Evaluation and Comparison of Human Chorionic Amniotic Membrane and Platelet-Rich Fibrin in Achieving Bone Formation and Soft Tissue Healing in Extraction Sockets Indicated for Rehabilitation with Implants: A Preliminary Study

Rotator cuff disorders are the most common source of shoulder problems, ranging from mild strain to massive tears. Platelet-rich plasma (PRP), an autologous blood with platelets concentration above baseline values represents a source of multiple growth factors that promotes tissue repair. This review examines the potential of using PRP to augment rotator cuff repair. Reporting 4 patients with impingement syndrome and supraspinatus tear who underwent decompression acromioplasty and supraspinatus repair augmented with platelet-rich plasma and amniotic membrane. An evaluation was made 3-24 months postoperative using Shoulder Pain and Disability Index (SPADI). Average preoperative pain score is 64%, disability score 54.58%, and total score 58.19%. Average postoperative pain score is 0%, disability score 0.42%, and total score 0.26% (Minimum Detectable Change at 90% confidence for pain score is 18%, disability score 13%, and total score 11%). This result is consequent with research by Luoay Fallouh, stating that improvement is caused by growth factor effects in platelet-rich plasma which promotes soft tissue healing. It can be concluded that platelet-rich plasma and amniotic membrane have promising effects to enhance soft tissue healing in patients with rotator cuff syndrome. Shoulder function is restored with no limitation on daily activity and pain is no longer present.

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COMPARISON OF POST EXTRACTION SOCKET HEALING WITH AND WITHOUT USING PLATELET RICH FIBRIN (PRF) – A CLINICAL AND RADIOGRAPHIC STUDY

10.36106/ijsr/0702367 ◽

2021 ◽

pp. 62-65

Author(s):

S.P. Indra Kumar ◽

Kavin T ◽

Narendar R ◽

E. Gayathri Priyadharshini ◽

Akshaya murugan ◽

...

Keyword(s):

Soft Tissue ◽

Maxillofacial Surgery ◽

Test Group ◽

Control Group ◽

Oral And Maxillofacial Surgery ◽

Soft Tissue Healing ◽

Extraction Socket ◽

Platelet Rich Fibrin ◽

Tissue Healing ◽

Socket Healing

AIM: The aim of this study is to comparatively evaluate the post extraction socket healing clinically and radiographically with and without using Platelet Rich Fibrin (PRF). MATERIALS AND METHODS: Fifty, otherwise healthy individuals undergoing dental treatment in the department of Oral and Maxillofacial surgery, Vivekananda Dental College for women, Thiruchengode, were randomly selected and the participants were divided into two groups – test group(PRF, n=25) and control group (Blood clot, n=25). Blood was freshly obtained from the participants of the test group and PRF was prepared. PRF was placed in the sockets of the test group and followed by the pressure application and suturing. Control group were allowed to heal naturally. Clinically, soft tissue healing and socket closure were assessed. Radiographic analysis of socket healing done by comparison of pre- and post-operative radiographs. The clinical follow-up assessments were done at an interval of 3 days, 1 week and 4 weeks and the data obtained were assessed. The patients were aged above 18 years, i RESULT: ncluding 33 females and 17 males. The soft tissue and socket healing were higher in the test group when compared with the control group clinically and the mean proportion of radiographic bone ll was signicantly higher in the test group in all the time intervals of 3 days, 1 week and 4 weeks, respectively. Outcome of the study CONCLUSION: demonstrate that the PRF placement in the extraction socket accelerates soft tissue healing and socket healing and increases the bone ll and reduces the bone resorption using clinical and radiographic methods.

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Cryopreserved Amniotic Membrane for Modulation of Periodontal Soft Tissue Healing: A Pilot Study

Journal of Periodontology ◽

10.1902/jop.2010.100060 ◽

2010 ◽

Vol 81 (12) ◽

pp. 1797-1804 ◽

Cited By ~ 19

Author(s):

Ines Velez ◽

William B. Parker ◽

Michael A. Siegel ◽

Maria Hernandez

Keyword(s):

Pilot Study ◽

Soft Tissue ◽

Amniotic Membrane ◽

Soft Tissue Healing ◽

Tissue Healing

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Effects of Nonsteroidal Anti-Inflammatory Drugs on Bone Formation and Soft-Tissue Healing

Journal of the American Academy of Orthopaedic Surgeons ◽

10.5435/00124635-200405000-00001 ◽

2004 ◽

Vol 12 (3) ◽

pp. 139-143 ◽

Cited By ~ 111

Author(s):

Laurence E. Dahners ◽

Brian H. Mullis

Keyword(s):

Soft Tissue ◽

Bone Formation ◽

Soft Tissue Healing ◽

Tissue Healing ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Does Platelet-Rich Fibrin Decrease Dimensional Changes and Improve Postoperative Comfort in Post-Extraction Sockets? An Overview of Systematic Reviews

Applied Sciences ◽

10.3390/app10175750 ◽

2020 ◽

Vol 10 (17) ◽

pp. 5750 ◽

Cited By ~ 1

Author(s):

Vittorio Moraschini ◽

Carlos Fernando de Almeida Barros Mourão ◽

Rafael Coutinho de Mello Machado ◽

Jhonathan Raphaell Barros Nascimento ◽

Kayvon Javid ◽

...

Keyword(s):

Soft Tissue ◽

Bone Regeneration ◽

Systematic Reviews ◽

Selection Process ◽

Soft Tissue Healing ◽

Socket Preservation ◽

Platelet Rich Fibrin ◽

Dimensional Changes ◽

Tissue Healing ◽

The Impact

This overview aimed to evaluate the methods, quality, and outcomes of systematic reviews (SRs) conducted to investigate the effects of platelet-rich fibrin (PRF) in dental sockets on promoting bone regeneration and soft tissue healing and diminishing the incidence of pain, swelling, trismus, and alveolar osteitis after tooth extraction. An electronic search without date or language restriction was done in PubMed/MEDLINE, Cochrane, and Web of Science until March 2020. Eligibility criteria included SRs that assessed the effect of PRF for human alveolar socket preservation. The quality assessment of the included studies was performed using AMSTAR 2 guidelines. The protocol of this overview was recorded in PROSPERO under the number CRD42018089617. The search and selection process yielded 13 studies published between 2011 and 2018. The analysis of the studies showed inconclusive data for the effect of the PRF and the dimensional changes. There is no definitive evidence for the impact of using PRF alone on bone regeneration in post-extraction sockets. The use of PRF improves soft tissue healing and reduces pain, bleeding, and osteitis in post-extraction sockets.

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O040: Randomized clinical trial comparing two resorbable collagen membranes demonstrates good bone formation and soft tissue healing with GBR at single implant sites with dehiscence defects

Journal Of Clinical Periodontology ◽

10.1111/jcpe.39_12913 ◽

2018 ◽

Vol 45 ◽

pp. 19-20

Keyword(s):

Clinical Trial ◽

Soft Tissue ◽

Bone Formation ◽

Randomized Clinical Trial ◽

Soft Tissue Healing ◽

Tissue Healing ◽

Collagen Membranes ◽

Single Implant

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Effect of Sarang Semut Plant Extract (Myrmecodia Pendens) on wound healing of extracted tooth socket in Sprague Dawley rats

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v15i1.1359 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Bo Bo Ko ◽

Widya Lestari ◽

Alfi Khatib ◽

Haszelini Hassan ◽

Aung Gyi

Keyword(s):

Wound Healing ◽

Soft Tissue ◽

Bone Formation ◽

Male Rats ◽

Sprague Dawley ◽

Soft Tissue Healing ◽

Tooth Socket ◽

Tissue Healing ◽

Sprague Dawley Rats ◽

Healing Score

Introduction: Sarang semut (Myrmecodia Pendens) is a well-known traditional medication used by indigenous people of Papua for many diseases such as cancer, rheumatism, and ulcers. However, scientific publication of its curative properties is still lacking. This study was designed to investigate the effect of sarang semut extract on the healing process of tooth socket in Sprague Dawley rats. Methods: Thirty six adult male rats were randomly divided into six groups of six animals each. Group 1 served as a control group (no extraction). While Group 2 and 3 served as a negative control and positive control respectively. Immediately after the extraction of the right lower first molar tooth, the alveolar socket was treated with 1.5% sarang semut paste (SSP) (Group 4), 3% SSP (Group 5) and 5% SSP (Group 6). Two rats from each group were sacrificed at day 4, 7 and 18 consecutively. The extracted tooth socket was sectioned and stained with H&E stains. Soft tissue healing score of ≥ 16 indicates good healing has occurred. Whereas new bone formation of grade 2 and 3 indicates a fair and good percentage of newly deposited bone formation, respectively. Results: Histological analysis showed that soft tissue healing score for 3% SSP groups was highest (mean=19) when compared to all groups at day 18 after tooth extraction. All groups showed a good increase in the amount of bone trabeculae formed with mean grade of 2. Conclusions: This finding suggests that 3% SSP has a promising therapeutic effect on soft tissue intraoral wound healing.

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The Effectiveness of Advanced Platelet-Rich Fibrin in comparison with Leukocyte-Platelet-Rich Fibrin on Outcome after Dentoalveolar Surgery

International Journal of Dentistry ◽

10.1155/2021/6686857 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Alaa Z. Makki ◽

Anoud M. Alsulami ◽

Arwa S. Almatrafi ◽

Moroj Z. Sindi ◽

Shahinaz N. Sembawa

Keyword(s):

Soft Tissue ◽

Tooth Extraction ◽

Control Group ◽

Soft Tissue Healing ◽

Control Groups ◽

Platelet Rich Fibrin ◽

Healing Index ◽

Tissue Healing ◽

Surgical Extraction ◽

And Control

Background and Purpose. Some physiological changes may occur following tooth extraction, and symptoms during the postextraction period may affect the patient’s quality of life. Many techniques have been developed to improve postextraction pain and soft tissue healing. Accordingly, this study will compare the postextraction pain and early soft tissue healing characteristics of extraction sites treated with leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF). The aim is to evaluate the effect of advanced PRF in comparison with L-PRF on soft tissue healing and pain after teeth extraction and to advice dental practitioner to use the advanced PRF in clinic to enhance soft tissue healing and decrease pain. Methods. The study included 60 patients according to sample size calculation, recruited from patients seeking tooth extraction at oral and maxillofacial surgery clinic at Umm Al-Qura University, Faculty of Dentistry. Patients were divided into three groups. Group Ӏ included 20 patients managed by advanced platelet-rich fibrin after extraction. Group ӀӀ included 20 patients managed by leukocyte-platelet-rich fibrin after tooth extraction. Group ӀII included 20 patients left without any addition. Each group was further subdivided into surgical and nonsurgical extraction. Afterwards, patients in each group were assessed for postextraction pain by VAS, number of analgesics, and early soft tissue healing by LWHI. Results. The study outcomes demonstrate that the use of A-PRF significantly reduces postoperative pain in the 1st and 2nd day. VAS pain scores on the first day were significantly higher in the control surgical extraction group and L-PRF nonsurgical extraction group. In early soft tissue healing. The Landry Wound Healing Index (LWHI) was used after 1 and 2 weeks of extraction to evaluate the extraction site. In first week, the A-PRF group and L-PRF group (nonsurgical extraction) had a better healing index when compared to control group, and A-PRF group (surgical extraction) had a best healing index when compared to L-PRF and control groups. In the second week, individuals in the A-PRF group (surgical and nonsurgical extraction) had a better healing index when compared to L-PRF and control groups.

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