γ’/total fibrinogen ratio is associated with short-term outcome in ischaemic stroke

SummaryFibrinogen γ’ (γ’) is a natural isoform of fibrinogen, and alters the rate of formation and the properties of clots. It could therefore affect outcome after ischaemic stroke. The prognostic significance of γ’ fibrinogen levels is, however, still unclear. It was the objective of this study to assess levels of γ’ in ischaemic stroke, and its association with short-term outcome. We included 200 ischaemic stroke patients and 156 control persons. Total fibrinogen and γ’ levels were measured; outcome at discharge was assessed by means of the modified Rankin Scale score (defined as unfavourable when >2). We compared levels between patients and controls using multiple linear regression analysis, and logistic regression analysis was used to assess the relationship between levels and outcome. All analyses were adjusted for age and sex. Mean γ’ levels were significantly higher in patients with ischaemic stroke than in controls (0.37 vs. 0.32 g/l, p<0.001), and patients also had a higher γ’/total fibrinogen ratio (0.102 vs. 0.096, p=0.19). The γ’/total fibrinogen ratio is associated with unfavourable outcome in patients with ischaemic stroke (odds ratio per unit increase of γ’/total fibrinogen ratio 1.27, 95% confidence interval 1.09–1.47). Our study shows that patients with ischaemic stroke have increased levels of fibrinogen γ’ and suggests a trend towards an increased γ’/total fibrinogen ratio in ischaemic stroke. Increased fibrinogen γ’ relative to total fibrinogen levels are associated with unfavourable outcome in the early phase after stroke.

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Effect Of Admission Hyperglycaemia On Short-Term Outcome In Adult Nigerians With A First Acute Ischaemic Stroke

African Journal of Neurological Sciences ◽

10.4314/ajns.v26i2.7598 ◽

2008 ◽

Vol 26 (2) ◽

Author(s):

K Wahab ◽

N Okubadejo ◽

F Ojini ◽

M Danesi

Keyword(s):

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

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Poor short-term outcome in patients with ischaemic stroke and active cancer

Journal of Neurology ◽

10.1007/s00415-015-7954-6 ◽

2015 ◽

Vol 263 (1) ◽

pp. 150-156 ◽

Cited By ~ 22

Author(s):

Markus Kneihsl ◽

Christian Enzinger ◽

Gerit Wünsch ◽

Michael Khalil ◽

Valeriu Culea ◽

...

Keyword(s):

Ischaemic Stroke ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome ◽

Active Cancer

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Effect of mHealth With Offline Antiobesity Treatment in a Community-Based Weight Management Program: Cross-Sectional Study

JMIR mhealth and uhealth ◽

10.2196/13273 ◽

2020 ◽

Vol 8 (1) ◽

pp. e13273 ◽

Cited By ~ 6

Author(s):

Youngin Kim ◽

Bumjo Oh ◽

Hyun-Young Shin

Keyword(s):

Health Care ◽

Weight Loss ◽

Regression Analysis ◽

Linear Regression ◽

Multiple Linear Regression ◽

Fat Mass ◽

Weight Change ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Short Term

Background Weight loss interventions using mobile phone apps have recently shown promising results. Objective This study aimed to analyze the short-term weight loss effect of a mobile coaching intervention when it is integrated with a local public health care center and a regional hospital’s antiobesity clinic as a multidisciplinary model. Methods A total of 150 overweight or obese adults signed up to complete an 8-week antiobesity intervention program with human coaching through a mobile platform. Paired t tests and multiple linear regression analysis were used to identify the intervention factors related to weight change. Results Among the 150 participants enrolled in this study, 112 completed the 8-week weight loss intervention. Weight (baseline: mean 77.5 kg, SD 12.9; after intervention: mean 74.8 kg, SD 12.6; mean difference −2.73 kg), body mass index, waist circumference, fat mass (baseline: mean 28.3 kg, SD 6.6; after intervention: mean 25.7 kg, SD 6.3; mean difference −2.65 kg), and fat percentage all showed a statistically significant decrease, and metabolic equivalent of task (MET) showed a statistically significant increase after intervention. In multiple linear regression analysis, age (beta=.07; P=.06), △MET (beta=−.0009; P=.10), number of articles read (beta=−.01; P=.04), and frequency of weight records (beta=−.05; P=.10; R2=0.4843) were identified as significant factors of weight change. Moreover, age (beta=.06; P=.03), sex (female; beta=1.16; P=.08), △MET (beta=−.0009; P<.001), and number of articles read (beta=−.02; P<.001; R2=0.3728) were identified as significant variables of fat mass change. Conclusions The multidisciplinary approach, combining a mobile health (mHealth) care app by health care providers, was effective for short-term weight loss. Additional studies are needed to evaluate the efficacy of mHealth care apps in obesity treatment.

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Spinal ischaemic stroke: clinical and radiological findings and short-term outcome

European Journal of Neurology ◽

10.1111/j.1468-1331.2010.02994.x ◽

2011 ◽

Vol 18 (2) ◽

pp. 232-239 ◽

Cited By ~ 49

Author(s):

E. Kumral ◽

F. Polat ◽

H. Güllüoglu ◽

C. Uzunköprü ◽

R. Tuncel ◽

...

Keyword(s):

Ischaemic Stroke ◽

Radiological Findings ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

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Progranulin and short‐term outcome in patients with acute ischaemic stroke

European Journal of Neurology ◽

10.1111/ene.12920 ◽

2016 ◽

Vol 23 (3) ◽

pp. 648-655 ◽

Cited By ~ 8

Author(s):

S. Xie ◽

L. Lu ◽

L. Liu ◽

G. Bi ◽

L. Zheng

Keyword(s):

Ischaemic Stroke ◽

Acute Ischaemic Stroke ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

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Efficacy and Safety of Single-Session Radiofrequency Ablation in Treating Benign Thyroid Nodules: A Short-Term Prospective Cohort Study

International Journal of Endocrinology ◽

10.1155/2021/7556393 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Van Bang Nguyen ◽

Thi Xuan Nguyen ◽

Van Vy Hau Nguyen ◽

Hai Thuy Nguyen ◽

Dinh Toan Nguyen ◽

...

Keyword(s):

Regression Analysis ◽

Thyroid Nodules ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Volume Reduction ◽

Short Term ◽

Therapeutic Success ◽

Benign Thyroid Nodules ◽

Benign Thyroid

Objective. The aims of this study are to evaluate the safety and efficacy of RFA in the treatment of benign thyroid nodule(s) and to find independent factors related to the volume reduction rate of the nodule(s). Materials and Methods. This short-term prospective study from a single medical center was conducted on 93 benign thyroid nodules in 93 patients treated with RFA. Two basic techniques were used: the trans-isthmic approach and moving-shot technique. Clinical and ultrasonography examinations were performed at 1- and 3-month follow-up after the treatment session. Primary outcomes included volume reduction ratio (VRR) at 1-month and 3-month follow-ups; secondary outcomes were therapeutic success rate and complications. Multiple linear regression analysis was used to determine independent factors associated with VRR. Results. A final sample of 78 patients with 78 nodules, given participant rate 83.8% (including 60 solid nodules, 16 predominantly cystic nodules, and 2 thyroid cysts), was followed up for 3 months. The mean volume reduction ratio was 41.47% and 64.72% after 1-month and 3-month follow-ups, respectively. The therapeutic success rate was 30.8% at 1-month and 84.6% at 3-month follow-ups. Symptom score and cosmetic score improved significantly. There was no change in thyroid function tests. Two minor complications (transient voice change) were found. The multiple linear regression analysis showed that the internal component of the nodules significantly related to the VRR during the 3-month follow-up (β = 23.00; 95%CI (7.59–38.45)). Conclusion. RFA was demonstrated as a safe and effective option for benign thyroid nodules treatment. It can be used as an alternative treatment with encouraging results.

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Effect of mHealth With Offline Antiobesity Treatment in a Community-Based Weight Management Program: Cross-Sectional Study (Preprint)

10.2196/preprints.13273 ◽

2019 ◽

Author(s):

Youngin Kim ◽

Bumjo Oh ◽

Hyun-Young Shin

Keyword(s):

Health Care ◽

Weight Loss ◽

Regression Analysis ◽

Linear Regression ◽

Multiple Linear Regression ◽

Fat Mass ◽

Weight Change ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Short Term

BACKGROUND Weight loss interventions using mobile phone apps have recently shown promising results. OBJECTIVE This study aimed to analyze the short-term weight loss effect of a mobile coaching intervention when it is integrated with a local public health care center and a regional hospital’s antiobesity clinic as a multidisciplinary model. METHODS A total of 150 overweight or obese adults signed up to complete an 8-week antiobesity intervention program with human coaching through a mobile platform. Paired <italic>t</italic> tests and multiple linear regression analysis were used to identify the intervention factors related to weight change. RESULTS Among the 150 participants enrolled in this study, 112 completed the 8-week weight loss intervention. Weight (baseline: mean 77.5 kg, SD 12.9; after intervention: mean 74.8 kg, SD 12.6; mean difference −2.73 kg), body mass index, waist circumference, fat mass (baseline: mean 28.3 kg, SD 6.6; after intervention: mean 25.7 kg, SD 6.3; mean difference −2.65 kg), and fat percentage all showed a statistically significant decrease, and metabolic equivalent of task (MET) showed a statistically significant increase after intervention. In multiple linear regression analysis, age (beta=.07; <italic>P</italic>=.06), △MET (beta=−.0009; <italic>P</italic>=.10), number of articles read (beta=−.01; <italic>P</italic>=.04), and frequency of weight records (beta=−.05; <italic>P</italic>=.10; <italic>R</italic><sup>2</sup>=0.4843) were identified as significant factors of weight change. Moreover, age (beta=.06; <italic>P</italic>=.03), sex (female; beta=1.16; <italic>P</italic>=.08), △MET (beta=−.0009; <italic>P</italic><.001), and number of articles read (beta=−.02; <italic>P</italic><.001; <italic>R</italic><sup>2</sup>=0.3728) were identified as significant variables of fat mass change. CONCLUSIONS The multidisciplinary approach, combining a mobile health (mHealth) care app by health care providers, was effective for short-term weight loss. Additional studies are needed to evaluate the efficacy of mHealth care apps in obesity treatment.

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Quality of rearing practices as predictor of short-term outcome in adolescent anorexia nervosa

Psychological Medicine ◽

10.1017/s0033291799001385 ◽

2000 ◽

Vol 30 (1) ◽

pp. 61-67 ◽

Cited By ~ 20

Author(s):

J. CASTRO ◽

J. TORO ◽

M. CRUZ

Keyword(s):

Logistic Regression ◽

Anorexia Nervosa ◽

Regression Analysis ◽

Logistic Regression Analysis ◽

Young Patients ◽

Eating Attitudes ◽

Appreciable Effect ◽

Short Term ◽

Term Outcome ◽

Short Term Outcome

Background. Studies of family relationships in anorexia nervosa have produced conflicting results. Some authors claim that family factors are related to short-term outcomes.Methods. Perceived rearing practices, as measured by the EMBU (Egna Minnen Betraffande Uppfostran: ‘My memories of Upbringing’) were examined in a sample (N = 158) of adolescents with anorexia nervosa and compared with the perceptions of adolescents (N = 159) from the general population. A further comparison was made between the groups of patients with good and bad short-term outcomes. Logistic regression analysis was performed to evaluate the predictive value of different variables on short-term outcome.Results. Overall, small differences were observed in the perceptions of rearing practices as expressed by the controls and the anorexic patients. Patients with bad short-term outcome perceived more rejection and control–overprotection from both parents than those with good outcome. In the logistic regression analysis only Rejection from father and the EAT (Eating Attitudes Test) total score gave independent prediction of treatment response.Conclusions. Taken as a whole, these results do not support the idea of altered rearing practices in anorexic patients, at least in young patients with a short evolution of the disease. Perceived rearing practices, especially ‘rejection’, appear to have an appreciable effect on the short-term outcome.

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Short-term, high-dose glucocorticoid treatment does not contribute to reduced bone mineral density in patients with multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458514566417 ◽

2015 ◽

Vol 21 (12) ◽

pp. 1557-1565 ◽

Cited By ~ 11

Author(s):

A Olsson ◽

DB Oturai ◽

PS Sørensen ◽

PS Oturai ◽

AB Oturai

Keyword(s):

Multiple Sclerosis ◽

Bone Mineral Density ◽

Regression Analysis ◽

Linear Regression ◽

Multiple Linear Regression ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

High Dose ◽

Mineral Density ◽

Short Term

Background: Patients with multiple sclerosis (MS) are at increased risk of reduced bone mineral density (BMD). A contributing factor might be treatment with high-dose glucocorticoids (GCs). Objectives: The objective of this paper is to assess bone mass in patients with MS and evaluate the importance of short-term, high-dose GC treatment and other risk factors that affect BMD in patients with MS. Methods: A total of 260 patients with MS received short-term high-dose GC treatment and had their BMD measured by dual x-ray absorptiometry. BMD was compared to a healthy age-matched reference population ( Z-scores). Data regarding GCs, age, body mass index (BMI), serum 25(OH)D, disease duration and severity were collected retrospectively and analysed in a multiple linear regression analysis to evaluate the association between each risk factor and BMD. Results: Osteopenia was present in 38% and osteoporosis in 7% of the study population. Mean Z-score was significantly below zero, indicating a decreased BMD in our MS patients. Multiple linear regression analysis showed no significant association between GCs and BMD. In contrast, age, BMI and disease severity were independently associated with both lumbar and femoral BMD. Conclusion: Reduced BMD was prevalent in patients with MS. GC treatment appears not to be the primary underlying cause of secondary osteoporosis in MS patients.

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