scholarly journals Intracranial Major Artery and Venous Sinus Thrombosis in a Young Male with MTHFR Mutation and Protein S Deficiency

2021 ◽  
pp. 744-748
Author(s):  
Dhanashree Peddawad
Keyword(s):  
Young Patient ◽  
Sinus Thrombosis ◽  
Recurrent Stroke ◽  
Young Patients ◽  
Young Male ◽  
Protein S ◽  
Protein S Deficiency ◽  
Venous Sinus Thrombosis ◽  
S Deficiency ◽  
Mthfr Mutation

This case represents a unique example of stroke in a young patient involving major venous sinuses as well as major artery in a span of 6 months. After evaluation, he was found to have an abnormal thrombophilia profile. In young patients with recurrent stroke, investigating for an abnormal thrombophilia profile is crucial.

Cerebral venous sinus thrombosis associated with protein S deficiency during pregnancy: a case report

2019 ◽  
Vol 40 (1) ◽  
pp. 135-136 ◽  
Author(s):  
Miyu Usui ◽  
Tadashi Ozawa ◽  
Younhee Kim ◽  
Takafumi Mashiko ◽  
Kosuke Matsuzono ◽  
...  
Keyword(s):  
Case Report ◽  
Sinus Thrombosis ◽  
Protein S ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Protein S Deficiency ◽  
Venous Sinus Thrombosis ◽  
S Deficiency

scholarly journals Successful endovascular recanalization of massive cerebral venous sinus thrombosis in a patient with tuberous sclerosis and protein S deficiency: a case report

2019 ◽  
Vol 2019 (7) ◽  
Author(s):  
Yasuhiro Nishiyama ◽  
Masayuki Ueda ◽  
Kanako Muraga ◽  
Takahiro Ota ◽  
Hiroshi Horikawa ◽  
...  
Keyword(s):  
Venous Thrombosis ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Sinus Thrombosis ◽  
Protein S ◽  
Cerebral Venous Sinus Thrombosis ◽  
Venous Sinus ◽  
Protein S Deficiency ◽  
Venous Sinus Thrombosis ◽  
S Deficiency

Abstract Here, we report the case of a 27-year-old woman with tuberous sclerosis complex who underwent successful endovascular intervention for cerebral venous thrombosis at the superior sagittal sinus. She had protein S deficiency and a long-term history of anemia caused by menorrhagia from uterine fibroids, possibly leading to a hypercoagulable state. Cerebral venous sinus thrombosis accounts for ~0.5–1% of all strokes. Several cases of venous thrombosis in patients with tuberous sclerosis complex and protein S or protein C deficiency have been reported, but further studies are needed to identify whether an association of this rare combination may be explained.

The Frequency of Type I Heterozygous Protein S and Protein C Deficiency in 141 Unrelated Young Patients with Venous Thrombosis

1988 ◽  
Vol 59 (01) ◽  
pp. 018-022 ◽  
Author(s):  
C L Gladson ◽  
I Scharrer ◽  
V Hach ◽  
K H Beck ◽  
J H Griffin
Keyword(s):  
Venous Thrombosis ◽  
Protein C ◽  
Antithrombin Iii ◽  
Young Patients ◽  
Protein S ◽  
Type I ◽  
Protein S Deficiency ◽  
Protein C Deficiency ◽  
Low Protein ◽  
S Deficiency

SummaryThe frequency of heterozygous protein C and protein S deficiency, detected by measuring total plasma antigen, in a group (n = 141) of young unrelated patients (<45 years old) with venous thrombotic disease was studied and compared to that of antithrombin III, fibrinogen, and plasminogen deficiencies. Among 91 patients not receiving oral anticoagulants, six had low protein S antigen levels and one had a low protein C antigen level. Among 50 patients receiving oral anticoagulant therapy, abnormally low ratios of protein S or C to other vitamin K-dependent factors were presented by one patient for protein S and five for protein C. Thus, heterozygous Type I protein S deficiency appeared in seven of 141 patients (5%) and heterozygous Type I protein C deficiency in six of 141 patients (4%). Eleven of thirteen deficient patients had recurrent venous thrombosis. In this group of 141 patients, 1% had an identifiable fibrinogen abnormality, 2% a plasminogen abnormality, and 3% an antithrombin III deficiency. Thus, among the known plasma protein deficiencies associated with venous thrombosis, protein S and protein C. deficiencies (9%) emerge as the leading identifiable associated abnormalities.

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