scholarly journals The Effectiveness of Advanced Platelet-Rich Fibrin in comparison with Leukocyte-Platelet-Rich Fibrin on Outcome after Dentoalveolar Surgery

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Alaa Z. Makki ◽  
Anoud M. Alsulami ◽  
Arwa S. Almatrafi ◽  
Moroj Z. Sindi ◽  
Shahinaz N. Sembawa
Keyword(s):  
Soft Tissue ◽  
Tooth Extraction ◽  
Control Group ◽  
Soft Tissue Healing ◽  
Control Groups ◽  
Platelet Rich Fibrin ◽  
Healing Index ◽  
Tissue Healing ◽  
Surgical Extraction ◽  
And Control

Background and Purpose. Some physiological changes may occur following tooth extraction, and symptoms during the postextraction period may affect the patient’s quality of life. Many techniques have been developed to improve postextraction pain and soft tissue healing. Accordingly, this study will compare the postextraction pain and early soft tissue healing characteristics of extraction sites treated with leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF). The aim is to evaluate the effect of advanced PRF in comparison with L-PRF on soft tissue healing and pain after teeth extraction and to advice dental practitioner to use the advanced PRF in clinic to enhance soft tissue healing and decrease pain. Methods. The study included 60 patients according to sample size calculation, recruited from patients seeking tooth extraction at oral and maxillofacial surgery clinic at Umm Al-Qura University, Faculty of Dentistry. Patients were divided into three groups. Group Ӏ included 20 patients managed by advanced platelet-rich fibrin after extraction. Group ӀӀ included 20 patients managed by leukocyte-platelet-rich fibrin after tooth extraction. Group ӀII included 20 patients left without any addition. Each group was further subdivided into surgical and nonsurgical extraction. Afterwards, patients in each group were assessed for postextraction pain by VAS, number of analgesics, and early soft tissue healing by LWHI. Results. The study outcomes demonstrate that the use of A-PRF significantly reduces postoperative pain in the 1st and 2nd day. VAS pain scores on the first day were significantly higher in the control surgical extraction group and L-PRF nonsurgical extraction group. In early soft tissue healing. The Landry Wound Healing Index (LWHI) was used after 1 and 2 weeks of extraction to evaluate the extraction site. In first week, the A-PRF group and L-PRF group (nonsurgical extraction) had a better healing index when compared to control group, and A-PRF group (surgical extraction) had a best healing index when compared to L-PRF and control groups. In the second week, individuals in the A-PRF group (surgical and nonsurgical extraction) had a better healing index when compared to L-PRF and control groups.

scholarly journals Influence of Leukocyte- and Platelet-Rich Fibrin (L-PRF) in the Healing of Simple Postextraction Sockets: A Split-Mouth Study

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Gaetano Marenzi ◽  
Francesco Riccitiello ◽  
Mariano Tia ◽  
Alessandro di Lauro ◽  
Gilberto Sammartino
Keyword(s):  
Soft Tissue ◽  
Healing Process ◽  
Mean Value ◽  
Soft Tissue Healing ◽  
Platelet Rich Fibrin ◽  
Healing Index ◽  
Tissue Healing ◽  
The Mean ◽  
And Control ◽  
Tooth Extractions

The aim of this study was to evaluate the effects of leukocyte- and platelet-rich fibrin (L-PRF) on the pain and soft tissue healing after tooth extractions. Twenty-six patients (9 males and 17 females) were treated with multiple extractions (2 to 8), with a total of 108 extractions. This was an exploratory single blinded randomized clinical trial with a split-mouth design. The pain after the surgery was assessed in each patient by the VAS scale (1 to 10) at intervals of 24-48-72-96 hours. The soft tissue healing was clinically evaluated at 3, 7, 14, and 21 days after surgery by the same examiner surgeon, using the modified Healing Index (4 to 12). The mean value of postextraction pain was 3.2 ± 0.3 in the experimental sides and 4.1 ± 0.1 in the control sides. After 7 days from the extractions, the values of modified Healing Index in the experimental and control groups were, respectively, 4.8 ± 0.6 and 5.1 ± 0.9. The use of L-PRF in postextraction sockets filling can be proposed as a useful procedure in order to manage the postoperative pain and to promote the soft tissue healing process, reducing the early adverse effects of the inflammation.

COMPARISON OF POST EXTRACTION SOCKET HEALING WITH AND WITHOUT USING PLATELET RICH FIBRIN (PRF) – A CLINICAL AND RADIOGRAPHIC STUDY

2021 ◽  
pp. 62-65
Author(s):  
S.P. Indra Kumar ◽  
Kavin T ◽  
Narendar R ◽  
E. Gayathri Priyadharshini ◽  
Akshaya murugan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Maxillofacial Surgery ◽  
Test Group ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Soft Tissue Healing ◽  
Extraction Socket ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Socket Healing

AIM: The aim of this study is to comparatively evaluate the post extraction socket healing clinically and radiographically with and without using Platelet Rich Fibrin (PRF). MATERIALS AND METHODS: Fifty, otherwise healthy individuals undergoing dental treatment in the department of Oral and Maxillofacial surgery, Vivekananda Dental College for women, Thiruchengode, were randomly selected and the participants were divided into two groups – test group(PRF, n=25) and control group (Blood clot, n=25). Blood was freshly obtained from the participants of the test group and PRF was prepared. PRF was placed in the sockets of the test group and followed by the pressure application and suturing. Control group were allowed to heal naturally. Clinically, soft tissue healing and socket closure were assessed. Radiographic analysis of socket healing done by comparison of pre- and post-operative radiographs. The clinical follow-up assessments were done at an interval of 3 days, 1 week and 4 weeks and the data obtained were assessed. The patients were aged above 18 years, i RESULT: ncluding 33 females and 17 males. The soft tissue and socket healing were higher in the test group when compared with the control group clinically and the mean proportion of radiographic bone ll was signicantly higher in the test group in all the time intervals of 3 days, 1 week and 4 weeks, respectively. Outcome of the study CONCLUSION: demonstrate that the PRF placement in the extraction socket accelerates soft tissue healing and socket healing and increases the bone ll and reduces the bone resorption using clinical and radiographic methods.

scholarly journals Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Sarah Al-Maawi ◽  
Kathrin Becker ◽  
Frank Schwarz ◽  
Robert Sader ◽  
Shahram Ghanaati
Keyword(s):  
Wound Healing ◽  
Soft Tissue ◽  
Tooth Extraction ◽  
Meta Analysis ◽  
Platelet Rich Fibrin ◽  
Hand Search ◽  
Healing Period ◽  
Thomson Reuters ◽  
Tissue Healing ◽  
Pubmed Database

Abstract Purpose To address the focused question: in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment? Methods After an electronic data search in PubMed database, the Web of Knowledge of Thomson Reuters and hand search in the relevant journals, a total of 20 randomized and/or controlled studies were included. Results 66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1–3 days after tooth extraction. Soft tissue healing was significantly improved in the group of PRF compared to the spontaneous wound healing after 1 week (75% of the evaluated studies). Dimensional bone loss was significantly lower in the PRF group compared to the spontaneous wound healing after 8–15 weeks but not after 6 months. Socket fill was in 85% of the studies significantly higher in the PRF group compared to the spontaneous wound healing. Conclusions Based on the analyzed studies, PRF is most effective in the early healing period of 2–3 months after tooth extraction. A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed.

scholarly journals Magnetic Resonance Imaging Findings of the Proximal Metacarpal Region in Warmblood Horses: 36 Lame and 26 Control Limbs (2015–2021)

2021 ◽  
Vol 8 ◽  
Author(s):  
Elisabeth van Veggel ◽  
Kurt Selberg ◽  
Brenda van der Velde-Hoogelander ◽  
Nick Bolas ◽  
Katrien Vanderperren ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Return To Work ◽  
Clinical Importance ◽  
Time Frame ◽  
Control Group ◽  
Dorsal Margin ◽  
Control Groups ◽  
Suspensory Ligament ◽  
Tissue Abnormalities ◽  
And Control

Objectives: This study aims to evaluate the distribution and severity of bone and soft tissue lesions in the proximal metacarpal region of warmblood horses in lame and control groups. Correlation between lesions and ability to return to work was evaluated in the lame group.Methods: This restrospective analysis evaluated 62 horses with MRI examination of the proximal metacarpal region between Sept 2015 and Feb 2021. There were 36 lame limbs and 26 control limbs. The control group included seven contralateral limbs.Results: Proximal suspensory ligament (PSL) size was not different between the lame and control groups. Hyperintensity seen on T1W/T2*W GRE images within the dorsal collagenous part of the PSL and hyperintense Short-TI Inversion Recovery (STIR) signal within the dorsal collagenous part of the PSL or within the McIII were only present within the lame group. Palmar cortical McIII resorption and dorsal margin irregularity of the PSL and McIII sclerosis were more severe within the lame limbs, but mild gradations were also seen in control limbs. Intermediate gradings for a subset of lesions were commonly seen in the non-lame contralateral to lame limbs. Return to work in the lame group is not statistically different for any measured observation(s), and 19/33 of the lame horses returned to work at similar or higher levels.Conclusion and clinical importance: Fifty-eight percent in this group of warmblood horses returned to work within a variable time frame. The majority (81%) of lame limbs showed bone and soft tissue abnormalities, but no enlargement of the PSL was noted in lame horses, and no correlation was seen between the severity or type of lesions and the ability to return to work. The presence of STIR hyperintensity within the proximal McIII or dorsal collagenous part of the PSL and hyperintensity within the dorsal collagenous part of the PSL on T1W GRE and T2*W GRE images, as well as significant palmar cortical McIII resorption are considered clinically relevant lesions. Contralateral limbs may not truly represent the normal condition, showing nonclinical variations and adaptive remodeling.

scholarly journals Platelet-rich fibrin for hard- and soft-tissue healing in mandibular third molar extraction socket

2020 ◽  
Vol 10 (1) ◽  
pp. 102
Author(s):  
Mohammad Faisal ◽  
Deborah Sybil ◽  
Madhuri Sawai ◽  
Sanjay Singh ◽  
Vanshika Jain
Keyword(s):  
Soft Tissue ◽  
Third Molar ◽  
Soft Tissue Healing ◽  
Extraction Socket ◽  
Platelet Rich Fibrin ◽  
Third Molar Extraction ◽  
Tissue Healing ◽  
Mandibular Third Molar ◽  
Molar Extraction

scholarly journals Expression of angiogenic markers in jawbones and femur in a rat model treated with zoledronic acid

2022 ◽  
Vol 15 (1) ◽  
Author(s):  
Jing Wen Li ◽  
Jing Yi Wang ◽  
Ru Qing Yu ◽  
Lei Huo ◽  
Li Wu Zheng
Keyword(s):  
Gene Expression ◽  
Zoledronic Acid ◽  
Soft Tissue ◽  
Rat Model ◽  
Pcr Analysis ◽  
Control Group ◽  
Tissue Healing ◽  
Significant Difference ◽  
And Control ◽  
Group 1

Abstract Objectives This study aimed to investigate the gene expression of angiogenic marker in surgically treated jawbones and femur on a rat model administrated with zoledronic acid. Results No soft tissue fenestration or bone exposure was found in femur. Delayed soft tissue healing was found in both ZA group (3 in mandible, 4 in maxilla) and control group (1 in mandible, 2 in maxilla), while exposed bone was found only in the ZA group (1 in maxilla, 2 in mandible). RT-PCR analysis demonstrated no significant difference in gene expression of angiogenetic markers between ZA-treated and control groups in femur and mandible. In the maxilla, the expression of VEGFA and VEGFR-2 in medium-term ZA group was significantly down-regulated compared with that in the control. The ZA treatment does not change significantly the expression of the angiogenic factors in femur and mandible, but significantly downregulates the expression in maxilla in this rat model. The angiogenesis inhibition may contribute to the development of MRONJ but does not play a key role.

scholarly journals Does Platelet-Rich Fibrin Decrease Dimensional Changes and Improve Postoperative Comfort in Post-Extraction Sockets? An Overview of Systematic Reviews

2020 ◽  
Vol 10 (17) ◽  
pp. 5750 ◽  
Author(s):  
Vittorio Moraschini ◽  
Carlos Fernando de Almeida Barros Mourão ◽  
Rafael Coutinho de Mello Machado ◽  
Jhonathan Raphaell Barros Nascimento ◽  
Kayvon Javid ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bone Regeneration ◽  
Systematic Reviews ◽  
Selection Process ◽  
Soft Tissue Healing ◽  
Socket Preservation ◽  
Platelet Rich Fibrin ◽  
Dimensional Changes ◽  
Tissue Healing ◽  
The Impact

This overview aimed to evaluate the methods, quality, and outcomes of systematic reviews (SRs) conducted to investigate the effects of platelet-rich fibrin (PRF) in dental sockets on promoting bone regeneration and soft tissue healing and diminishing the incidence of pain, swelling, trismus, and alveolar osteitis after tooth extraction. An electronic search without date or language restriction was done in PubMed/MEDLINE, Cochrane, and Web of Science until March 2020. Eligibility criteria included SRs that assessed the effect of PRF for human alveolar socket preservation. The quality assessment of the included studies was performed using AMSTAR 2 guidelines. The protocol of this overview was recorded in PROSPERO under the number CRD42018089617. The search and selection process yielded 13 studies published between 2011 and 2018. The analysis of the studies showed inconclusive data for the effect of the PRF and the dimensional changes. There is no definitive evidence for the impact of using PRF alone on bone regeneration in post-extraction sockets. The use of PRF improves soft tissue healing and reduces pain, bleeding, and osteitis in post-extraction sockets.

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