scholarly journals Clinical characteristics and treatment outcomes in acromegaly, a retrospective single-center case series from Thailand

2021 ◽  
Vol 40 ◽  
Author(s):  
Poranee Ganokroj ◽  
Sarat Sunthornyothin ◽  
Rungsak Siwanuwatn ◽  
Kraisri Chantra ◽  
Patinut Buranasupkajorn ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Clinical Characteristics ◽  
Case Series ◽  
Single Center

scholarly journals COVID-19 Vaccination in Patients with Myasthenia Gravis: A Single-Center Case Series

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1112
Author(s):  
Zhe Ruan ◽  
Yonglan Tang ◽  
Chunhong Li ◽  
Chao Sun ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptors ◽  
Subunit Vaccine ◽  
Clinical Characteristics ◽  
Case Series ◽  
Onset Age ◽  
Single Center ◽  
Inactivated Vaccines ◽  
Main Observation ◽  
The Mean

In this study, we report the safety of coronavirus disease 2019 (COVID-19) vaccine in patients with myasthenia gravis (MG). Patients who were vaccinated against COVID-19 were included. Demographics, clinical characteristics, medications, and vaccination information were collected. The main observation outcome is the worsening of MG symptoms within 4 weeks following COVID-19 vaccination. A total of 22 patients with MG vaccinated for COVID-19 were included. Ten (45.5%) patients had ocular MG (OMG), and 12 (55.5%) patients had generalized MG (GMG). Six (27.3%) patients were female, and the mean (SD) onset age was 45.4 (11.8) years. Nineteen (86.4%) patients were seropositive for acetylcholine receptors (AChR) antibody. Seven (31.8%) patients underwent thymectomy, and four of them confirmed thymoma pathologically. Twenty-one patients were administrated with inactivated vaccines, and the remaining one was administrated with recombinant subunit vaccine. Twenty (90.9%) patients did not present MG symptom worsening within 4 weeks of COVID-19 vaccination, and two (9.1%) patients reported slight symptom worsening but resolved quickly within a few days. Our findings suggest inactivated COVID-19 vaccines might be safe in MG patients with Myasthenia Gravis Foundation of America (MGFA) classification I to II, supporting the recommendation to promote vaccination for MG patients during the still expanding COVID-19 pandemic.

scholarly journals Clinical Characteristics and Treatment Outcomes of Patients with Malignant Extracranial Germ Cell Tumors: A 20-Year Single-Center Experience

2021 ◽  
Vol 19 (2) ◽  
pp. 176-184
Author(s):  
Funda Tayfun Küpesiz ◽  
Gülen Tüysüz ◽  
Ayşe Nur Akınel ◽  
Ayşegül Tekneci ◽  
Ayşe Çiğdem Sivrice ◽  
...  
Keyword(s):  
Germ Cell ◽  
Treatment Outcomes ◽  
Clinical Characteristics ◽  
Germ Cell Tumors ◽  
Single Center ◽  
Single Center Experience

scholarly journals Asymptomatic COVID-19 Have Longer Treatment Cycle Than Moderate Type of Confirmed Patients

2020 ◽  
Author(s):  
Wei Zhang ◽  
Qinying Long ◽  
Yanbiao Huang ◽  
Changju Chen ◽  
Jinhua Wu ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Treatment Cycle ◽  
Clinical Laboratory ◽  
Case Series ◽  
Interquartile Range ◽  
Control Group ◽  
Single Center ◽  
Clinical Trial Registry ◽  
The Difference ◽  
Novel Coronavirus

ABSTRACTObjectivesA kind of pneumonia caused by unknown causes that occurred in Wuhan, Hubei, China in December 2019, was reported as a result of novel coronavirus infection on January 7, 2020, and then WHO named it COVID-19. To compare the difference of epidemiology and clinical characteristics between asymptomatic COVID-19 infections and moderate type of confirmed cases.MethodsRetrospective, single-center cohort study of COVID-19 involving 52 infections of both 26 asymptomatic and 26 moderate type of confirmed cases in the recovery stage at Guizhou Provincial Staff Hospital in Guiyang, China, from January 29, to March 31, 2020; final date of follow-up was April 22. This study was registered in Chinese Clinical Trial Registry Center. Documented the asymptomatic COVID-19 infections and moderate type of confirmed cases. Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Epidemiological and clinical characteristics of asymptomatic COVID-19 infections and moderate type of confirmed cases were compared.ResultsThe median treatment cycle of asymptomatic COVID-19 infections was 16 days (interquartile range, 11-20 days) and longer than 13 days (interquartile range, 10-15 days) of moderate type of confirmed cases (p=0.049). The median incubation period of asymptomatic COVID-19 infections was 10 days (interquartile range, 0-21 days), while the control group was 7 days (interquartile range, 1-15 days) (p=0.27). On the initial chest computerized tomography (CT) check, 18 (69.2%, 18/26) asymptomatic COVID-19 infections were no imaging changes, which was of no significance compared with 12 (46.2%, 12/26) patients with moderate type of confirmed patients (p=0.092).ConclusionsIn this single-center study, we found that asymptomatic COVID-19 infections have longer treatment cycle than those moderate type of confirmed cases.Key PointsIn this single-center case series involving 52 infections with asymptomatic and moderate type of COVID-19 cases, asymptomatic COVID-19 infections have longer treatment cycle than those moderate type of confirmed patients.

scholarly journals Clinical Characteristics and Treatment Outcomes of Patients with Sternoclavicular Septic Arthritis Caused by Staphylococcus aureus

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S96-S96
Author(s):  
Byunghan Ryu ◽  
Young-Rock Jang ◽  
Seung Hyun Lee ◽  
Jeongmin Hong ◽  
Min-Chul Kim ◽  
...  
Keyword(s):  
Septic Arthritis ◽  
Treatment Outcomes ◽  
Chest Wall ◽  
Medical Therapy ◽  
Surgical Therapy ◽  
Clinical Characteristics ◽  
Case Series ◽  
Neck Abscess ◽  
Sternal Osteomyelitis ◽  
Limited Surgery

Abstract Background Aggressive surgical therapy such as en-bloc resection of the joint is favored in the treatment of sternoclavicular (SC) septic arthritis. However, this practice is based on expert opinion and small case series. We analyzed the clinical characteristics and treatment outcomes of patients with S. aureus SC septic arthritis treated with medical therapy alone or with limited surgical therapy. Methods All adult patients with SC septic arthritis caused by S. aureus at the Asan Medical Center between September 2009 and December 2016 were retrospectively reviewed. Demographic characteristics, laboratory results, underlying diseases/conditions, patient management, and treatment outcomes were assessed. SC septic arthritis due to S. aureus was defined if patients had positive cultures of specimens from the SC joint, or if blood cultures yielded S. aureus, together with physical findings and imaging studies supporting the diagnosis of SC septic arthritis. Limited surgical therapy was defined as simple incision, drainage, and debridement of infected SC joint. Results In total, 22 cases of S. aureus SC septic arthritis were enrolled. Of these 22 patients, 11 received medical therapy alone, 11 underwent limited surgical therapy, and none underwent aggressive surgery. Most patients (73%) had underlying predisposing conditions such as infection at a distant site, diabetes, and liver cirrhosis, and none had IV drug abuse or HIV infection. Complications such as chest wall and/or neck abscess, clavicular and/or sternal osteomyelitis were identified in 18 patients (82%). Patients with chest wall and/or neck abscess had a tendency to be treated with limited surgery than patients without them (73% vs. 27%, P = 0.09). The median duration of intravenous antibiotics in all patients was 35 days (IQR 25–46 days). After a median follow-up of 31 months (IQR 2–40 months), there was no relapse of SC septic arthritis or deterioration of joint function. Conclusion Medical therapy alone or with limited surgical therapy appears to be a successful therapeutic strategy for the complicated S. aureus SC septic arthritis in a selected patient. Disclosures All authors: No reported disclosures.

Retrospective Study on Clinical Features and Treatment Outcomes of Nontraumatic Inguinal Hernias in 41 Dogs

2020 ◽  
Vol 56 (6) ◽  
pp. 301
Author(s):  
Teruo Itoh ◽  
Atsuko Kojimoto ◽  
Kentaro Kojima ◽  
Hiroki Shii
Keyword(s):  
Small Intestine ◽  
Treatment Outcomes ◽  
Medical Records ◽  
Clinical Characteristics ◽  
Case Series ◽  
Long Term Results ◽  
Inguinal Hernias ◽  
Small Intestines ◽  
Resection And Anastomosis

ABSTRACT Several factors are suggested to be involved in the development of nontraumatic inguinal hernias (NTIHs) in dogs, but case series studies focusing on the etiology and treatment outcomes are limited. The aim of this study was to retrospectively evaluate the clinical characteristics and treatment outcomes of NTIHs in dogs. Medical records of 42 dogs with surgically treated NTIHs were reviewed. Forty-one dogs were included in the study, all dogs were small breeds weighing <10 kg, and middle to older age (>5 yr old; 33 cases), female sex (34 cases), and miniature dachshunds (26 cases) predominated. Left-sided occurrence was common (30 left, 9 right, 2 bilateral), and organ protrusion was seen in 22 cases (15 uteri, 9 small intestines, 1 colon). Fourteen of 15 uterine herniations (93%) were located left side. Ovariohysterectomy was performed with herniorrhaphy in 27/30 intact bitches, two of whom also underwent resection and anastomosis of a devitalized portion of the small intestine. Recurrence was seen in only one male dog. These results suggest that NTIHs are more likely to occur in small-breed female dogs, and that age may increase the risk of left-sided uterine protrusion; however, the long-term results after herniorrhaphy with ovariohysterectomy are excellent.

scholarly journals Clinical Characteristics of Patients With Coronavirus Disease 2019 in Japan: A Single-Center Case Series

2020 ◽  
Vol 222 (2) ◽  
pp. 194-197 ◽  
Author(s):  
Ken-ichiro Kobayashi ◽  
Takahiro Kaki ◽  
Shinsuke Mizuno ◽  
Kenji Kubo ◽  
Nobuhiro Komiya ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Polymerase Chain Reaction ◽  
Clinical Characteristics ◽  
Case Series ◽  
Ground Glass ◽  
Single Center ◽  
Chain Reaction ◽  
Pharyngeal Swab ◽  
Polymerase Chain

Abstract We report a case series of 6 patients with confirmed coronavirus disease 2019 (COVID-19) in Wakayama prefecture, Japan. All 6 of the patients tested positive via pharyngeal swab polymerase chain reaction (PCR) tests, and 2 of the 6 were still positive at 3 weeks after onset. All of the patients exhibited bilateral ground glass opacities on computed tomography (CT). This article also reports narrative information on the spectrum of symptoms collected directly from the patients. It would be difficult to triage patients with COVID-19 based on the typical symptoms of fever and/or cough, although PCR and CT are definitive in diagnosis.

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