Clinical Characteristics of Anti-PL-12 Antibody-Positive Interstitial Pneumonia: A Single-Center Case Series

2019 ◽  
Author(s):  
M. Asaoka ◽  
H. Kitamura ◽  
K. Isomoto ◽  
H. Okabayashi ◽  
A. Sekine ◽  
...  
Keyword(s):  
Interstitial Pneumonia ◽  
Clinical Characteristics ◽  
Case Series ◽  
Single Center

scholarly journals COVID-19 Vaccination in Patients with Myasthenia Gravis: A Single-Center Case Series

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1112
Author(s):  
Zhe Ruan ◽  
Yonglan Tang ◽  
Chunhong Li ◽  
Chao Sun ◽  
Ying Zhu ◽  
...  
Keyword(s):  
Myasthenia Gravis ◽  
Acetylcholine Receptors ◽  
Subunit Vaccine ◽  
Clinical Characteristics ◽  
Case Series ◽  
Onset Age ◽  
Single Center ◽  
Inactivated Vaccines ◽  
Main Observation ◽  
The Mean

In this study, we report the safety of coronavirus disease 2019 (COVID-19) vaccine in patients with myasthenia gravis (MG). Patients who were vaccinated against COVID-19 were included. Demographics, clinical characteristics, medications, and vaccination information were collected. The main observation outcome is the worsening of MG symptoms within 4 weeks following COVID-19 vaccination. A total of 22 patients with MG vaccinated for COVID-19 were included. Ten (45.5%) patients had ocular MG (OMG), and 12 (55.5%) patients had generalized MG (GMG). Six (27.3%) patients were female, and the mean (SD) onset age was 45.4 (11.8) years. Nineteen (86.4%) patients were seropositive for acetylcholine receptors (AChR) antibody. Seven (31.8%) patients underwent thymectomy, and four of them confirmed thymoma pathologically. Twenty-one patients were administrated with inactivated vaccines, and the remaining one was administrated with recombinant subunit vaccine. Twenty (90.9%) patients did not present MG symptom worsening within 4 weeks of COVID-19 vaccination, and two (9.1%) patients reported slight symptom worsening but resolved quickly within a few days. Our findings suggest inactivated COVID-19 vaccines might be safe in MG patients with Myasthenia Gravis Foundation of America (MGFA) classification I to II, supporting the recommendation to promote vaccination for MG patients during the still expanding COVID-19 pandemic.

scholarly journals Asymptomatic COVID-19 Have Longer Treatment Cycle Than Moderate Type of Confirmed Patients

2020 ◽  
Author(s):  
Wei Zhang ◽  
Qinying Long ◽  
Yanbiao Huang ◽  
Changju Chen ◽  
Jinhua Wu ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Treatment Cycle ◽  
Clinical Laboratory ◽  
Case Series ◽  
Interquartile Range ◽  
Control Group ◽  
Single Center ◽  
Clinical Trial Registry ◽  
The Difference ◽  
Novel Coronavirus

ABSTRACTObjectivesA kind of pneumonia caused by unknown causes that occurred in Wuhan, Hubei, China in December 2019, was reported as a result of novel coronavirus infection on January 7, 2020, and then WHO named it COVID-19. To compare the difference of epidemiology and clinical characteristics between asymptomatic COVID-19 infections and moderate type of confirmed cases.MethodsRetrospective, single-center cohort study of COVID-19 involving 52 infections of both 26 asymptomatic and 26 moderate type of confirmed cases in the recovery stage at Guizhou Provincial Staff Hospital in Guiyang, China, from January 29, to March 31, 2020; final date of follow-up was April 22. This study was registered in Chinese Clinical Trial Registry Center. Documented the asymptomatic COVID-19 infections and moderate type of confirmed cases. Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Epidemiological and clinical characteristics of asymptomatic COVID-19 infections and moderate type of confirmed cases were compared.ResultsThe median treatment cycle of asymptomatic COVID-19 infections was 16 days (interquartile range, 11-20 days) and longer than 13 days (interquartile range, 10-15 days) of moderate type of confirmed cases (p=0.049). The median incubation period of asymptomatic COVID-19 infections was 10 days (interquartile range, 0-21 days), while the control group was 7 days (interquartile range, 1-15 days) (p=0.27). On the initial chest computerized tomography (CT) check, 18 (69.2%, 18/26) asymptomatic COVID-19 infections were no imaging changes, which was of no significance compared with 12 (46.2%, 12/26) patients with moderate type of confirmed patients (p=0.092).ConclusionsIn this single-center study, we found that asymptomatic COVID-19 infections have longer treatment cycle than those moderate type of confirmed cases.Key PointsIn this single-center case series involving 52 infections with asymptomatic and moderate type of COVID-19 cases, asymptomatic COVID-19 infections have longer treatment cycle than those moderate type of confirmed patients.

scholarly journals Clinical Characteristics of Patients With Coronavirus Disease 2019 in Japan: A Single-Center Case Series

2020 ◽  
Vol 222 (2) ◽  
pp. 194-197 ◽  
Author(s):  
Ken-ichiro Kobayashi ◽  
Takahiro Kaki ◽  
Shinsuke Mizuno ◽  
Kenji Kubo ◽  
Nobuhiro Komiya ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Polymerase Chain Reaction ◽  
Clinical Characteristics ◽  
Case Series ◽  
Ground Glass ◽  
Single Center ◽  
Chain Reaction ◽  
Pharyngeal Swab ◽  
Polymerase Chain

Abstract We report a case series of 6 patients with confirmed coronavirus disease 2019 (COVID-19) in Wakayama prefecture, Japan. All 6 of the patients tested positive via pharyngeal swab polymerase chain reaction (PCR) tests, and 2 of the 6 were still positive at 3 weeks after onset. All of the patients exhibited bilateral ground glass opacities on computed tomography (CT). This article also reports narrative information on the spectrum of symptoms collected directly from the patients. It would be difficult to triage patients with COVID-19 based on the typical symptoms of fever and/or cough, although PCR and CT are definitive in diagnosis.

scholarly journals CLINICAL CHARACTERISTICS AND OUTCOME OF HERPES ZOSTER IN SOLID ORGAN TRANSPLANT PATIENTS: A SINGLE CENTER CASE SERIES

2020 ◽  
Vol 104 (S3) ◽  
pp. S327-S327
Author(s):  
Cemile Tugba Altunel ◽  
Deniz Seckin ◽  
Burak Sayin ◽  
Atilla Sezgin ◽  
Aydincan Akdur ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Clinical Characteristics ◽  
Organ Transplant ◽  
Case Series ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Single Center ◽  
Transplant Patients

scholarly journals The Clinical Characteristics of Early Cases with 2019 Novel Coronavirus Disease in Tabriz, Iran

2021 ◽  
Author(s):  
Elnaz Asghari ◽  
Farnaz Rahmani ◽  
Mina Hosseinzadeh ◽  
Nader Mahdavi ◽  
Anna Praskova ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Small Sample Size ◽  
Case Series ◽  
Small Sample ◽  
Current Evidence ◽  
Common Symptom ◽  
Shortness Of Breath ◽  
Single Center ◽  
Single Center Study ◽  
Center Study

Background and Purpose: COVID-19 is a new infectious-disease first identified in December 2019 in China, and since it spread globally, it resulted in a Pandemic. Much research is needed to understand the disease, and especially its clinical characteristics. The aim of present study was to explore the clinical features, diagnosis, and treatment of COVID-19 in Tabriz, Iran. Materials and Methods: This was a case series single center study that focused retrospectively on the clinical characteristics of 140 early consecutive cases with confirmed COVID-19, who were hospitalized at one of the referral hospitals for COVID-19 patients of Tabriz, from March 20 to May 3, 2020. We used patients’ records to obtain the data, which were analyzed by SPSS Version 16 using descriptive and analytic statistics (Student’s t-test, Mann-Whitney’s, and Chi-square test). Results: Findings showed that 34 out of 140 patients deceased. The highest percentage of patients were in the age range of 65 years and over. The most common symptom on admission was dry-cough (67.9%), followed by shortness of breath (55.7%), and fever (51.5%). During hospitalization, 27.1% showed an increase in white-blood-cell count. Only 20% were ventilated and others received oxygen by cannula, and/or mask. Recovered patients reported significant lower rates of pre-existing comorbid conditions than patients who died (p= .02).  Conclusion: This single center study with a relatively small sample size showed that the most common symptom on admission among patients with COVID-19 was dry-cough, shortness of breath, and fever. The finding is mostly in accordance with the current evidence seen around the World.

scholarly journals Clinical characteristics and treatment outcomes in acromegaly, a retrospective single-center case series from Thailand

2021 ◽  
Vol 40 ◽  
Author(s):  
Poranee Ganokroj ◽  
Sarat Sunthornyothin ◽  
Rungsak Siwanuwatn ◽  
Kraisri Chantra ◽  
Patinut Buranasupkajorn ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Clinical Characteristics ◽  
Case Series ◽  
Single Center

Clinical characteristics of a novel “Type 3” vasa previa: case series at a single center

2021 ◽  
pp. 1-7
Author(s):  
Kyosuke Kamijo ◽  
Tsutomu Miyamoto ◽  
Hirofumi Ando ◽  
Yasuhiro Tanaka ◽  
Norihiko Kikuchi ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Case Series ◽  
Single Center ◽  
Vasa Previa ◽  
Type 3

scholarly journals Leukopenia of Asymptomatic COVID-19 Infections under 18 Years Old in Recovery Stage

2020 ◽  
Author(s):  
Wei Zhang ◽  
Youshu Yuan ◽  
Zhengqiao Yang ◽  
Jinxia Fu ◽  
Yun Zhang ◽  
...  
Keyword(s):  
Treatment Period ◽  
Clinical Characteristics ◽  
Clinical Laboratory ◽  
Case Series ◽  
World Health ◽  
Single Center ◽  
Recovery Stage ◽  
Familial Cluster ◽  
Asymptomatic Infections ◽  
Novel Coronavirus

ABSTRACTObjectivesIn December, 2019, a type of novel coronavirus which was designated novel coronavirus 2019 (2019-nCoV) by World Health Organization (WHO) occurred in Wuhan, Hubei, China. The epidemiological and clinical characteristics of those patients under 18 years old in the recovery stage are limited. To compare the difference of epidemiological and clinical characteristics of COVID-19 involving 25 patients under 18 years old in recovery stage between confirmed and asymptomatic infections.MethodsRetrospective, single-center cohort study of COVID-19 involving 25 patients under 18 years old in the recovery stage at Guizhou Provincial Staff Hospital in Guiyang, China, from January 29, to March 31, 2020; final date of follow-up was April 22. Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Epidemiological and clinical characteristics of confirmed COVID-19 infections and asymptomatic infections were compared.ResultsAmong the 25 COVID infections under 18 years old, 16 (64%) were mild or moderate confirmed cases, and 9 (36%) were asymptomatic. The shortest treatment period was 6 days, the longest 26 days, and the average treatment period 14 days. Four cases (44.4%) had visited Wuhan or had a living story in the city. There were 9 (100%) asymptomatic cases were familial cluster outbreak, with an average infection number was 6 cases among all families. The number of asymptomatic COVID-19 infections with leukopenia were significantly more than confirmed cases (p=0.04).ConclusionsLeukopenia mostly occurred in asymptomatic COVID-19 infections under 18 years old compared with the confirmed patients.Key PointIn this single-center case series involving 25 cases under 18 years old with COVID-19 infections, leukopenia mostly occurred in asymptomatic infections.

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