Fibrinogen Saint-Germain II: Hypofibrinogenemia due to heterozygous γ N345S mutation
Keyword(s):
Factor V
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SummaryWe have identified a novel heterozygous fibrinogen γ chain mutation, γN345S (Fibrinogen Saint-Germain II), in a subject with hypofibrinogenemia. There was no evidence by mass spectrometry of plasma fibrinogen containing the mutant chain. The hypofibrinogenemia was discovered in a 26-year-old man who experienced extensive deep venous thrombosis of the left leg associated with pulmonary embolism. Investigation of potential thromboembolic risk factors revealed heterozygosity of the factor V R506Q mutation (factor V Leiden) and heterozygosity of the prothrombin gene G20210A mutation. The hypofibrinogenemia may be contributory to the thrombophilic manifestations.
2002 ◽
Vol 87
(04)
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pp. 580-585
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2006 ◽
Vol 28
(2)
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pp. 111-116
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Keyword(s):
2006 ◽
Vol 17
(1)
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pp. 23-28
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