
Diana Chang ◽  
Taemin Oh ◽  
Ethan A. Winkler ◽  
Alex Y. Lu ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Intracranial Aneurysms ◽  
Multidisciplinary Treatment ◽  
Clinical History ◽  
Cell Tumor ◽  
Paracrine Signaling ◽  
Current Case ◽  
Case Presentation ◽  
Multiple Tumor

<b><i>Introduction:</i></b> Tumor-associated intracranial aneurysms are rare and not well understood. <b><i>Case Presentation:</i></b> We describe a 4-year-old female with multiple intracranial aneurysms intimately associated with a suprasellar germ cell tumor (GCT). We provide the clinical history, medical, and surgical treatment course, as well as a comprehensive and concise synthesis of the literature on tumor-associated aneurysms. <b><i>Discussion:</i></b> We discuss mechanisms for aneurysm formation with relevance to the current case, including cellular and paracrine signaling pertinent to suprasellar GCTs and possible molecular pathways involved. We review the complex multidisciplinary treatment required for complex tumor and cerebrovascular interactions.

Spontaneous Complete Regression of Testicular Germ Cell Tumor: A Case Report

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S60-S60
Author(s):  
S Shawn Liu ◽  
Sara Avalos Hernandez ◽  
Valeria Dal Zotto ◽  
Guillermo Herrera
Keyword(s):  
Lymph Node ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Spontaneous Regression ◽  
Cell Tumor ◽  
Complete Regression ◽  
Retroperitoneal Lymph Node ◽  
Testicular Germ Cell ◽  
Current Case ◽  
Histological Features

Abstract Testicular germ cell tumors (TGCTs) may spontaneously regress, making it a diagnostic challenge. We present here a case of 39-year-old African American male with constant abdominal pain radiating into the back. Computed tomography identified bulky retroperitoneal lymphadenopathy. There was no history of testicular trauma. Ultrasonography of right testicle revealed multiple microcalcifications, and a laboratory test indicated elevated beta-hCG and LDH. Patient underwent right orchiectomy, which revealed a grossly well-demarcated white oval lesion (3.1 cm). Histologic examination identified a fibrotic lesion in a background of atrophic parenchyma consistent with scar tissue. The specimen was completely submitted for microscopic evaluation, but neoplasia was not identified. A placental alkaline phosphatase (PLAP) immunohistochemical stain failed to reveal residual germ cell neoplasm in situ. Biopsy of retroperitoneal lymph node identified malignant neoplastic cells expressing PLAP, CD117, CD30, and cytokeratin AE1/AE3. The morphology and immunophenotype were consistent with metastatic germ cell tumor. Spontaneous regression of TGCT is defined as partial or complete tumor disappearance without any treatment. The clinical presentation could be nonspecific. Histologically, tumor regression is indicated by formation of fibrous scar, testicular atrophy, microcalcification, lymphoplasmacytic infiltration, and hemosiderin-phagocytosed macrophages, all of which were present in the current case. However, similar histological features could be identified in testicular ischemia or infraction. Therefore, the diagnosis of complete regression of TGCT is challenging and frequently relies on the present of extragonadal germ cell tumor. In the current case, we reported a spontaneous complete regression of TGCT, supported by a spectrum of histological features and metastasis to retroperitoneal lymph node. Spontaneous regression of TGCT is rare, with less than 150 cases reported in the literature. Since there is a lack of definitive histologic criteria to diagnose complete spontaneous regression of TGCT, when scarring is seen in the testis, additional clinical and imaging evaluation should be followed.

NAD(P)H: Quinone oxidoreductase (NQO1) and catalase expression in nonseminomatous germ cell tumors.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 413-413
Author(s):  
Neda Hashemi-Sadraei ◽  
Nabil Adra ◽  
Kenneth A. Kessler ◽  
Muhammad T. Idrees ◽  
Lawrence Einhorn ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Tumor Resection ◽  
Germ Cell Tumors ◽  
Predictive Marker ◽  
Cell Tumor ◽  
Cancer Center ◽  
Quinone Oxidoreductase ◽  
Lung Cancers ◽  
Multiple Tumor

413 Background: NAD(P)H:quinone oxidoreductase 1 (NQO1) is an enzyme which detoxifies quinones and reduces oxidative stress. NQO1 is expressed in multiple tumor types at levels up to 200-fold above normal tissue, including in breast, pancreatic, and non-small cell lung cancers. NQO1 bioactivatable drugs have the potential to deliver tumor-selective DNA damage and cell death by exploiting the elevation of NQO1. Alterations in catalase expression can cause marked cytoprotection. The ratio of NQO1:catalase activities is presumed to be a predictive marker for therapeutic activity of NQO1 bioactivatable drugs. There is no data available on NQO1 and catalase expression in germ cell tumors. Methods: Patients with germ cell tumor who underwent orchiectomy/tumor resection between January 2016 and December 2018 were identified from the Indiana University Melvin and Bren Simon Cancer Center database. Patients with non-seminomatous germ cell tumor of testis or primary mediastinal non-seminomatous germ cell tumor were selected. Immunohistochemistry staining for NQO1 and catalase was performed on tumor tissue. Results: NQO1 and catalase expression were assessed in 16 patients. Fifteen of 16 tumors stained positive for NQO1, 13 of which were moderately to strongly positive. Conversely, the majority of tumors were catalase deficient or only mildly positive for catalase. The details of the Immunostaining is summarized in the table below. Conclusions: Non-seminomatous germ cell tumors appear to have overexpression of NQO1 and deficiency of catalase. NQO1 bioactivatable agents could be beneficial in treating patients with refractory non-seminomatous germ cell tumors.[Table: see text]

scholarly journals A 28-Year-Old Man With Mediastinal Seminoma Treated With BEP

2021 ◽  
Vol 57 (4) ◽  
pp. 351
Author(s):  
Agustinus Rizki ◽  
Laksmi Wulandari
Keyword(s):  
Partial Response ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Mediastinal Mass ◽  
Cell Tumor ◽  
Shortness Of Breath ◽  
Case Presentation ◽  
Mediastinal Seminoma ◽  
The Right ◽  
Bep Chemotherapy

Highlight:A 28-year-old male suffered chylothorax and mediastinal seminoma.The patient received bleomycin, etoposide and cisplatin chemotherapy for the management of mediastinal seminomas but he died beforeundergoing 5th cycle chemotherapy. Abstract:Seminoma is a type of germ cell tumor. In this case presentation, a rare primary germ cell tumor was reported in the form of mediastinal seminoma. A 28-year-old man with symptoms of shortness of breath, chest pain, swelling in the right upper extremity, enlarged lymph nodes in the colli region. Thoracic physical examination revealed signs of pleural fluid in the right hemithorax. After obtaining the results of radiological and pathological investigations, a mediastinal mass was obtained, then BEP chemotherapy was given. After 3 cycles of chemotherapy, a partial response was obtained. Patients with mediastinal seminoma treated with BEP base chemotherapy gave a partial response.

scholarly journals Leptomeningeal Metastases in a Patient with an Extragonadal Germ Cell Tumor

2008 ◽  
Vol 2 ◽  
pp. CMO.S687
Author(s):  
Yoshiaki Kinebuchi ◽  
Masakuni Ishikawa ◽  
Osamu Ishizuka ◽  
Osamu Nishizawa ◽  
Kazuhiro Hongo
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Multidisciplinary Treatment ◽  
Germ Cell Tumors ◽  
Whole Brain Radiotherapy ◽  
Salvage Chemotherapy ◽  
Leptomeningeal Metastases ◽  
Cell Tumor ◽  
Extragonadal Germ Cell Tumor ◽  
Brain Radiotherapy

We present a case of leptomeningeal metastases in a 30-year-old man with an extragonadal germ cell tumor. The patient was referred to our hospital for treatment of an occipital brain metastasis. This lesion was resected, followed by whole brain radiotherapy and further chemotherapy, and a temporary complete remission was achieved. However, leptomeningeal recurrence developed, and despite salvage chemotherapy, the patient died of disease. Although multidisciplinary treatment is given to treat brain metastases of germ cell tumors, the patients’ prognosis has been unsatisfactory. The identification of a standard/effective treatment is required.

Multidisciplinary treatment of metastatic germ cell tumor clinical summary and discussion

1987 ◽  
Vol 15 (5) ◽  
pp. 257-261 ◽  
Author(s):  
Giulio J. D'Angio ◽  
Audrey E. Evans ◽  
Michael Willoughby
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumor ◽  
Multidisciplinary Treatment ◽  
Cell Tumor

Cisplatin and Etoposide in Childhood Germ Cell Tumor: Brazilian Pediatric Oncology Society Protocol GCT-91

2009 ◽  
Vol 27 (8) ◽  
pp. 1297-1303 ◽  
Author(s):  
Luiz Fernando Lopes ◽  
Carla Renata Pacheco Macedo ◽  
Elitânia Marinho Pontes ◽  
Simone dos Santos Aguiar ◽  
Maria José Mastellaro ◽  
...  
Keyword(s):  
High Risk ◽  
Germ Cell ◽  
Children And Adolescents ◽  
Germ Cell Tumor ◽  
Multidisciplinary Treatment ◽  
Germ Cell Tumors ◽  
High Risk Group ◽  
Cell Tumor ◽  
Term Survival ◽  
Risk Patients

Purpose In 1988, we formed a consortium of Brazilian institutions to develop uniform standards for the diagnostic assessment and multidisciplinary treatment of children and adolescents with germ cell tumors. We also implemented the first childhood Brazilian germ cell tumor protocol, GCT-91, evaluating two-agent chemotherapy with cisplatin and etoposide (PE). We now report on the clinical characteristics and survival of children and adolescents with germ cell tumors treated on this protocol. Patients and Methods From May 1991 to April 2000, 115 patients (106 assessable patients) were enrolled onto the Brazilian protocol with a diagnosis of germ cell tumor. Results Patients were treated with surgery only (n = 35) and chemotherapy (n = 71). Important prognostic factors included stage (P = .025), surgical procedure at diagnosis according to resectability (P < .032), and abnormal lactate dehydrogenase value at diagnosis (P < .001). Conclusion The improvement in survival by the introduction of a standard protocol is an important achievement. This is of particular importance for smaller institutions with previous limited experience in the treatment of childhood germ cell tumors. In addition, the results of a two-agent regimen with PE were favorable (5-year overall survival rate is 83.3% for patients in the high-risk group [n = 36] who received PE v 58.8% for patients in the high-risk patients group who received PE plus ifosfamide, vinblastine, and bleomycin [n = 17; P = .017]). Thus for selected patients, complex three-agent regimens may not be necessary to achieve long-term survival, even for some patients with advanced disease.

Sign in / Sign up

Export Citation Format

Share Document