TRPV1, Nrf2, and COVID-19: Could Oxytocin Have a Beneficial Role to Play?

Abstract. Vitamin D is a secosteroid hormone that plays a pivotal role in several metabolic and reproductive pathways in humans. Increasing evidence supports the role of vitamin D deficiency in metabolic disturbances and infertility in women with polycystic ovary syndrome (PCOS). Indeed, supplementation with vitamin D seems to have a beneficial role on insulin resistance and endometrial receptivity. On the other hand, exceedingly high levels of vitamin D appear to play a detrimental role on oocytes development and embryo quality. In the current review, we summarize the available evidence about the topic, aiming to suggest the best supplementation strategy in women with PCOS or, more generally, in those with metabolic disturbances and infertility. Based on the retrieved data, vitamin D seems to have a beneficial role on IR, insulin sensitivity and endometrial receptivity, but high levels and incorrect timing of administration seem to have a detrimental role on oocytes development and embryo quality. Therefore, we encourage a low dose supplementation (400–800 IU/day) particularly in vitamin D deficient women that present metabolic disturbances like PCOS. As far as the reproductive health, we advise vitamin D supplementation in selected populations, only during specific moments of the ovarian cycle, to support the luteal phase. However, ambiguities about dosage and timing of the supplementation still emerge from the clinical studies published to date and further studies are required.

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Faculty Opinions recommendation of A beneficial role for immunoglobulin E in host defense against honeybee venom.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718170948.793487951 ◽

2013 ◽

Author(s):

David Voehringer

Keyword(s):

Host Defense ◽

Immunoglobulin E ◽

Honeybee Venom ◽

Beneficial Role

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I Like the Way You Eat It: Lemur (Indri indri) Gut Mycobiome and Geophagy

Microbial Ecology ◽

10.1007/s00248-020-01677-5 ◽

2021 ◽

Author(s):

Luigimaria Borruso ◽

Alice Checcucci ◽

Valeria Torti ◽

Federico Correa ◽

Camillo Sandri ◽

...

Keyword(s):

Plant Material ◽

Soil Characteristics ◽

Nutrient Supply ◽

Fungal Species ◽

High Concentration ◽

Beneficial Role ◽

Intimate Connection ◽

Indri Indri ◽

Lemur Species

AbstractHere, we investigated the possible linkages among geophagy, soil characteristics, and gut mycobiome of indri (Indri indri), an endangered lemur species able to survive only in wild conditions. The soil eaten by indri resulted in enriched secondary oxide-hydroxides and clays, together with a high concentration of specific essential micronutrients. This could partially explain the role of the soil in detoxification and as a nutrient supply. Besides, we found that soil subject to geophagy and indris’ faeces shared about 8.9% of the fungal OTUs. Also, several genera (e.g. Fusarium, Aspergillus and Penicillium) commonly associated with soil and plant material were found in both geophagic soil and indri samples. On the contrary, some taxa with pathogenic potentials, such as Cryptococcus, were only found in indri samples. Further, many saprotrophs and plant-associated fungal taxa were detected in the indri faeces. These fungal species may be involved in the digestion processes of leaves and could have a beneficial role in their health. In conclusion, we found an intimate connection between gut mycobiome and soil, highlighting, once again, the potential consequent impacts on the wider habitat.

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Does the Intradiscal Injection of Platelet Rich Plasma Have Any Beneficial Role in the Management of Lumbar Disc Disease?

Global Spine Journal ◽

10.1177/2192568221998367 ◽

2021 ◽

pp. 219256822199836

Author(s):

Sathish Muthu ◽

Madhan Jeyaraman ◽

Girinivasan Chellamuthu ◽

Naveen Jeyaraman ◽

Rashmi Jain ◽

...

Keyword(s):

Beneficial Effect ◽

Platelet Rich Plasma ◽

Lumbar Disc ◽

Meta Analysis ◽

Cochrane Library ◽

Significant Heterogeneity ◽

Disc Disease ◽

Lumbar Disc Disease ◽

Beneficial Role ◽

Sf 36

Study Design: Systematic review and meta-analysis. Objectives: We performed this meta-analysis to evaluate whether intradiscal Platelet Rich Plasma(PRP) injection has any beneficial role in the management of lumbar disc disease. Methods: We conducted independent and duplicate electronic database searches including PubMed, Embase, and Cochrane Library till September 2020 for studies investigating the role of intradiscal PRP in the management of lumbar disc disease. The analysis was performed in the R platform using OpenMeta[Analyst] software. Results: 13 studies including 2 RCTs, 5 prospective, and 6 retrospective studies involving 319 patients were included in the meta-analysis. A single-arm meta-analysis of the included studies showed a beneficial effect of the intervention in terms of pain relief outcomes like VAS score (p < 0.001), pain component of SF-36 (p = 0.003) while such improvement was not seen in functional outcome measures like ODI score (p = 0.071), the physical component of SF-36 (p = 0.130) with significant heterogeneity noted among the included studies. No structural improvement in magnetic resonance imaging was observed (p = 0.106). No additional procedure-related adverse events were noted in the included studies (p = 0.662). Conclusion: There is a paucity of high-quality studies to give conclusive evidence on the benefits of intradiscal PRP for lumbar disc disease. Although intradiscal PRP injection has shown some beneficial effect in controlling pain for lumbar disc disease, we could not find structural or functional improvement from the included studies. Hence, we recommend large double-blind double-arm randomized controlled studies to analyze the benefits of the intervention being analyzed.

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Tannic Acid as a Natural Ferroptosis Inhibitor: Mechanisms and Beneficial Role of 3’‐ O ‐Galloylation

ChemistrySelect ◽

10.1002/slct.202004392 ◽

2021 ◽

Vol 6 (7) ◽

pp. 1562-1569

Author(s):

Yangping Liu ◽

Xican Li ◽

Yujie Hua ◽

Wenhui Zhang ◽

Xianxi Zhou ◽

...

Keyword(s):

Tannic Acid ◽

Beneficial Role

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Eltrombopag and its beneficial role in management of ulcerative Colitis associated with ITP as an upfront therapy case report

Clinical Case Reports ◽

10.1002/ccr3.3783 ◽

2021 ◽

Author(s):

Elabbass A. Abdelmahmuod ◽

Elrazi Ali ◽

Mohanad A. Ahmed ◽

Mohamed A. Yassin

Keyword(s):

Ulcerative Colitis ◽

Case Report ◽

Beneficial Role ◽

Upfront Therapy

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The beneficial role of the synthetic microneurotrophin BNN20 in a focal demyelination model

Journal of Neuroscience Research ◽

10.1002/jnr.24809 ◽

2021 ◽

Vol 99 (5) ◽

pp. 1474-1495

Author(s):

Ilias Kalafatakis ◽

Alexandros Patellis ◽

Ioannis Charalampopoulos ◽

Achille Gravanis ◽

Domna Karagogeos

Keyword(s):

Beneficial Role ◽

Focal Demyelination

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A Step Toward Optimizing Regenerative Medicine Principle to Combat COVID-19

Annals of the National Academy of Medical Sciences (India) ◽

10.1055/s-0041-1731597 ◽

2021 ◽

Author(s):

Shilpa Sharma ◽

Madhan Jeyaraman ◽

Sathish Muthu ◽

Talagavadi Channaiah Anudeep ◽

Naveen Jeyaraman ◽

...

Keyword(s):

Clinical Trial ◽

Stem Cells ◽

Regenerative Medicine ◽

Large Volume ◽

Beneficial Role

AbstractDrugs are currently not licensed in specific to pulverize COVID-19. On an emergency basis, vaccines were approved to prevent the further spread of COVID-19. This serves as a potential background for considering the optimization of biologics. In this context, evidence on convalescent plasma and stem cells has shown a beneficial role. Here, we have considered this as plausible therapy, and further hypothesize that their cocktails will synergistically boost the immunogenicity to relegate COVID-19. This warrants a large volume clinical trial on an emergent basis, because the sooner we establish a safe and effective cure, the better.

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